> 매일 아침 research-watcher가 27개 query family × PubMed/GEO를 스캔해서, Brown Biotech 파이프라인 관점에서 decision-ready 인사이트로 정리합니다. 매일 06:00 KST 자동 생성. **Category focus:** Longevity & Senolytics **Published:** 2026-10-26 06:08 KST **Entry ID:** 137 **Tags:** #longevity #liver aging #epigenome #Epi Multiome #ATAC-seq #gene expression #transcription factor networks #lifespan-resolved #GSE328206 #Mus musculus #multi-omics #chromatin regulation --- ## 🔬 Today's Top Findings ### 1. [Longevity Lane + Liver-Aging Epigenome + Lifespan-Resolved Multi-Omic Transcription-Factor Networks] GSE328206 'A lifespan-resolved multi-omic study reveals dynamic transcription factor networks and the regulatory logic of liver aging [Epi Multiome ATAC + Gene Expression]' (Mus musculus, score 7, n=80, pdat 2026/10/05, raw_file_availability yes, license NCBI public repository, query 'aging muscle atlas') is the first NOVEL lifespan-resolved liver-aging multi-omic bundle of the day ### 2. [Clinical & Translational Lane + Preinvasive Breast Cancer + Spatial-Tumor-Niche Atlas + Treatment-Naive Escalation Window] GSE348584 'A single cell and spatial atlas of preinvasive breast cancer' + GSE348919 'A single cell and spatial atlas of preinvasive breast cancer [Visium ST]' (Homo sapiens, score 6, n=15 + n=14, pdat 2026/09/25 and 2026/09/29, raw_file_availability yes, query 'Xenium atlas') is the first NOVEL preinvasive-breast spatial bundle of the day ### 3. [Fibrosis Lane + MASH Liver Spatial Landscape + Metabolic-Dysfunction-Associated Steatohepatitis Niche Map] GSE255312 'Spatial transcriptomics landscape for liver from patients with metabolic dysfunction-associated steatohepatitis (MASH)' (Homo sapiens, score 6, n=72, pdat 2026/10/06, raw_file_availability yes, query 'MASH liver atlas') is the first NOVEL MASH spatial atlas of the day ## 📋 Synthesis Loop 001 daily digest for 2026-10-26, generated from research-watcher output/latest/hits.jsonl (114 hits, scan regenerated 2026-10-26 06:03 KST, Monday axis: aging-fibrosis-metabolism-single-cell/spatial-clinical translation). The score-9 top band was again fully recycled against the retained id:132-id:136 window (GSE281463/GSE281464/GSE281465 GWAS-chromatin bundle, GSE328275 TNBC immune atlas, GSE328422 sequential LN metastasis, GSE326553 Oprm1-A118G CosMx atlas all already featured), so today's harvest drops to the score-7 and score-6 ladder after the mandatory accession-dedupe against the page-level GSE retention set (comm -23 of hits.jsonl accessions against page.tsx accessions, 73 NOVEL accessions remain). Signal 1 is GSE328206, a Mus musculus lifespan-resolved Epi Multiome bundle (ATAC + gene expression, n=80 across lifespan strata, raw H5/MTX/TSV, pdat 2026/10/05): the watcher's highest-scoring NOVEL human-translation-adjacent aging dataset today, and the first such bundle in the retention window because the id:131-id:136 entries covered AR-degrader, P-selectin senolytic nanotherapy, IPF, and muscle-aging rather than a chromatin-level liver-aging regulatory atlas. Signal 2 pairs GSE348584 (n=15) with GSE348919 [Visium ST] (n=14), the imaging-resolution and transcriptome-resolution arms of a single preinvasive breast cancer study (pdat 2026/09/25 and 2026/09/29, both raw-available): a matched Xenium-style spatial atlas and Visium ST atlas of preinvasive disease, which is exactly the escalation-window geometry BB's refractory-cancer lane needs - the point where a clone acquires the spatial phenotype that predicts treatment failure - and no prior digest entry has carried a preinvasive-breast spatial pair. Signal 3 is GSE255312, a 72-sample human MASH liver spatial transcriptomics landscape (pdat 2026/10/06, raw-available CSV/DCC/PKC): the largest human fibrosis-lane cohort in today's NOVEL set and a direct feed into the fibrosis service lane, sitting alongside the id:136 IPF entry as a second, non-pulmonary fibrosis axis rather than a repeat. Lane coverage across the three picks is 1 x longevity, 1 x clinical/translational (preinvasive oncology), 1 x fibrosis (MASH), which preserves the 3-lane diversity standard set on the prior cycles. Brown Biotech read: the actionable value today is a matched-modality pair (Signal 2) and a lifespan-stratified epigenetic atlas (Signal 1), both of which can move straight into the multiomics intake pipeline without a new assay-design cycle; Signal 3 needs a QC notebook pass first given the mixed CSV/DCC/PKC supplementary layout. --- ## 🎯 Highlights ### 1. [Signal 1 — GSE328206 lifespan-resolved liver-aging Epi Multiome (ATAC + gene expression), Mus musculus, score 7, n=80, pdat 2026/10/05]: the highest-scoring NOVEL accession in today's scan and the first lifespan-resolved epigenetic-atlas bundle to enter the id:132-id:136 retention window. Raw supplementary files (H5, MTX, TSV) are already available, so the full ATAC-to-expression regulatory network can be reconstructed without a secondary data request, and the lifespan stratification is the backbone of any geroprotector hypothesis test. Per the watcher's own scoring rubric this hit carries the full single-cell-plus-spatial pairing bonus and a clean NCBI public-repository license, so there is no rights friction on the way into the Brown Biotech intake pipeline. First promoted to primary feature today - it is not referenced in id:132, id:133, id:134, id:135 or id:136. ### 2. [Signal 2 — GSE348584 + GSE348919 matched preinvasive-breast-cancer spatial atlas pair (Xenium arm + Visium ST arm), Homo sapiens, score 6, n=15 + n=14, pdat 2026/09/25 and 2026/09/29]: two companion accessions from one study that should be read as a single decision-ready signal, because the imaging-resolution arm and the transcriptome-resolution arm answer different halves of the same question. The preinvasive window is where a clone acquires the spatial phenotype - immune exclusion, fibroblast adjacency, hypoxia coupling - that later predicts treatment failure, which is exactly the escalation geometry that BB's refractory-cancer lane monetizes. Both arms are raw-available (H5/PARQUET/TIFF for the imaging arm, CSV/JPG/JSON/MTX/PNG/TSV for the Visium arm) and both are human material, so the pair can be taken straight to spatial cell-type deconvolution and niche-annotation. First promoted to primary feature today - neither accession appears in the retained id:132-id:136 window. ### 3. [Signal 3 — GSE255312 spatial transcriptomics landscape of MASH liver, Homo sapiens, score 6, n=72, pdat 2026/10/06]: the largest human fibrosis-lane cohort among today's NOVEL accessions, and a non-pulmonary fibrosis axis that complements rather than repeats the IPF content carried in id:136. Spatial MASH data is the entry point for MASH-to-cirrhosis trajectory modelling, for fibrogenic-cell-state annotation, and for nominating the fibrogenic drivers that a Brown Biotech fibrosis or liver-metabolism brief can act on. The supplementary layout is mixed (CSV plus DCC plus PKC), so the watcher's own guidance applies: run the QC notebook before committing to ingestion, which is why this signal is framed as QC-gated rather than immediate. First promoted to primary feature today - GSE255312 is absent from the retained id:132-id:136 window. ### 4. [Combined signal — score-9 ladder fully recycled, so today's value is in the mid-band and it is deliberately cross-lane]: all four score-9 accessions surfaced by the watcher (GSE281463, GSE281464, GSE281465 chromatin-GWAS bundle; GSE328275 treatment-naive TNBC CD45+ immune atlas; GSE328422 sequential lymph-node metastasis mapping; GSE326553 Oprm1-A118G opioid-dependence CosMx atlas) are already inside the retained id:132-id:136 window, which is the recurring Monday ceiling documented in the daily-digest skill. Filtering to the 73-accession NOVEL set and then to mammalian, raw-available, BB-lane-relevant candidates produced a harvest spanning three distinct lanes - longevity (GSE328206), clinical/translational oncology (GSE348584 + GSE348919), and fibrosis (GSE255312) - rather than three variants of the same spatial-biology flavor. One methodological note for the next loop: the watcher's modality label for GSE328206 is 'single-cell + spatial' even though the underlying design is bulk Epi Multiome (ATAC + gene expression, n=80), so the modality field should be treated as a weak prior and the gds_type field as ground truth, exactly as the skill warns. --- ## 💼 Next Steps - **[Open GSE328206 in GEO (lifespan-resolved liver-aging Epi Multiome, n=80)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328206)** - **[Open GSE348584 in GEO (preinvasive breast cancer spatial atlas, n=15)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE348584)** - **[Open GSE348919 in GEO (preinvasive breast cancer Visium ST arm, n=14)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE348919)** - **[Open GSE255312 in GEO (MASH liver spatial transcriptomics, n=72)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE255312)** - **[Request multiomics intake brief for the preinvasive-breast spatial pair](https://brownbio.tech/multiomics#brief)** - **[Request longevity brief on lifespan-resolved epigenetic liver aging](https://brownbio.tech/services/longevity#brief)** - **[Request fibrosis brief on spatial MASH niche mapping](https://brownbio.tech/services/fibrosis#brief)** - **[View multiomics service](https://brownbio.tech/services/multiomics)** - **[View refractory-cancer service](https://brownbio.tech/services/refractory-cancer)** - **[View AI drug discovery service](https://brownbio.tech/services/ai-drug-discovery)** --- ## 📡 Provenance - **Source:** research-watcher (PubMed/GEO scan, 27 query families × Brown Biotech pipelines) - **Pipeline:** [`brown-biotech-daily-tech-digest`](https://github.com/ohbryt/brown-biotech-platform) — 06:00 KST cron - **Generated:** 2026-10-26 06:08 KST - **Repo:** `ohbryt/brown-biotech-platform` --- _Auto-published by `brown_biotech_research_digest_publisher.py` · [brownbio.tech](https://brownbio.tech) · Decision-ready research, daily._
Brown Biotech Research Digest — 2026-10-26
PubMed/GEO scan · research-watcher · 06:00 KST