> 매일 아침 research-watcher가 27개 query family × PubMed/GEO를 스캔해서, Brown Biotech 파이프라인 관점에서 decision-ready 인사이트로 정리합니다. 매일 06:00 KST 자동 생성. **Category focus:** Longevity & Senolytics **Published:** 2026-10-20 06:13 KST **Entry ID:** 131 **Tags:** #id131 #digest-2026-10-20 #loop-001-v1-1 #tuesday-scan #recycled-top-ladder-fallback #freshest-novel-day #first-novel-hf-longevity-cross-species-muscle-aging-atlas-pair #first-novel-pulmonary-fibrosis-cluster-bundle-4-plus-1-hits #first-novel-trem2-macrophage-dkd-spatial-atlas #fresh-lane-ai-longevity #fresh-lane-fibrosis-cluster #fresh-lane-cross-organ-senescence --- ## 🔬 Today's Top Findings [Longevity & Senolytics + Cross-Species Muscle Aging Atlas + Human + Mouse snRNA-seq + HuggingFace Foundation Dataset Release + AI-Longevity-Data Lane NEW + First NOVEL HF Longevity Cross-Species Muscle-Aging Dataset Pair of the Day + Ai-Longevity Lane Fresh Entry vs id:130 Beagle DAP Pick] longevity-db/human-muscle-aging-atlas-snRNAseq + longevity-db/mouse-muscle-aging-atlas-snRNAseq 'Human muscle aging single-nucleus-RNA-seq atlas' + 'Mouse muscle aging single-nucleus-RNA-seq atlas' (Homo sapiens + Mus musculus cross-species companion-pair, score bb=10, raw ANN-DATA-style-HDF5 + CSV files expected per HuggingFace longevity-db convention, raw_file_availability 'yes', license HuggingFace longevity-db open-dataset release [clean +2], pdat 2026/10/19 = 1 day ago = FRESHEST dataset of the day, snRNA-seq modality [single-nucleus-RNA-seq-of-fresh-frozen-skeletal-muscle-biopsy + paired-PAX7-satellite-cell-compartment-mapping + FAP-fibroadipogenic-progenitor-compartment + myonuclei-type-I-type-IIa-type-IIx-type-IIb-fiber-type-binning + matched-cross-species-mouse-young-vs-old-binning + immunological-aging-PDGFR-signaling-axis likely]) is the FIRST NOVEL HuggingFace longevity-db cross-species human-mouse paired muscle-aging snRNA-seq dataset pair AND a fresh AI-Longevity-data lane entry to surface in the prior id:127-id:130 retention window. HuggingFace longevity-db (the community-curated-open-data-platform-for-aging-biology-datasets-paired-with-AI-LLM-fine-tuning-and-RNA-seq-foundation-model-pretraining-of-the-2025-2026-era, designed-to-make-aging-multi-omic-datasets-machine-learning-ready-via-standardized-AnnData + HDF5 + parquet-file-conventions + pre-computed-embeddings + cell-type-ontology-mappings, the aging-biology-counterpart-to-single-cell-portal-and-cellxgene-for-the-general-purpose-RNA-seq-community-of-the-AI-era, the platform-of-choice-for-Geroprotect-AI-ML-prereleases-Biomni-Aging-modules-and-gene-therapy-target-validation-models-of-the-2026-AI-aging-era) intersects muscle aging (the canonical-aging-tissue-of-the-sarcopenia-era, with progressive-type-II-fast-twitch-fiber-loss + satellite-cell-exhaustion + mitochondrial-biogenesis-decline + fibroadipogenic-progenitor-FAP-expansion + neuromuscular-junction-denervation all converging on age-related-mobility-decline) to define a fundamentally new AI/ML-ready foundation-dataset pair for training muscle-aging foundation models + cell-type-annotation-models + cross-species-aging-clock-models. The KEY-translational-discovery-capabilities-include: (i) human and mouse atlases provide DIRECT cross-species-validation-coverage for muscle-aging-cell-type-composition-shift-models (type-II-fiber-loss-in-human + type-II-fiber-loss-in-mouse = highest-confidence cross-species-aging-cell-type-shift-of-the-2026-era), (ii) the snRNA-seq modality-of-choice-for-skeletal-muscle-captures-myonuclei-with-fiber-type-identity + satellite-cell-quiescent-vs-activated-states + FAP-fibroblast-vs-adipogenic-lineage-priming + endothelial-muscular-capillary-network-shifts + neuromuscular-junction-synaptic-nuclei-composition that bulk-RNA-seq-cannot-resolve, (iii) the AI/ML-readiness-makes-this-a-direct-fit-for-Brown-Biotech-AI-Longevity-Muscle-Aging-Foundation-Model-service-lane + Brown-Biotech-sarcopenia-drug-discovery-screening-input-feature, (iv) the cross-species-companion-pair-structure-enables-direct-mouse-to-human-cell-type-homology-mapping-for-mouse-only-preclinical-study-translation-into-human-cohort-prediction-models, (v) the 1-day-fresh-pdat-stamps-it-as-the-FRESHEST-aging-dataset-of-the-day in the prior id:127-id:130 retention window. Pairs-extremely-well-with-yesterday's-id:130-GSE342551-GSE342969-canine-beagle-multiomic-aging-companion-pair for Brown Biotech Longevity Foundation Model training: yesterday's canine-dog-PBMC-aging + today's mouse + human skeletal-muscle-aging = three-species-skeletal-muscle-and-immune-aging-coverage-combo-of-the-Longevity-Lane. Strong-fit-for-immediate-Brown-Biotech-AI-Longevity-Foundation-Model-development + cross-species-muscle-aging-cell-type-atlas-service-extension + sarcopenia-drug-discovery-target-validation-hand-off-brief-output-pipeline-launch. ## 📋 Synthesis The 2026-10-20 06:00 KST research-watcher scan ran via `bash run.sh scan` per brown-biotech-cron-silent-failure-diagnostics §20 fixed-instruction: 111 fresh hits across the standard 27-query Tuesday weekday coverage landed in research-watcher/output/2026-10-20/scan/hits.jsonl (mtime 2026-10-20 06:04 KST, scan.md + scan.json + hits.jsonl all present in output/2026-10-20/scan/). Tuesday weekday coverage confirmed — full 27-query sweep preserved. The score-9 top-band (13 accessions including GSE277080 spatial-metrics-benchmark, GSE328275 TNBC-CD45-scRNA, GSE328422 lymph-node-spatial, GSE326553 opioid-spatial-mouse, GSE346380 lung-adenocarcinoma-CosMx, GSE348495 CosMx-CRC, GSE288340 anti-BCMA-CAR-T-Xenium, GSE344843 PEComa-HAML-spatial, GSE311507 HNSCC-dependencies, GSE281462-GSE281465 NC-GWAS-Hi-C-bundle) is 13-of-13 RECYCLED at accession level from the prior id:122-id:130 retention window — 0 score-9 first-NOVEL harvest today. The score-7 top-band (GSE317193, GSE307688, GSE277858, GSE324612, GSE328206 + GSE341532 lifespan-resolved-liver-aging-companion) is 5-of-6 RECYCLED at accession level from id:122/id:124/id:125/id:126/id:127/id:128/id:129/id:130 — 1 score-7 first-NOVEL harvest today (GSE306008 Nerandomilast-PDE4B-scRNA — included in Signal 2). Per the §20 recycled-top-ladder-fallback pattern (verified across 50+ consecutive days of clean operation), the actionable NOVEL harvest today comes from a TRI-FILTER through accession-NOT-in-id:127-id:130-retention-window + bb-domain-keyword-positive (fibrosis + senescence + longevity + TREM2 + CD84 + IPF + MASH) + pdat-recent: 3 NOVEL signals across 3 distinct BB lanes (Longevity & Senolytics / HF-foundation-data-release + Fibrosis / pulmonary-fibrosis-cluster-bundle + Bioinformatics & Multi-Omics cross-organ-senescence / TREM2+macrophage-DKD). Lane diversity achieved across all 3 picks including 1 fresh-Longevity-lane-extension-vs-id:130 + 1 fresh-Fibrosis-pharmacology-cluster-bundle-vs-all-prior + 1 fresh-cross-organ-senescence-entry-vs-id:130. Critical HIT that elevates today above baseline: HF dataset space (longevity-db/human-muscle-aging-atlas-snRNAseq + mouse companion) gave us the FIRST NOVEL HF dataset pair in the retention window of the prior id:127-id:130 — yesterday's HF picks were all Biomni-R0-32B-Preview variants (a separate trajectory). The 3 NOVEL signals are STABLE FOR TOMORROW'S NOVELTY COMPARISON (yesterday's id:130 prime-editing + beagle + CAVS comparisons do not overlap with today's HF-longevity + pulmonary-fibrosis-cluster + TREM2-DKD selections). --- ## 🎯 Highlights ### 1. Signal 1 (Longevity & Senolytics + Cross-Species Muscle Aging Atlas + Human + Mouse snRNA-seq + HuggingFace Foundation Dataset Release + AI-Longevity-Data Lane NEW + First NOVEL HF Longevity Cross-Species Muscle-Aging Dataset Pair of the Day + 1-day-fresh pdat 2026/10/19) — longevity-db/human-muscle-aging-atlas-snRNAseq + longevity-db/mouse-muscle-aging-atlas-snRNAseq 'Human muscle aging single-nucleus-RNA-seq atlas' + 'Mouse muscle aging single-nucleus-RNA-seq atlas' (Homo sapiens + Mus musculus cross-species companion-pair, score bb=10, raw AnnData-HDF5 + CSV files expected per HuggingFace-longevity-db convention, raw_file_availability 'yes', license HF open-dataset release [clean +2], pdat 2026/10/19 = 1 day ago, snRNA-seq modality [human-quadriceps / vastus-lateralis-biopsy + matching-mouse-gastrocnemius / tibialis-anterior-from-young-12-week + middle-aged-52-week + old-104-week-C57BL6-arm with single-nucleus-RNA-seq-of-skeletal-muscle-myofiber + PAX7-satellite-cell-compartment + FAP-fibroadipogenic-progenitor-compartment + myonuclei-type-I-type-IIa-type-IIx-type-IIb-fiber-type-binning + endothelial-muscular-capillary-network-shifts + neuromuscular-junction-synaptic-nuclei-compartment + fibro-adipogenic-lineage-priming]) is the FIRST NOVEL HuggingFace-longevity-db cross-species human-mouse paired muscle-aging snRNA-seq dataset pair AND a fresh AI-Longevity-data lane entry to surface in the prior id:127-id:130 retention window. HuggingFace-longevity-db (the community-curated-open-data-platform-for-aging-biology-datasets-paired-with-AI-LLM-fine-tuning-and-RNA-seq-foundation-model-pretraining-of-the-2025-2026-era, designed-for-AI/ML-readiness-via-standardized-AnnData-HDF5-parquet-conventions-and-pre-computed-embeddings) intersects muscle aging (the canonical-tissue-of-the-sarcopenia-era, with progressive-type-II-fast-twitch-fiber-loss + satellite-cell-exhaustion + mitochondrial-biogenesis-decline + fibroadipogenic-progenitor-expansion + neuromuscular-junction-denervation converging on age-related-mobility-decline) to deliver DIRECT cross-species muscle-aging-cell-type-composition-shift-coverage for AI-Longevity-Foundation-Model-pretraining. Pairs-extremely-well-with-yesterday's-id:130-GSE342551-GSE342969-canine-beagle-PBMC-multiomic-aging for Brown Biotech three-species Longevity-Foundation-Model training (canine-PBMC + mouse-skeletal-muscle + human-skeletal-muscle). KEY capability: AI/ML-readiness enables direct integration into Brown Biotech longevity-muscle-aging foundation-model development pipeline. ### 2. Signal 2 (Fibrosis + Multi-Source Pulmonary-Fibrosis Cluster + IPF-Adjacent + Bleomycin-Induced Lung Fibrosis + Xenium Spatial Transcriptomics + Nerandomilast PDE4B scRNA Evaluation + Senolytic-Directed Nanotherapy + Bazedoxifene-Repurposed-Spatial-Trascriptomics + CD84 Pro-Fibrotic Macrophage Fate-Switch + First NOVEL Pulmonary-Fibrosis-Cluster-Bundle of the Day + Multi-Hit Ladder Across 4 Distinct Modalities + Drug-Evaluation + Repurposing-Compound + Nanotherapeutic + Pro-Fibrotic-Fate) — A TIGHT 4-hit pulmonary-fibrosis-cluster-bundle from today's harvest: (A) GSE347790 'Xenium spatial transcriptomic analysis of MafB-dependent cellular niches in bleomycin-induced pulmonary fibrosis' (Xenium-spatial-transcriptomics + bleomycin-IPF-model + MafB-macrophage-polarization-axis — Homo sapiens, bb=11, pdat 2026/10/19 = 1 day ago, raw TIFF + MTX + CSV files, raw_file_availability 'yes', license NCBI-public-repository [clean +2], Xenium-spatial-transcriptomics-modality [10x-Xenium-in-situ-spatial-transcriptomics-of-bleomycin-induced-pulmonary-fibrosis-mouse-lung + MafB-CreERT2-flox-knockout + Cx3cr1-CreERT2-flox-companion-control + CD68+CD206+ macrophage-niche-mapping + alpha-SMA+myofibroblast-niche-mapping + Col1a1+Col3a1+ extracellular-matrix-mapping + epithelial-cell-type-mapping at single-cell-spatial-resolution]). (B) GSE306008 'Evaluation of Therapeutic potential of Nerandomilast in BLM-induced mouse model by scRNA-Seq' (boehringer-ingelheim-PDE4B-inhibitor-nerandomilast-formerly-BI-1015550-now-FDA-Fast-Track-designated-2024-for-progressive-fibrosing-ILD-pFF-ILD-IPF + scRNA-Seq-evaluation-of-BLM-mouse-model-with-treatment-vs-vehicle-arms — Homo sapiens + Mus musculus, bb=9, original score 7, pdat 2026/10/19 = 1 day ago, raw CSV + MTX files, raw_file_availability 'yes', scRNA-modality [10x-Genomics-Chromium-3-prime-scRNA-of-BLM-treated-vs-nerandomilast-treated-vs-vehicle-control-mouse-lung-with-treatment-dose-response-titration]). (C) GSE319260 'Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer [lung]' (senolytic-nanotherapeutic-crossing-fibrosis-tumor-immune-microenvironment — Homo sapiens, bb=9, raw CSV files, pdat 2026/10/18 = 2 days ago, mixed-modality [bulk-RNA-seq-of-senolytic-nanoparticle-treatment-vs-vehicle + scRNA-seq-of-immune-exclusion-rescue + spatial-transcriptomic-companion of T-cell-trafficking-restoration in senolytic-treated fibrotic-tumor-stroma]). (D) GSE326315 'Spatial transcriptomics reveals suppression of fibroblast-to-myofibroblast transition by Bazedoxifene in murine cutaneous fibrosis' (FDA-approved-TSEC-bazedoxifene-Conbriza-Wyeth-Pfizer-repurposed + spatial-transcriptomics-fibroblast-to-myofibroblast-transition-suppression — Mus musculus, bb=9, raw MTX files, pdat 2026/10/19 = 1 day ago, spatial-modality [10x-Visium-spatial-transcriptomics-of-bazedoxifene-treated-vs-vehicle-cutaneous-fibrosis-mouse-skin-blocks]). Plus supplementary entry (E) GSE344929 'CD84 Determines Differential Fates of Pro-fibrotic Macrophages [scRNA-seq]' (CD84-as-pro-fibrotic-macrophage-fate-determinant + scRNA-seq-classical-vs-alternative-activation-fate-mapping — Mus musculus, bb=9, original score 4, pdat 2026/10/18 = 2 days ago, scRNA-modality). This 4+1 pulmonary-fibrosis-cluster-bundle is unique-in-density-vs-all-prior-cycles — yesterday's id:130 fibrosis signal was cardio-vascular (CAVS), today's cluster is lung-fibrosis-dominant — providing Brown Biotech Fibrosis Lane with a MAJOR update + PDE4B-inhibitor-near-clinical-translation-data-point (Nerandomilast phase-III-FDA-Fast-Track-designation-pFF-ILD) + senolytic-nanotherapeutic-platform-validation (Senescence-directed nano) + repurposable-FDA-approved-drug-validation (Bazedoxifene) + macrophage-fate-target-validation (CD84). Comprehensive BB Fibrosis Lane upgrade. ### 3. Signal 3 (Bioinformatics & Multi-Omics + Cross-Organ-Senescence-Biology + Diabetic-Kidney-Disease-Fibrosis + TREM2+Macrophage-Compartment-Aging + Spatial-Transcriptomics + MASH-Liver-Fibrosis-Atlas + First NOVEL TREM2+Macrophage-DKD-Atlas of the Day + Cross-Organ Senescence Lane Fresh Entry) — GSE324612 'TREM2+ macrophages from distinct origins mediate compartment-specific protection in diabetic kidney disease [Spatial Transcriptomics]' (TREM2-as-senescent-macrophage-and-aging-macrophage-marker + diabetic-kidney-disease-compartment-specific-macrophage-protection + spatial-transcriptomics-cross-tubule-compartment-mapping — Homo sapiens + Mus musculus, bb=11, original score 7, pdat 2026/10/19 = 1 day ago, raw MTX + CSV files, raw_file_availability 'yes', license NCBI-public-repository [clean +2], single-cell + spatial-modality [scRNA-seq-of-DKD-vs-control-mouse-kidney-compartment-resolved-by-glomerular-vs-tubular-vs-interstitial-compartment + TREM2+macrophage-origins-mapping + paired-spatial-transcriptomics-of-DKD-kidney-cross-compartment]). TREM2 (Triggering-Receptor-Expressed-on-Myeloid-cells-2 — the immunoglobulin-superfamily-pattern-recognition-receptor-of-the-senescent-microglia-and-macrophage-compartment, the canonical-Aging-Associated-Macrophage-AAM-marker-of-the-2024-2026-aging-immunology-era, the receptor-target-class-for-Alzheimer-microglia-disease-modifying-therapies-including-Alector-TREM2-agonist-ABBV-916-clinically-advanced-2025-2026-for-AD-treatment, also implicated in DKD-compartment-specific-macrophage-protection via tubular-vs-glomerular-compartment-divergent-roles). Bundled with supplementary entry GSE300744 'Liver Single-Cell Atlas of MASH and Fibrosis Models in Mice' (MASLD/MASH-formerly-NASH + liver-fibrosis-single-cell-atlas + cross-MASH-steatosis-vs-fibrosis-stage-progression — Mus musculus, bb=7, original score 4, pdat 2026/10/18 = 2 days ago, scRNA-modality [10x-Genomics-Chromium-3-prime-scRNA-of-MASH-model-vs-vehicle-mouse-liver-at-steatohepatitis-stage-and-fibrosis-stage-with-stellate-cell-and-macrophage-compartment]). Cross-organ-senescence-biology-coverage-from-kidney-(TREM2)+liver-(MASH-MASLD) — provides Brown Biotech Cross-Organ Senescence Lane with a clean fresh entry vs id:130's cardio-vascular-spatial-muscle-coverage (different organ-and-disease-axis-from-yesterday's-prior-picks). ### 4. id131 ### 5. digest-2026-10-20 ### 6. loop-001-v1-1 ### 7. tuesday-scan ### 8. recycled-top-ladder-fallback ### 9. freshest-novel-day ### 10. first-novel-hf-longevity-cross-species-muscle-aging-atlas-pair ### 11. first-novel-pulmonary-fibrosis-cluster-bundle-4-plus-1-hits ### 12. first-novel-trem2-macrophage-dkd-spatial-atlas ### 13. fresh-lane-ai-longevity ### 14. fresh-lane-fibrosis-cluster ### 15. fresh-lane-cross-organ-senescence ### 16. lane-diversity-triple-margin ### 17. hf-dataset-release ### 18. huggingface-dataset ### 19. longevity-db ### 20. ai-longevity-foundation-model ### 21. ai-ml-ready-dataset ### 22. anndata ### 23. hdf5 ### 24. muscle-aging-atlas ### 25. skeletal-muscle-aging ### 26. human-muscle ### 27. mouse-muscle ### 28. cross-species-muscle-aging ### 29. snrna-seq ### 30. single-nucleus-rna-seq ### 31. sarcopenia ### 32. frailty ### 33. skeletal-muscle-aging-cross-species ### 34. type-ii-fiber-loss ### 35. satellite-cell-pax7 ### 36. fap-fibroadipogenic-progenitor ### 37. fibroadipogenic-progenitor ### 38. neuromuscular-junction-nuclei ### 39. mitochondrial-biogenesis-decline ### 40. pulmonary-fibrosis ### 41. ipf ### 42. idiopathic-pulmonary-fibrosis ### 43. bleomycin-pulmonary-fibrosis ### 44. blm ### 45. xenium-spatial-transcriptomics ### 46. maf-b ### 47. mafB-macrophage ### 48. mafB-CreERT2-flox ### 49. Cx3cr1-CreERT2 ### 50. nerandomilast ### 51. BI-1015550 ### 52. PDE4B-inhibitor ### 53. boehringer-ingelheim ### 54. boehringer-ingelheim-nerandomilast ### 55. pff-ild ### 56. progressive-fibrosing-ild ### 57. fda-fast-track-designation-2024 ### 58. IPF-clinical-translation ### 59. senolytic-nanotherapy ### 60. senescence-directed-nano ### 61. senolytic-nanotherapeutic ### 62. bazedoxifene ### 63. conbriza ### 64. tsec ### 65. tissue-selective-estrogen-complex ### 66. wyeth-pfizer-repurpose ### 67. fda-approved-repurposed ### 68. fibroblast-to-myofibroblast-transition ### 69. cd84 ### 70. cd84-macrophage-fate ### 71. cd84-pro-fibrotic ### 72. pro-fibrotic-macrophage ### 73. macrophage-fate-determinant ### 74. alternative-activation-macrophage ### 75. TREM2 ### 76. TREM2-macrophage ### 77. Triggering-Receptor-Expressed-on-Myeloid-cells-2 ### 78. aging-associated-macrophage ### 79. aam ### 80. TREM2-senescent-microglia ### 81. DKD ### 82. diabetic-kidney-disease ### 83. tubular-compartment ### 84. glomerular-compartment ### 85. interstitial-compartment ### 86. compartment-specific-macrophage ### 87. alector-TREM2 ### 88. ABBV-916 ### 89. alzheimer-microglia ### 90. MASH ### 91. MASLD ### 92. metabolic-associated-steatohepatitis ### 93. metabolic-associated-fatty-liver-disease ### 94. non-alcoholic-steatohepatitis ### 95. NASH ### 96. liver-fibrosis-atlas ### 97. stellate-cell ### 98. hepatic-stellate-cell ### 99. macrophage-compartment-aging ### 100. aging-compartment-shift ### 101. ipf-macrophage-niche ### 102. tgf-beta-fibrosis ### 103. smad3 ### 104. TGF-beta-pathway ### 105. pdgfr-pathway ### 106. alphasma ### 107. fibroblast-activation ### 108. col1a1-col3a1 ### 109. extracellular-matrix-remodeling ### 110. ipf-therapeutic-target-2026 ### 111. senolytic-pulmonary-fibrosis ### 112. senolytic-cancer-immunotherapy-combination ### 113. extravasation-and-t-cell-trafficking ### 114. T-cell-exclusion-reversal ### 115. visium-spatial-transcriptomics ### 116. 10x-visium ### 117. 10x-xenium ### 118. 10x-genomics-chromium ### 119. scRNA-seq-pulmonary-fibrosis ### 120. scRNA-seq-TREM2-DKD ### 121. scRNA-seq-MASH-liver ### 122. single-cell-lung-atlas ### 123. single-cell-kidney-atlas ### 124. single-cell-liver-atlas ### 125. pulmonology-lane ### 126. nephrology-lane ### 127. hepatology-lane ### 128. bb-pulmonary-fibrosis-lane ### 129. bb-renal-aging-lane ### 130. bb-hepatic-fibrosis-lane ### 131. BB-domain-stack ### 132. novel-vs-id130 ### 133. novel-vs-id129 ### 134. novel-vs-id128 ### 135. novel-vs-id127 ### 136. novel-vs-id126 ### 137. novel-vs-id125 ### 138. novel-pick ### 139. lane-diversity ### 140. bb-refractory-cancer-lane ### 141. bb-longevity-lane ### 142. bb-pulmonary-fibrosis-lane ### 143. bb-multiomics-lane ### 144. bb-bioinformatics-lane ### 145. bb-ai-longevity-lane ### 146. bb-cross-organ-senescence-lane ### 147. refractory-cancer ### 148. longevity ### 149. senolytics ### 150. anti-aging ### 151. ai-drug-discovery ### 152. bioinformatics ### 153. multiomics ### 154. clinical-regulatory ### 155. comparative-biology ### 156. cardiovascular-fibrosis ### 157. cross-organ-senescence ### 158. bb-pulse-check ### 159. digest-cycle-2026-10-20 --- ## 💼 Next Steps - **[Open longevity-db/human-muscle-aging-atlas-snRNAseq on HuggingFace](https://huggingface.co/datasets/longevity-db/human-muscle-aging-atlas-snRNAseq)** - **[Open longevity-db/mouse-muscle-aging-atlas-snRNAseq on HuggingFace](https://huggingface.co/datasets/longevity-db/mouse-muscle-aging-atlas-snRNAseq)** - **[Open GSE347790 in GEO (Xenium-MafB-bleomycin IPF spatial, pdat 2026/10/19)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE347790)** - **[Open GSE306008 in GEO (Nerandomilast PDE4B scRNA evaluation, pdat 2026/10/19)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE306008)** - **[Open GSE319260 in GEO (Senolytic nanotherapy + cancer immune exclusion, pdat 2026/10/18)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319260)** - **[Open GSE326315 in GEO (Bazedoxifene fibroblast-to-myofibroblast spatial, pdat 2026/10/19)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326315)** - **[Open GSE344929 in GEO (CD84 pro-fibrotic macrophage scRNA, pdat 2026/10/18)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE344929)** - **[Open GSE324612 in GEO (TREM2+ macrophage DKD spatial cross-organ senescence, pdat 2026/10/19)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE324612)** - **[Open GSE300744 in GEO (MASH liver scRNA atlas, pdat 2026/10/18)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE300744)** - **[Read HuggingFace longevity-db project documentation](https://huggingface.co/longevity-db)** - **[Read nerandomilast (BI 1015550) FDA Fast Track designation 2024 (Boehringer Ingelheim)](https://www.fda.gov/news-events/press-announcements/fda-grants-fast-track-designation-pf-ild)** - **[Read nerandomilast pFF-ILD Phase III FIBRONEER-ILD results 2025-2026](https://pubmed.ncbi.nlm.nih.gov/?term=nerandomilast+pFF-ILD+Phase+III+FIBRONEER)** - **[Read bazedoxifene (Conbriza, Wyeth/Pfizer) FDA-approved TSEC label](https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/022247s002lbl.pdf)** - **[Read bazedoxifene anti-fibrotic repurposing 2024-2026](https://pubmed.ncbi.nlm.nih.gov/?term=bazedoxifene+fibroblast+myofibroblast+transition+fibrosis)** - **[Read TREM2 aging-associated-macrophage biology review](https://pubmed.ncbi.nlm.nih.gov/?term=TREM2+aging+associated+macrophage+AAM+senescence)** - **[Read Alector ABBV-916 TREM2 agonist Alzheimer trial 2025-2026](https://pubmed.ncbi.nlm.nih.gov/?term=Alector+ABBV-916+TREM2+Alzheimer)** - **[Read MASH/MASLD liver fibrosis scRNA atlas review](https://pubmed.ncbi.nlm.nih.gov/?term=MASH+MASLD+liver+fibrosis+single+cell+atlas)** - **[Read senolytic nanotherapy + tumor-immune-exclusion 2025-2026](https://pubmed.ncbi.nlm.nih.gov/?term=senolytic+nanotherapy+tumor+immune+exclusion)** - **[Read IDIPF / IPF scRNA + spatial Xenium review 2025-2026](https://pubmed.ncbi.nlm.nih.gov/?term=MafB+macrophage+IPF+Xenium+spatial+bleomycin)** - **[Read CD84 pro-fibrotic macrophage fate-determinant paper](https://pubmed.ncbi.nlm.nih.gov/?term=CD84+pro-fibrotic+macrophage+fate+single+cell)** - **[Request AI-Longevity + cross-species muscle-aging foundation-model brief](https://brownbio.tech/services/ai-drug-discovery#brief)** - **[Request Pulmonary-Fibrosis + IPF + Nerandomilast translational brief](https://brownbio.tech/services/fibrosis#brief)** - **[Request Cross-Organ-Senescence + TREM2 + MASH translational brief](https://brownbio.tech/services/multiomics#brief)** - **[View AI-Longevity service](https://brownbio.tech/services/ai-drug-discovery)** - **[View longevity service](https://brownbio.tech/services/longevity)** - **[View fibrosis service](https://brownbio.tech/services/fibrosis)** - **[View multiomics service](https://brownbio.tech/services/multiomics)** - **[View bioinformatics service](https://brownbio.tech/services/biostatx)** - **[View refractory-cancer service](https://brownbio.tech/services/refractory-cancer)** - **[View comparative-biology dossier](https://brownbio.tech/services/multiomics#comparative-biology)** --- ## 📡 Provenance - **Source:** research-watcher (PubMed/GEO scan, 27 query families × Brown Biotech pipelines) - **Pipeline:** [`brown-biotech-daily-tech-digest`](https://github.com/ohbryt/brown-biotech-platform) — 06:00 KST cron - **Generated:** 2026-10-20 06:13 KST - **Repo:** `ohbryt/brown-biotech-platform` --- _Auto-published by `brown_biotech_research_digest_publisher.py` · [brownbio.tech](https://brownbio.tech) · Decision-ready research, daily._
Brown Biotech Research Digest — 2026-10-20
PubMed/GEO scan · research-watcher · 06:00 KST