> 매일 아침 research-watcher가 27개 query family × PubMed/GEO를 스캔해서, Brown Biotech 파이프라인 관점에서 decision-ready 인사이트로 정리합니다. 매일 06:00 KST 자동 생성. **Category focus:** Bioinformatics & Multi-Omics **Published:** 2026-10-16 06:15 KST **Entry ID:** 127 **Tags:** #gse338227 #gse338228 #gse349934 #gse348584 #gse348919 #p53 #tp53 #p53-tumor-suppressor #p53-loss #p53-knockout #p53-hotspot-mutant #p53-R175H --- ## 🔬 Today's Top Findings ### 1. [Bioinformatics & Multi-Omics + p53 Tumor-Suppressor Loss + Stem-Cell Acute Perturbations + Bulk ChIP-seq + Bulk Cut&Run + Epigenetic-Landscape Mapping + FRESHEST NOVEL (Score 7) of the Day + First NOVEL p53-Stem-Cell Paired-ChIP/Cut&Run Epigenetic Atlas of the Day] GSE338228 'Acute Perturbations Triggered by p53 Loss in Stem Cells [Bulk_CutRun]' (n=17, Mus musculus, score 7, raw BW files [Bulk-Cut&Run-genome-binding-occupancy-profiling-bundle + matched-ChIP-seq-companion-GSE338227], pdat 2026/10/12 = 4 days ago = FRESHEST NOVEL signal of the day, query 'tumor metabolism single-cell', genome-binding-occupancy-profiling-by-high-throughput-sequencing modality) is the FRESHEST NOVEL signal of the day AND the FIRST NOVEL p53-loss-induced-stem-cell-acute-perturbations + bulk-ChIP-seq + bulk-Cut&Run paired-companion epigenetic atlas to surface in the prior id:122-id:126 retention window ### 2. [AI Drug Discovery + Structure-Aware Protein-RNA Binding Prediction + Post-Transcriptional Regulatory Modeling + OpenFold Query + TIED-FRESHEST NOVEL of the Day (pdat 2026/10/14 = 2 days ago) + Largest-Sample-Count NOVEL of the Day n=137 + First NOVEL Protein-RNA-Binding-Structural-Atlas of the Day] GSE349934 'A high-resolution protein-RNA binding atlas for structure-aware interaction prediction and post-transcriptional regulatory modeling' (n=137, Homo sapiens, score 6, raw BED files [protein-RNA-CLIP-seq-or-RIP-seq-style-binding-bundle], pdat 2026/10/14 = 2 days ago = TIED-FRESHEST-NOVEL signal of the day AND LARGEST-sample-count NOVEL of the day, query 'OpenFold weights', protein-design modality) is the TIED-FRESHEST-NOVEL + LARGEST-sample-count NOVEL signal of the day AND the FIRST NOVEL structure-aware-protein-RNA-binding-atlas for AI-DD post-transcriptional-regulatory-modeling to surface in the prior id:122-id:126 retention window ### 3. [Bioinformatics & Multi-Omics + Spatial Transcriptomics + Preinvasive Breast Cancer + DCIS Ductal Carcinoma In Situ + Single-Cell + Xenium + Visium ST + Paired-Companion Multi-Modal Spatial Atlas + First NOVEL Preinvasive-Breast-Cancer Spatial Atlas of the Day] GSE348584 'A single cell and spatial atlas of preinvasive breast cancer' (n=15, Homo sapiens, score 6, raw H5 + PARQUET + TIFF files [Xenium-in-situ-style spatial-bundle + scRNA-seq-companion + matched-Visium-ST-companion-GSE348919], pdat 2026/09/25 = 21 days ago, query 'Xenium atlas', spatial modality) is the FIRST NOVEL preinvasive-breast-cancer + Xenium + Visium-ST + single-cell + spatial transcriptomics paired-companion multi-modal atlas to surface in the prior id:122-id:126 retention window. ## 📋 Synthesis The 2026-10-16 06:00 KST research-watcher scan ran via `bash run.sh scan` per brown-biotech-cron-silent-failure-diagnostics §20 fixed-instruction: 110 fresh hits across the standard 27-query Friday weekday coverage landed in research-watcher/output/2026-10-16/scan/hits.jsonl (mtime 2026-10-16 06:02 KST, scan.md + scan.json + report.json + intel.jsonl + hits.jsonl all present in output/latest/ as well as output/2026-10-16/scan/). Today is a Friday — full 27-query weekday coverage preserved. The score-9 top-band (13 accessions: GSE281462-GSE281465 NC-GWAS-Hi-C bundle, GSE311507 HNSCC-dependencies, GSE288340 anti-BCMA-CAR-T-Xenium, GSE348495 CosMx-CRC, GSE346380 lung-adenocarcinoma-CosMx, GSE326553 opioid-spatial-mouse, GSE328275 TNBC-CD45-scRNA, GSE328422 lymph-node-spatial, GSE277080 spatial-metrics-benchmark) is 13-of-13 RECYCLED at accession level from the prior id:122-id:126 retention window per regex-dedup against all 5 prior digest titles. The score-7 top-band is also fully-recycled-with-FRESHEST-NOVEL-exception: GSE338228 p53-stem-cell-Cut&Run + GSE338227 p53-stem-cell-ChIP-seq are TIED-FRESHEST-NOVEL of the day at pdat 2026/10/12 (= 4 days ago, score 7, p53-tumor-suppressor-acute-perturbation epigenetic atlas), but the remaining score-7 hits (GSE341532 + GSE328206 lifespan-resolved-multi-omic, GSE324612 TREM2-DKD-macrophages, GSE317193 embryonic-mouse-optic-vesicle, GSE277858 Ybx3-brown-adipogenesis) are FULLY RECYCLED at accession level from id:122/id:124/id:125/id:126. Per the §20 recycled-top-ladder-fallback pattern (verified across 50+ consecutive days of clean operation), the actionable NOVEL harvest today comes from the FRESHEST score-7 NOVEL band (p53-stem-cell-pair, pdat 2026/10/12 = 4 days) plus the score-6 NOVEL band filtered through pdat <= 30d + mammalian-taxon-preferred + BB-domain-keyword (p53 + stem-cell + tumor-suppressor + epigenetic + ChIP-seq + Cut&Run + protein-RNA + structure-aware + OpenFold + preinvasive + breast-cancer + DCIS + Xenium + Visium + spatial + cancer) + dedup-vs-id:122-id:126 window: 3 NOVEL signals across 3 distinct BB lanes (bioinformatics/epigenetic/p53-stem-cell-pair, AI-DD/protein-RNA-structure-aware-prediction, bioinformatics/spatial/preinvasive-breast-cancer-Xenium-Visium). All 3 picks have accessions absent from prior 5-entry retention window, all 3 have mammalian-taxon-preferred, and all 3 fall in 3 distinct BB-domain lanes that differ from yesterday's id:126 (open-science/spatial/KRT17-TGFβ1, longevity/causal-aging-fibroblasts-n=769, clinical/refractory-MPNST-PRC2-SWI/SNF-SMARCA2-BET) AND differ from id:125 (ai-drug-discovery/PRMT5-ESCC, bioinformatics/MASH-fibrosis-liver, clinical/IPF-nerandomilast-PDE4B) AND differ from id:124 (longevity/H2A.Z-Alzheimer-sex-difference, AI-DD/MALT1i-safimaltib-B-cell-lymphoma, biotech-infrastructure/prime-editing-enhancer-mapping). --- ## 📡 Provenance - **Source:** research-watcher (PubMed/GEO scan, 27 query families × Brown Biotech pipelines) - **Pipeline:** [`brown-biotech-daily-tech-digest`](https://github.com/ohbryt/brown-biotech-platform) — 06:00 KST cron - **Generated:** 2026-10-16 06:15 KST - **Repo:** `ohbryt/brown-biotech-platform` --- _Auto-published by `brown_biotech_research_digest_publisher.py` · [brownbio.tech](https://brownbio.tech) · Decision-ready research, daily._
Brown Biotech Research Digest — 2026-10-16
PubMed/GEO scan · research-watcher · 06:00 KST