> 매일 아침 research-watcher가 27개 query family × PubMed/GEO를 스캔해서, Brown Biotech 파이프라인 관점에서 decision-ready 인사이트로 정리합니다. 매일 06:00 KST 자동 생성. **Category focus:** Longevity & Senolytics **Published:** 2026-10-12 06:11 KST **Entry ID:** 123 **Tags:** #gse279204 #gse313628 #gse349638 #telomere #telomere-biology #telomere-shortening #telomere-attrition #telomere-length #shelterin-complex #shelterin #TRF1 #TRF2 --- ## 🔬 Today's Top Findings ### 1. [Longevity & Anti-Aging + Telomere Shortening + Human Semi-Guided Organoid Aging Model + 2-Month vs 4-Month Cell-State Transition + First NOVEL Human-Telomere-Organoid-Aging scRNA-seq Atlas of the Day + Freshest Longevity NOVEL of the Day] Effects of telomere shortening on cell composition and cell state in 2- and 4-month human semi-guided organoids (GSE279204, score 6, n=4, Homo sapiens, pdat 2026/10/10 = 2 days ago = FRESHEST longevity NOVEL signal of the day, raw MTX + TSV files, single-cell modality, Expression profiling by high throughput sequencing, the FIRST NOVEL human semi-guided organoid + telomere-shortening + 2-month-vs-4-month aging-transition scRNA-seq atlas to surface in the prior id:118-id:122 retention window — a direct longevity + anti-aging + telomere-biology + organoid-aging + replicative-senescence input for the BB longevity + bioinformatics + AI-DD lane with explicit overlap to the telomere-biology / shelterin-complex-TRF1-TRF2-TIN2-TPP1-RAP1-POT1 / telomerase-TERT-TERC / telomere-position-effect-over-long-distance-TPE-OLD / telomere-DNA-damage-response-TDDR-ATM-ATR-Chk2 / cellular-replicative-senescence-Hayflick-limit / p16-INK4a-CDK4-6-pRB-E2F-senescence-axis / p21-CIP1-WAF1-CDK2-p21-cell-cycle-arrest / SASP-CXCL8-IL6-IL1B-TNF / organoid-aging-model / iPSC-derived-organoid-aging / intestinal-organoid-crypt-niche / Lgr5-stem-cell-aging / Olfm4-Bmi1-asymmetric-division / mTOR-NAD-depletion / rapamycin-metformin-NR-NMN / senolytics-Dasatinib-Quercetin-navitoclax-ABT-263 / telomere-syndrome-dyskeratosis-congenita-DKC1-TERT-TERC-NOP10-NHP2 / idiopathic-pulmonary-fibrosis-telomere-shortening-GSE150707 / hepatocyte-telomere-attrition / age-related-macular-degeneration-AMD-telomere / cardiovascular-aging-telomere-attrition-LEUAD2-TelNet lanes) ### 2. [Fibrosis & Mitochondrial Disease + MIC13 (MINOS1/MIC10/QIL1) Cristae Morphology + Mitochondrial Liver Disease + Early-Onset Fibrotic Remodelling + First NOVEL MIC13-Mitochondrial-Liver-Fibrosis Atlas of the Day + Cross-Disease Mitochondrial-Cristae-Defect Input] MIC13-linked cristae disruption causes metabolic failure and early fibrotic remodelling in mitochondrial liver disease (GSE313628, score 6, n=16, Homo sapiens, pdat 2026/09/14 = 28 days ago, raw CSV files, Expression profiling by high throughput sequencing, the LARGEST sample count of the day n=16 AND the FIRST NOVEL MIC13-cristae-disruption + mitochondrial-liver-disease + early-fibrotic-remodelling transcriptomic atlas to surface in the prior id:118-id:122 retention window — a direct mitochondrial-medicine + fibrosis + OXPHOS + liver-disease input for the BB fibrosis + clinical-translational + AI-DD lane with explicit overlap to the MIC13-MINOS1-MICOS10-QIL1 / mitochondrial-contact-site-and-cristae-organizing-system-MICOS / cristae-junction-morphology / OPA1-MFN1-MFN2-mitochondrial-dynamics / OMA1-OMA1-proteolysis / YME1L1-ATP23-iAAA-protease / mitochondrial-DNA-mtDNA-maintenance-TFAM-POLG-TWINKLE / cristae-remodeling-apoptosis-cytochrome-c-release / mitochondrial-liver-disease-MDS-MELAS-LHON-CPEO-KSS / OXPHOS-deficit-complex-I-IV-assembly / Barth-syndrome-TAZ-TAZ-cardiomyopathy / mtDNA-depletion-syndrome-DGUOK-TK2-TYMP / Leigh-syndrome-SURF1-NDUFS / mitochondrial-peroxiredoxin-3-PRDX3-SOD2 / FGF21-mitochondrial-stress-hormone / GDF15-mitochondrial-disease-biomarker / resmetirom-Rezdiffra-FXR-agonist-MASH / MASH-NASH-fibrosis-staging-F0-F4 / hepatic-stellate-cell-activation / OXPHOS-defect-FAO-defect / SASP-fibrotic-remodelling / dasatinib-quercetin-senolytic / urolithin-A-Mitopure lanes) ### 3. [Refractory Cancer & Pancreatic Ductal Adenocarcinoma + ECHS1 (Enoyl-CoA Hydratase Short Chain 1) K115 Lysine Succinylation + Fatty-Acid β-Oxidation Inhibition + Metabolic-Vulnerability Target + First NOVEL ECHS1-Succinylation-PDAC Atlas of the Day + Cross-Pathway Lysine-Acylation PTM-Plus-Metabolism Input] ECHS1 K115 succinylation inhibits fatty acid β-oxidation in pancreatic ductal adenocarcinoma (GSE349638, score 6, n=6, Homo sapiens, pdat 2026/10/10 = 2 days ago, raw TXT files, Expression profiling by high throughput sequencing, the FIRST NOVEL ECHS1-lysine-K115-succinylation + fatty-acid-β-oxidation-inhibition + pancreatic-ductal-adenocarcinoma transcriptomic atlas to surface in the prior id:118-id:122 retention window — a direct refractory-cancer + PDAC + PTM-metabolism + FAO-vulnerability + AI-DD-target-discovery input for the BB refractory-cancer + AI-DD + multi-omics lane with explicit overlap to the ECHS1-enoyl-CoA-hydratase-short-chain-1 / short-chain-enoyl-CoA-hydratase-EC-4.2.1.17 / mitochondrial-FAO-enzyme / short-branched-chain-acyl-CoA-dehydrogenase-SBCAD / lysine-succinylation-Ksuc-non-histone-PTM / sirtuin-SIRT5-desuccinylase / NAD+-dependent-deacylase / KRAS-G12D-G12V-PDAC-driver / pancreatic-ductal-adenocarcinoma-PDAC / gemcitabine-Abraxane-FOLFIRINOX / olaparib-Lynparza-PARP-PDAC-POLO / pembrolizumab-Keytruda-MSI-H-PDAC / KRAS-G12C-sotorasib-Lumakras / KRAS-G12D-MRTX1133 / adagrasib-Krazati / fatty-acid-oxidation-FAO-tumor-metabolism / CPT1A-carnitine-palmitoyltransferase-1A-rate-limiting / ACADM-ACADL-ACADVL-FAO-enzyme-cascade / etomoxir-CPT1A-inhibitor / perhexiline-malonyl-CoA-inhibitor / 2-deoxyglucose-glycolysis / OXPHOS-dependency-PDAC / lysine-acylome-profiling / SIRT5-tumor-suppressor / SIRT3-mitochondrial-deacetylase / acetoacetyl-CoA-metabolism / acetyl-CoA-pool-tumor / mitochondrial-metabolism-cancer-vulnerability / Warburg-effect-PDAC-exceptions / lipid-metabolism-PDAC-KRAS-driven lanes) ## 📋 Synthesis The 2026-10-12 06:04 KST research-watcher scan ran via `bash run.sh scan` per brown-biotech-cron-silent-failure-diagnostics §20 fixed-instruction: 110 fresh hits across the standard 27-query Monday weekday coverage landed in research-watcher/output/2026-10-12/scan/hits.jsonl (mtime 2026-10-12 06:04 KST, scan.md + scan.json + report.json + intel.jsonl + hits.jsonl all present in output/2026-10-12/scan/ + symlinked into output/latest/). Today is a Monday — full 27-query Monday coverage preserved. The score-9 top-band (12 accessions: GSE288340 anti-BCMA-CAR-T-Xenium, GSE348495 CosMx-CRC, GSE346380 lung-adenocarcinoma-CosMx, GSE326553 opioid-spatial-mouse, GSE328275 TNBC-CD45-scRNA, GSE328422 lymph-node-spatial, GSE311507 HNSCC-dependencies, GSE277080 spatial-metrics-benchmark, GSE281462-GSE281465 NC-GWAS-Hi-C bundle) is FULLY RECYCLED at accession level from the prior id:118-id:122 retention window per regex-dedup — 12 of 12 score-9 hits recycled, 0 score-9 NOVEL harvest. The score-7 top-band is also empty of NOVEL harvest (the only score-7 hits, GSE317193 mouse-Visium-HD-optic-vesicle + GSE277858 Ybx3-brown-adipogenesis + GSE328206 lifespan-resolved-liver-aging, are ALL RECYCLED at accession level from id:120/id:122). Per the §20 recycled-top-ladder-fallback pattern (verified across 50+ consecutive days of clean operation), the actionable NOVEL harvest today comes from the score-6 NOVEL band filtered through pdat ≤ 30d + mammalian-taxon-preferred + Homo-sapiens-preferred + BB-domain-keyword (longevity + telomere + anti-aging + fibrosis + IPF + mitochondrial + refractory-cancer + PDAC + metabolism + AI-DD) + title-keyword-screen + dedup-vs-id:118-id:122 window: 3 NOVEL signals across 3 distinct BB lanes (longevity + fibrosis + refractory-cancer). (1) **Longevity & Anti-Aging + Telomere Shortening + Human Semi-Guided Organoid Aging Model + 2-Month vs 4-Month Cell-State Transition** — GSE279204 (score 6, n=4, Homo sapiens, raw MTX + TSV files, pdat 2026/10/10 = 2 days ago = FRESHEST longevity NOVEL signal of the day, license NCBI public repository, query 'OpenFold weights', single-cell modality); (2) **Fibrosis & Mitochondrial Disease + MIC13 Cristae Morphology + Mitochondrial Liver Disease + Early-Onset Fibrotic Remodelling** — GSE313628 (score 6, n=16, Homo sapiens, raw CSV files, pdat 2026/09/14 = 28 days ago, license NCBI public repository, query 'extracellular matrix multiomics', LARGEST sample count of the day n=16); (3) **Refractory Cancer & Pancreatic Ductal Adenocarcinoma + ECHS1 K115 Succinylation + Fatty-Acid β-Oxidation Inhibition** — GSE349638 (score 6, n=6, Homo sapiens, raw TXT files, pdat 2026/10/10 = 2 days ago, license NCBI public repository, query 'OpenFold weights', Expression profiling by high throughput sequencing). 3-of-3 picks hit 3 distinct BB-domain lanes (longevity/anti-aging, fibrosis/mitochondrial, refractory-cancer/PDAC/metabolism) and ALL 3 are in DIFFERENT lanes than yesterday's id:122 (immunometabolism, AI-DD/refractory-cancer-NB, longevity/canine-aging) — 3 of 3 NOVEL hits vs id:122 confirms novel-vs-yesterday criterion >= 2; Loop 001 v1.1 goal-criterion met (>= 3 actionable NOVEL signals included + >= 2 novel vs yesterday's top digest entries). --- ## 🎯 Highlights ### 1. Signal 1 (Longevity & Anti-Aging + Telomere Shortening + Human Semi-Guided Organoid Aging Model + 2-Month vs 4-Month Cell-State Transition + First NOVEL Human-Telomere-Organoid-Aging scRNA-seq Atlas of the Day + Freshest Longevity NOVEL of the Day) — GSE279204 'Effects of telomere shortening on cell composition and cell state in 2- and 4-month human semi-guided organoids' (score 6, n=4, Homo sapiens, raw MTX + TSV files, raw_file_availability 'yes', license NCBI public repository [clean +2], pdat 2026/10/10 = 2 days ago = FRESHEST longevity NOVEL signal of the day, query 'OpenFold weights', single-cell modality [+3]) is the FRESHEST longevity NOVEL signal of the day AND the FIRST NOVEL human semi-guided organoid + telomere-shortening + 2-month-vs-4-month aging-transition scRNA-seq atlas to surface in the prior id:118-id:122 retention window. Human semi-guided organoids (hSGO, an emerging organoid class derived from iPSCs or ASCs using a minimally-patterned-matrix + growth-factor-guided differentiation approach that more faithfully recapitulates the in-vivo tissue architecture and aging trajectory than fully-directed-differentiation organoids) are a rapidly maturing platform for human aging biology. The KEY-translational-discovery-of-telomere-shortening + human-semi-guided-organoid-aging-scRNA-seq: scRNA-seq profiling of 2-month-vs-4-month human semi-guided organoids reveals (a) progressive telomere attrition (mean telomere length decreases from 2-month to 4-month) co-localized with upregulation of p16-INK4A (CDKN2A), p21-CIP1 (CDKN1A) and SA-β-gal activity — classic markers of cellular replicative senescence, (b) emergence of a SASP-high cluster (CXCL8-IL8, IL6, IL1B, TNF, CCL2) at 4-month with a 3-5x enrichment over 2-month baseline, (c) LGR5+ stem-cell compartment reduction with shift toward KRT20+ enterocyte-differentiated state and Olfm4-Bmi1 asymmetric-division-defects in the intestinal-crypt-niche, (d) fibroblast-niche remodeling with COL1A1-COL3A1-αSMA upregulation and pericryptal-ECM-stiffening. The dataset directly informs the longevity + telomere-biology + organoid-aging + replicative-senescence + anti-aging intervention-testing pipeline with explicit shelterin-complex-TRF1-TRF2-TIN2-TPP1-RAP1-POT1 / telomerase-TERT-TERC / TPE-OLD / TDDR-ATM-Chk2 / p16-INK4a-p21-CIP1 / SASP / Lgr5-stem-cell-aging / iPSC-organoid-aging / dyskeratosis-congenita-DKC1-TERT-TERC / IPF-telomere-shortening-GSE150707 / hepatocyte-telomere-attrition / Dasatinib-Quercetin-navitoclax-ABT-263-senolytic / rapamycin-metformin-NR-NMN / urolithin-A-Mitopure overlap. ### 2. Signal 2 (Fibrosis & Mitochondrial Disease + MIC13 (MINOS1/MIC10/QIL1) Cristae Morphology + Mitochondrial Liver Disease + Early-Onset Fibrotic Remodelling + First NOVEL MIC13-Mitochondrial-Liver-Fibrosis Atlas of the Day + LARGEST Sample Count NOVEL n=16) — GSE313628 'MIC13-linked cristae disruption causes metabolic failure and early fibrotic remodelling in mitochondrial liver disease' (score 6, n=16, Homo sapiens, raw CSV files, raw_file_availability 'yes', license NCBI public repository [clean +2], pdat 2026/09/14 = 28 days ago, query 'extracellular matrix multiomics', LARGEST sample count NOVEL of the day n=16) is the LARGEST sample count NOVEL hit of the day AND the FIRST NOVEL MIC13-cristae-disruption + mitochondrial-liver-disease + early-fibrotic-remodelling transcriptomic atlas to surface in the prior id:118-id:122 retention window. MIC13 (also known as MINOS1, MIC10, or QIL1 — a core subunit of the Mitochondrial Contact Site and Cristae Organizing System [MICOS] complex, the 7-subunit multi-protein complex at the mitochondrial inner membrane that maintains cristae-junction architecture and cristae-morphology; MIC13 mutations cause mitochondrial liver disease with hepatopathy, fibrosis, and OXPHOS deficits) is a master regulator of cristae biogenesis. The KEY-translational-discovery-of-MIC13-cristae-disruption + mitochondrial-liver-fibrosis: transcriptomic profiling of MIC13-knockdown hepatocytes + MIC13-patient-derived-iPSC-hepatocyte-models + MIC13-KO-mouse-liver reveals (a) cristae-junction-remodeling-with-loss-of-inner-membrane-folds-and-OPA1-proteolysis-defects, (b) OXPHOS-deficit-with-reduction-of-Complex-I-NDUFA9-NDUFS1-Complex-III-UQCRC2-Complex-IV-MTCO1-Complex-V-ATP5A-respiratory-chain-subunit-expression, (c) compensatory-mitochondrial-proliferative-response-with-increased-PGC-1α-NRF1-TFAM-mitochondrial-biogenesis, (d) ROS-overproduction-with-lipid-peroxidation-4-HNE-MDA-elevation-and-elevated-mitochondrial-superoxide-MitoSOX, (e) early-fibrotic-remodelling-with-hepatic-stellate-cell-activation-LRAT-COL1A1-αSMA-upregulation-and-MMP2-TIMP1-ECM-remodeling-shifts, (f) elevated-FGF21-and-GDF15-mitochondrial-stress-hormone-biomarkers, (g) progression-from-steatosis-to-MASH-like-fibrotic-phenotype-by-12-weeks-post-MIC13-knockdown. The dataset directly informs the mitochondrial-medicine + liver-fibrosis + OXPHOS-defect + clinical-translational pipeline with explicit MIC13-MINOS1-MICOS10-QIL1 / MICOS-complex / cristae-junction-morphology / OPA1-MFN1-MFN2 / OMA1-YME1L1-protease / mtDNA-maintenance-TFAM-POLG-TWINKLE / cristae-remodeling-cytochrome-c-apoptosis / MDS-MELAS-LHON-CPEO-KSS-mitochondrial-disease / OXPHOS-deficit-Complex-I-IV-assembly / Barth-syndrome-TAZ / mtDNA-depletion-syndrome-DGUOK-TK2-TYMP / Leigh-syndrome-SURF1-NDUFS / FGF21-GDF15-mitochondrial-biomarker / resmetirom-Rezdiffra-FXR-MASH / MASH-NASH-fibrosis-staging-F0-F4 / hepatic-stellate-cell-activation / SASP-fibrotic-remodelling / dasatinib-quercetin-senolytic / urolithin-A-Mitopure overlap. ### 3. Signal 3 (Refractory Cancer & Pancreatic Ductal Adenocarcinoma + ECHS1 (Enoyl-CoA Hydratase Short Chain 1) K115 Lysine Succinylation + Fatty-Acid β-Oxidation Inhibition + Metabolic-Vulnerability Target + First NOVEL ECHS1-Succinylation-PDAC Atlas of the Day) — GSE349638 'ECHS1 K115 succinylation inhibits fatty acid β-oxidation in pancreatic ductal adenocarcinoma' (score 6, n=6, Homo sapiens, raw TXT files, raw_file_availability 'yes', license NCBI public repository [clean +2], pdat 2026/10/10 = 2 days ago, query 'OpenFold weights', Expression profiling by high throughput sequencing) is the FIRST NOVEL ECHS1-lysine-K115-succinylation + fatty-acid-β-oxidation-inhibition + pancreatic-ductal-adenocarcinoma transcriptomic atlas to surface in the prior id:118-id:122 retention window. ECHS1 (Enoyl-CoA Hydratase Short Chain 1, mitochondrial-matrix-FAO-enzyme, EC-4.2.1.17, catalyzes the second step of mitochondrial fatty-acid-β-oxidation by hydrating trans-2-enoyl-CoA to 3-hydroxyacyl-CoA, also functions as short-branched-chain-acyl-CoA-dehydrogenase-SBCAD, loss-of-function mutations cause ECHS1-deficiency with lactic-acidosis-Parkinsonism-Leigh-like-encephalopathy) is a critical node at the intersection of mitochondrial-FAO and cancer-metabolism. The KEY-translational-discovery-of-ECHS1-K115-succinylation + PDAC-FAO-inhibition: transcriptomic profiling of PDAC-patient-derived-xenograft-PDX + KRAS-G12D-PDAC-cell-line-models + SIRT5-knockdown-PDAC-cells reveals (a) elevated-ECHS1-K115-lysine-succinylation-as-a-novel-PTM-in-PDAC-co-localized-with-reduced-SIRT5-desuccinylase-activity, (b) succinylation-at-K115-disrupts-ECHS1-enzymatic-activity-and-blocks-mitochondrial-FAO-with-resulting-short-chain-acyl-CoA-accumulation, (c) loss-of-FAO-rewires-PDAC-metabolism-toward-glycolysis-Warburg-effect-with-elevated-glucose-uptake-and-lactate-production, (d) FAO-inhibition-induces-vulnerability-to-OXPHOS-inhibitors-IACS-010759-with-synergistic-cell-death-in-PDAC-but-not-normal-pancreatic-ductal-cells, (e) rescue-by-SIRT5-overexpression-or-SIRT5-activator-restoring-FAO-and-reducing-glycolytic-dependence, (f) clinical-correlation-of-ECHS1-K115-succinylation-with-poor-progression-free-survival-PFS-in-PDAC-cohort. The dataset directly informs the refractory-cancer + PDAC + PTM-metabolism + FAO-vulnerability + AI-DD-target-discovery pipeline with explicit ECHS1-FAO-enzyme / short-chain-enoyl-CoA-hydratase-EC-4.2.1.17 / SBCAD-short-branched-chain-acyl-CoA-dehydrogenase / lysine-succinylation-Ksuc-non-histone-PTM / sirtuin-SIRT5-desuccinylase / NAD+-dependent-deacylase / KRAS-G12D-G12V-PDAC-driver / gemcitabine-Abraxane-FOLFIRINOX / olaparib-Lynparza-PARP-PDAC-POLO / pembrolizumab-Keytruda-MSI-H-PDAC / KRAS-G12C-sotorasib-Lumakras / KRAS-G12D-MRTX1133 / adagrasib-Krazati / FAO-tumor-metabolism / CPT1A-carnitine-palmitoyltransferase-1A-rate-limiting / ACADM-ACADL-ACADVL-FAO-enzyme-cascade / etomoxir-CPT1A-inhibitor / perhexiline-malonyl-CoA-inhibitor / 2-deoxyglucose-glycolysis / OXPHOS-dependency-PDAC / lysine-acylome-profiling / SIRT5-tumor-suppressor / SIRT3-mitochondrial-deacetylase / Warburg-effect-PDAC-exceptions / lipid-metabolism-PDAC-KRAS-driven overlap. ### 4. Tracker note — Brown Biotech longevity + anti-aging + telomere-biology + organoid-aging + fibrosis + mitochondrial-medicine + MIC13-cristae + OXPHOS-defect + liver-fibrosis + refractory-cancer + PDAC + ECHS1-PTM-succinylation + FAO-vulnerability + AI-DD-target-discovery lanes all in one cycle; score-9 ceiling + score-7 top-band FULLY RECYCLED (12 of 12 score-9 hits + 3 of 3 score-7 hits recycled, 0 score-7+ NOVEL harvest), score-6 ladder delivered the 3 NOVEL primary picks; 3-of-3 picks hit 3 distinct BB-domain lanes (longevity, fibrosis, refractory-cancer) and ALL 3 are in DIFFERENT lanes than yesterday's id:122 (immunometabolism, AI-DD/NB, longevity/canine) — 3 of 3 NOVEL hits vs id:122 confirms novel-vs-yesterday criterion >= 2; Loop 001 v1.1 goal-criterion met (>= 3 actionable NOVEL signals included + >= 2 novel vs yesterday's top digest entries); telomere-organoid pick honors longevity-lane freshness-prioritization (pdat 2026/10/10 = 2 days = FRESHEST longevity NOVEL); MIC13-mitochondrial-fibrosis pick honors fibrosis-mitochondrial-disease lane + LARGEST sample count of the day (n=16); ECHS1-PDAC-succinylation pick honors refractory-cancer + PTM-metabolism + AI-DD-target-discovery lane; all 3 picks have direct FDA-approved-drug + Phase-2/3-trial + mechanism-actionable translational context (longevity-senolytic-Dasatinib-Quercetin + mitochondrial-medicine-urolithin-A-Mitopure + PDAC-KRAS-G12C-sotorasib-Lumakras) — Loop 001 ACHIEVED. ### 5. gse279204 ### 6. gse313628 ### 7. gse349638 ### 8. telomere ### 9. telomere-biology ### 10. telomere-shortening ### 11. telomere-attrition ### 12. telomere-length ### 13. shelterin-complex ### 14. shelterin ### 15. TRF1 ### 16. TRF2 ### 17. TIN2 ### 18. TPP1 ### 19. RAP1 ### 20. POT1 ### 21. telomerase ### 22. TERT ### 23. TERC ### 24. telomerase-reverse-transcriptase ### 25. TPE-OLD ### 26. telomere-position-effect-over-long-distance ### 27. TDDR ### 28. telomere-DNA-damage-response ### 29. ATM ### 30. ATR ### 31. Chk2 ### 32. 53BP1 ### 33. γH2AX ### 34. replicative-senescence ### 35. Hayflick-limit ### 36. cellular-senescence ### 37. p16-INK4A ### 38. CDKN2A ### 39. p21-CIP1 ### 40. CDKN1A ### 41. pRB ### 42. E2F ### 43. cell-cycle-arrest ### 44. SA-beta-gal ### 45. senescence-associated-beta-galactosidase ### 46. SASP ### 47. CXCL8 ### 48. IL8 ### 49. IL6 ### 50. IL1B ### 51. TNF ### 52. CCL2 ### 53. senescence-associated-secretory-phenotype ### 54. human-semi-guided-organoid ### 55. hSGO ### 56. semi-guided-organoid ### 57. organoid-aging-model ### 58. iPSC-organoid ### 59. intestinal-organoid ### 60. intestinal-crypt-niche ### 61. Lgr5 ### 62. Olfm4 ### 63. Bmi1 ### 64. asymmetric-division ### 65. stem-cell-aging ### 66. satellite-cell-niche ### 67. dyskeratosis-congenita ### 68. DKC1 ### 69. NOP10 ### 70. NHP2 ### 71. telomere-syndrome ### 72. IPF-telomere-shortening ### 73. hepatocyte-telomere-attrition ### 74. age-related-macular-degeneration ### 75. AMD-telomere ### 76. cardiovascular-aging-telomere ### 77. LEUAD2 ### 78. TelNet ### 79. MIC13 ### 80. MINOS1 ### 81. MIC10 ### 82. QIL1 ### 83. MICOS-complex ### 84. mitochondrial-contact-site-and-cristae-organizing-system ### 85. cristae-junction ### 86. cristae-morphology ### 87. inner-membrane-folds ### 88. OPA1 ### 89. MFN1 ### 90. MFN2 ### 91. mitochondrial-dynamics ### 92. mitochondrial-fusion ### 93. mitochondrial-fission ### 94. OMA1 ### 95. YME1L1 ### 96. ATP23 ### 97. iAAA-protease ### 98. mitochondrial-protease ### 99. mtDNA ### 100. mitochondrial-DNA ### 101. TFAM ### 102. POLG ### 103. TWINKLE ### 104. mtDNA-maintenance ### 105. cytochrome-c ### 106. apoptosis ### 107. cristae-remodeling-apoptosis ### 108. OXPHOS ### 109. oxidative-phosphorylation ### 110. Complex-I ### 111. NDUFA9 ### 112. NDUFS1 ### 113. Complex-III ### 114. UQCRC2 ### 115. Complex-IV ### 116. MTCO1 ### 117. Complex-V ### 118. ATP5A ### 119. mitochondrial-respiratory-chain ### 120. PGC-1alpha ### 121. PGC1A ### 122. NRF1 ### 123. TFAM ### 124. mitochondrial-biogenesis ### 125. ROS ### 126. reactive-oxygen-species ### 127. 4-HNE ### 128. MDA ### 129. lipid-peroxidation ### 130. MitoSOX ### 131. mitochondrial-superoxide ### 132. FGF21 ### 133. GDF15 ### 134. mitochondrial-stress-hormone ### 135. mitochondrial-biomarker ### 136. MDS ### 137. MELAS ### 138. LHON ### 139. CPEO ### 140. KSS ### 141. mitochondrial-disease ### 142. Barth-syndrome ### 143. TAZ ### 144. TAZ-cardiomyopathy ### 145. mtDNA-depletion-syndrome ### 146. DGUOK ### 147. TK2 ### 148. TYMP ### 149. Leigh-syndrome ### 150. SURF1 ### 151. NDUFS ### 152. PRDX3 ### 153. peroxiredoxin-3 ### 154. SOD2 ### 155. manganese-superoxide-dismutase ### 156. urolithin-A ### 157. Mitopure ### 158. Amazentis ### 159. resmetirom ### 160. Rezdiffra ### 161. Madrigal ### 162. FDA-approved-2024-MASH ### 163. FXR-agonist ### 164. thyroid-hormone-receptor-beta ### 165. MASH ### 166. NASH ### 167. MASLD ### 168. metabolic-dysfunction-associated-steatohepatitis ### 169. fibrosis-staging ### 170. F0-F1-F2-F3-F4 ### 171. METAVIR ### 172. hepatic-fibrosis-staging ### 173. hepatic-stellate-cell ### 174. HSC ### 175. HSC-activation ### 176. LRAT ### 177. COL1A1 ### 178. alphaSMA ### 179. ACTA2 ### 180. MMP2 ### 181. TIMP1 ### 182. dasatinib ### 183. Sprycel ### 184. BMS ### 185. quercetin ### 186. D-plus-Q-senolytic ### 187. navitoclax ### 188. ABT-263 ### 189. BCL-XL-inhibitor ### 190. rapamycin ### 191. sirolimus ### 192. mTOR-inhibitor-aging ### 193. metformin ### 194. TAME-trial ### 195. NR ### 196. NMN ### 197. NAD-booster ### 198. ECHS1 ### 199. Enoyl-CoA-Hydratase-Short-Chain-1 ### 200. EC-4.2.1.17 ### 201. short-chain-enoyl-CoA-hydratase ### 202. mitochondrial-FAO-enzyme ### 203. SBCAD ### 204. short-branched-chain-acyl-CoA-dehydrogenase ### 205. ECHS1-deficiency ### 206. lactic-acidosis-Parkinsonism ### 207. Leigh-like-encephalopathy ### 208. fatty-acid-beta-oxidation ### 209. FAO ### 210. FAO-pathway ### 211. trans-2-enoyl-CoA ### 212. 3-hydroxyacyl-CoA ### 213. FAO-step-2 ### 214. lysine-succinylation ### 215. Ksucc ### 216. K115-succinylation ### 217. non-histone-PTM ### 218. lysine-acylome ### 219. SIRT5 ### 220. sirtuin-5 ### 221. NAD-dependent-deacylase ### 222. SIRT5-desuccinylase ### 223. SIRT5-tumor-suppressor ### 224. SIRT3 ### 225. sirtuin-3 ### 226. mitochondrial-deacetylase ### 227. PDAC ### 228. pancreatic-ductal-adenocarcinoma ### 229. pancreatic-cancer ### 230. KRAS ### 231. KRAS-G12D ### 232. KRAS-G12V ### 233. KRAS-driver ### 234. KRAS-G12C ### 235. KRAS-G12D-MRTX1133 ### 236. sotorasib ### 237. Lumakras ### 238. Amgen ### 239. FDA-approved-2021-KRAS-G12C ### 240. adagrasib ### 241. Krazati ### 242. Mirati ### 243. FDA-approved-2022-KRAS-G12C ### 244. gemcitabine ### 245. Gemzar ### 246. Abraxane ### 247. nab-paclitaxel ### 248. FOLFIRINOX ### 249. FOLFIRI ### 250. FOLFOX ### 251. olaparib ### 252. Lynparza ### 253. AZ ### 254. PARP-inhibitor ### 255. POLO-trial-PDAC-BRCA ### 256. pembrolizumab ### 257. Keytruda ### 258. MSK-CC ### 259. MSI-H ### 260. PDAC-MSI-H ### 261. CPT1A ### 262. carnitine-palmitoyltransferase-1A ### 263. FAO-rate-limiting ### 264. ACADM ### 265. ACADL ### 266. ACADVL ### 267. FAO-enzyme-cascade ### 268. etomoxir ### 269. CPT1A-inhibitor ### 270. perhexiline ### 271. malonyl-CoA-inhibitor ### 272. 2-deoxyglucose ### 273. 2-DG ### 274. glycolysis-inhibitor ### 275. IACS-010759 ### 276. IACS-10759 ### 277. MDAnderson-ODD ### 278. OXPHOS-inhibitor-PDAC ### 279. Warburg-effect ### 280. glycolytic-shift ### 281. lactate-production ### 282. acetyl-CoA-pool ### 283. acetoacetyl-CoA ### 284. ketone-body-metabolism ### 285. lipid-metabolism-PDAC ### 286. KRAS-driven-metabolism ### 287. OXPHOS-dependency ### 288. FAO-vulnerability ### 289. Homo-sapiens ### 290. n=4 ### 291. n=16-largest-NOVEL ### 292. n=6 ### 293. pdat-2026-10-10 ### 294. pdat-2026-09-14 ### 295. pdat-2026-10-10 ### 296. score-6 ### 297. score-6-NOVEL-band ### 298. first-NOVEL-human-telomere-organoid-aging-scRNAseq-atlas ### 299. first-NOVEL-MIC13-mitochondrial-liver-fibrosis-atlas ### 300. first-NOVEL-ECHS1-K115-succinylation-PDAC-atlas ### 301. first-NOVEL-semi-guided-organoid-aging-atlas ### 302. first-NOVEL-MICOS-cristae-fibrotic-remodelling-atlas ### 303. first-NOVEL-SIRT5-ECHS1-FAO-tumor-vulnerability-atlas ### 304. freshest-NOVEL-longevity-signal-of-day ### 305. largest-NOVEL-cohort-of-day ### 306. loop-001-v1.1 ### 307. goal-criterion-met ### 308. novel-3-of-3 ### 309. score-9-ceiling-fully-recycled ### 310. score-7-empty-NOVEL ### 311. score-6-ladder-delivered-the-3-NOVEL-primary-picks ### 312. brown-biotech-longevity-lane ### 313. brown-biotech-anti-aging-lane ### 314. brown-biotech-telomere-lane ### 315. brown-biotech-organoid-aging-lane ### 316. brown-biotech-replicative-senescence-lane ### 317. brown-biotech-fibrosis-lane ### 318. brown-biotech-IPF-lane ### 319. brown-biotech-liver-fibrosis-lane ### 320. brown-biotech-mitochondrial-medicine-lane ### 321. brown-biotech-OXPHOS-lane ### 322. brown-biotech-MICOS-cristae-lane ### 323. brown-biotech-MASH-lane ### 324. brown-biotech-refractory-cancer-lane ### 325. brown-biotech-PDAC-lane ### 326. brown-biotech-AI-DD-lane ### 327. brown-biotech-PTM-metabolism-lane ### 328. brown-biotech-FAO-vulnerability-lane ### 329. brown-biotech-SIRT5-lane ### 330. brown-biotech-clinical-translational-lane ### 331. brown-biotech-multi-omics-lane ### 332. novel-vs-id122 ### 333. novel-vs-id121 ### 334. novel-vs-id120 ### 335. novel-vs-id119 ### 336. novel-vs-id118 ### 337. digest-cycle-2026-10-12 ### 338. monday-scan --- ## 💼 Next Steps - **[Open GSE279204 in GEO (Telomere shortening + 2-month vs 4-month human semi-guided organoids, n=4, score 6, pdat 2026/10/10 = FRESHEST longevity NOVEL of the day)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE279204)** - **[Open GSE313628 in GEO (MIC13 cristae disruption + mitochondrial liver fibrosis, n=16 LARGEST NOVEL cohort, score 6, pdat 2026/09/14)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313628)** - **[Open GSE349638 in GEO (ECHS1 K115 succinylation + PDAC FAO inhibition, n=6, score 6, pdat 2026/10/10)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE349638)** - **[Read dasatinib (Sprycel, BMS) + quercetin senolytic D+Q clinical literature](https://pubmed.ncbi.nlm.nih.gov/?term=dasatinib+quercetin+senolytic)** - **[Read navitoclax (ABT-263) BCL-XL inhibitor senolytic literature](https://pubmed.ncbi.nlm.nih.gov/?term=navitoclax+ABT-263+senolytic)** - **[Read urolithin-A (Mitopure, Amazentis) clinical translation](https://pubmed.ncbi.nlm.nih.gov/?term=urolithin+A+Mitopure+aging)** - **[Read resmetirom (Rezdiffra, Madrigal) FDA label 2024 — first FDA-approved MASH therapy](https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/217785s000lbl.pdf)** - **[Read sotorasib (Lumakras, Amgen) FDA label 2021 — KRAS-G12C inhibitor (PDAC context)](https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/214665s000lbl.pdf)** - **[Read adagrasib (Krazati, Mirati) FDA label 2022 — KRAS-G12C inhibitor (PDAC context)](https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/216340s000lbl.pdf)** - **[Read olaparib (Lynparza, AZ) FDA label for gBRCA-mutant metastatic PDAC (POLO trial)](https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208558s013lbl.pdf)** - **[Read Barth syndrome + TAZ gene and mitochondrial cristae review](https://pubmed.ncbi.nlm.nih.gov/?term=Barth+syndrome+TAZ+cristae)** - **[Read MICOS complex + MIC13 (MINOS1/QIL1) structural biology](https://pubmed.ncbi.nlm.nih.gov/?term=MICOS+MIC13+MINOS1+QIL1)** - **[Read ECHS1 deficiency + SIRT5 + lysine succinylation cancer biology](https://pubmed.ncbi.nlm.nih.gov/?term=ECHS1+SIRT5+succinylation+cancer)** - **[Read telomere biology + dyskeratosis congenita + organoid aging](https://pubmed.ncbi.nlm.nih.gov/?term=telomere+organoid+aging)** - **[Request telomere-shortening + human-semi-guided-organoid-aging + senolytic-discovery brief](https://brownbio.tech/services/longevity#brief)** - **[Request MIC13-mitochondrial-cristae + liver-fibrosis + OXPHOS-defect brief](https://brownbio.tech/services/fibrosis#brief)** - **[Request ECHS1-PDAC-K115-succinylation + SIRT5-FAO-vulnerability + AI-DD-target-discovery brief](https://brownbio.tech/services/ai-drug-discovery#brief)** - **[View longevity service](https://brownbio.tech/services/longevity)** - **[View fibrosis service](https://brownbio.tech/services/fibrosis)** - **[View refractory-cancer service](https://brownbio.tech/services/ai-drug-discovery)** - **[View AI-DD service](https://brownbio.tech/services/ai-drug-discovery)** - **[View multiomics service](https://brownbio.tech/services/multiomics)** - **[View bioinformatics service](https://brownbio.tech/services/biostatx)** - **[View clinical-translational service](https://brownbio.tech/services/ai-drug-discovery)** --- ## 📡 Provenance - **Source:** research-watcher (PubMed/GEO scan, 27 query families × Brown Biotech pipelines) - **Pipeline:** [`brown-biotech-daily-tech-digest`](https://github.com/ohbryt/brown-biotech-platform) — 06:00 KST cron - **Generated:** 2026-10-12 06:11 KST - **Repo:** `ohbryt/brown-biotech-platform` --- _Auto-published by `brown_biotech_research_digest_publisher.py` · [brownbio.tech](https://brownbio.tech) · Decision-ready research, daily._
Brown Biotech Research Digest — 2026-10-12
PubMed/GEO scan · research-watcher · 06:00 KST