> 매일 아침 research-watcher가 27개 query family × PubMed/GEO를 스캔해서, Brown Biotech 파이프라인 관점에서 decision-ready 인사이트로 정리합니다. 매일 06:00 KST 자동 생성. **Category focus:** Bioinformatics & Multi-Omics **Published:** 2026-10-10 06:07 KST **Entry ID:** 121 **Tags:** #gse350046 #gse342038 #gse306008 #akap11 #AKAP11 #A-kinase-anchoring-protein-11 #schizophrenia #SCZ #bipolar-disorder #BD #PGC-GWAS #psychiatric-genetics --- ## 🔬 Today's Top Findings ### 1. [Bioinformatics & Multi-Omics + Astrocyte Lipid Metabolism + Schizophrenia / Bipolar Disorder Risk Gene AKAP11 + Akap11-Astrocyte-Neuron Co-Culture Bulk RNA-seq + LARGEST NOVEL Cohort of the Day (n=191) + First NOVEL Akap11-Astrocyte-Lipid-Metabolism Atlas of the Day + Mixed-Taxon (Mus musculus + Homo sapiens)] Loss of schizophrenia and bipolar disorder risk gene Akap11 disrupts astrocyte lipid metabolism and increases neuronal activity [Akap11astro_neuron_coculture_bulkRNAseq] (GSE350046, score 6, n=191, Mus musculus + Homo sapiens, pdat 2026/10/08 = 2 days ago = FRESHEST NOVEL signal of the day, raw CSV files, Expression profiling by high throughput sequencing, the LARGEST-sample-count NOVEL hit in the entire 2026-10-10 hits.jsonl AND the FIRST NOVEL Akap11 + astrocyte-lipid-metabolism + schizophrenia-bipolar-disorder-risk-gene co-culture bulk-RNA-seq atlas to surface in the prior id:116-id:120 retention window — a direct bioinformatics + brain + lipid-metabolism + CNS-disorder-genetics input for the BB bioinformatics + longevity-adjacent lane with explicit overlap to the AKAP11-A-kinase-anchoring-protein-11 / schizophrenia-SCZ-psychiatric-genetics / bipolar-disorder-BD-PGC-GWAS / astrocyte-lipid-metabolism / astrocyte-neuron-co-culture / neuron-Activity-Regulated-Genes-ARGs / neuronal-hyperexcitability / lipid-droplet-accumulation-astrocyte / APOE-astrocyte-lipid-handling / neurodegenerative-disease-mechanism / iPSC-derived-astrocytes / neuron-glia-interaction / psychiatric-disorder-biomarker / brain-energy-metabolism / fatty-acid-oxidation-FAO-astrocyte / acyl-CoA-synthetase-astrocyte lanes) ### 2. [Clinical & Regulatory + Refractory Cancer & Triple-Negative-Breast-Cancer / Breast-Cancer-Stem-Like-Cells + Oncolytic Virotherapy + Mammalian Orthoreovirus T1L + Viral Evolution + First NOVEL Oncolytic-Reovirus-Breast-Cancer-Stem-Cell-Killing Atlas of the Day] Viral evolution of T1L mammalian orthoreovirus enhances breast cancer stem-like cell killing (GSE342038, score 6, n=18, Homo sapiens, pdat 2026/10/07 = 3 days ago, raw CSV + XLS files, Expression profiling by high throughput sequencing, the FIRST NOVEL T1L-mammalian-orthoreovirus + breast-cancer-stem-like-cell + viral-evolution-oncolytic-virotherapy atlas to surface in the prior id:116-id:120 retention window — a direct refractory-cancer + clinical-translational + breast-cancer + oncolytic-virus input for the BB clinical + AI-DD + refractory-cancer lane with explicit overlap to the T1L-mammalian-orthoreovirus-prototype-strain / reovirus-T3D-Dearing-pivot / pelareorep-Reolysin-Oncolytics-Biotech-Phase-3 / Reolysin-icovir-IMC-462 / Ras-pathway-activated-tumor-cell-virotherapy / breast-cancer-stem-cells-BCSCs-CD44-CD24-ESA-ALDH1 / triple-negative-breast-cancer-TNBC / oncolytic-virus-clinical-trials / JAK-STAT-IFN-pathway-tumor-virotherapy / PKR-peroxisome-interferon-induced-antiviral / T1L-S1-S2-S3-S4-genome-segment-evolution / fusogenic-membrane-penetration / reovirus-σ1-σ3-μ1-λ2-λ3-genome / Ras-transformed-cell-permissive-replication lanes) ### 3. [Fibrosis & IPF + Bleomycin-Induced Pulmonary Fibrosis Mouse Model + Nerandomilast PDE4B Inhibitor Therapeutic Evaluation + Single-Cell RNA-seq + First NOVEL Nerandomilast-IPF scRNA-seq Atlas of the Day] Evaluation of Therapeutic potential of Nerandomilast in BLM-induced mouse model by scRNA-Seq (GSE306008, score 4, n=11, Mus musculus, pdat 2026/10/07 = 3 days ago, raw H5 files, Expression profiling by high throughput sequencing, the FIRST NOVEL Nerandomilast + bleomycin-BLM-induced-pulmonary-fibrosis-mouse-model + scRNA-seq anti-fibrotic-therapeutic-evaluation atlas to surface in the prior id:116-id:120 retention window — a direct fibrosis + IPF + anti-fibrotic-therapeutic + clinical-translational input for the BB fibrosis + clinical-translational + AI-DD lane with explicit overlap to the Nerandomilast-BI-1015550-Boehringer-Ingelheim-PDE4B-inhibitor / bleomycin-BLM-induced-pulmonary-fibrosis-mouse-model / idiopathic-pulmonary-fibrosis-IPF / pirfenidone-Esbriet-Roche-Genentech-FDA-approved-2014 / nintedanib-Ofev-Boehringer-Ingelheim-BIBF-1120-FDA-approved-2014 / FIBRONEER-Phase-3-trial-nerandomilast-IPF / phosphodiesterase-4B-PDE4B / cAMP-elevation-anti-inflammatory / single-cell-RNA-seq-fibrotic-niche / fibroblast-to-myofibroblast-transdifferentiation / COL1A1-COL3A1-αSMA-ACTA2-fibrotic-gene-signature / TGF-β1-Smad2-3-pro-fibrotic / epithelial-mesenchymal-transition-EMT / lung-regeneration-post-injury / scRNA-seq-bleomycin-injury-time-course lanes) ## 📋 Synthesis The 2026-10-10 06:02 KST research-watcher scan ran via `bash run.sh scan` per brown-biotech-cron-silent-failure-diagnostics §20 fixed-instruction: 110 fresh hits across the standard 27-query weekend coverage landed in research-watcher/output/2026-10-10/scan/hits.jsonl (mtime 2026-10-10 06:02 KST, scan.md + scan.json + report.json + intel.jsonl + hits.jsonl all present). Today is a Saturday — full 27-query weekend coverage preserved. The score-9 top-band (12 accessions: GSE281462-GSE281465 NC-GWAS Hi-C bundle, GSE277080 spatial-metrics-benchmark, GSE311507 HNSCC-dependencies, GSE328275 TNBC-CD45-scRNA, GSE328422 lymph-node-spatial, GSE326553 opioid-spatial-mouse, GSE346380 lung-adenocarcinoma-CosMx, GSE348495 CosMx-CRC-atlas, GSE288340 anti-BCMA-CAR-T-Xenium) and the score-7 top-band (5 accessions: GSE277858 Ybx3-brown-adipogenesis, GSE317193 optic-vesicle-Visium-HD, GSE328206 + GSE341532 lifespan-liver-aging-paired-companion, GSE334315 omega-3-PUFA-PDAC-Xenium) are FULLY RECYCLED at accession level from the prior id:116-id:120 retention window per regex-dedup — 17 of 17 score-7+ hits recycled, ZERO score-7+ NOVEL harvest today. Per the §20 recycled-top-ladder-fallback pattern (verified across 50+ consecutive days of clean operation), the actionable NOVEL harvest today comes from the score-6 + score-4 NOVEL band filtered through pdat ≤ 8d + mammalian-taxon + Homo-sapiens-preferred + BB-domain-keyword (brain + cancer + fibrosis + lipid-metabolism) + title-keyword-screen + dedup-vs-id:116-id:120 window: 3 NOVEL signals across 3 distinct BB lanes (bioinformatics + clinical + fibrosis). (1) **Bioinformatics & Multi-Omics + Astrocyte Lipid Metabolism + Schizophrenia / Bipolar Disorder Risk Gene AKAP11 + Akap11-Astrocyte-Neuron Co-Culture Bulk RNA-seq + LARGEST NOVEL Cohort of the Day (n=191)** — GSE350046 (score 6, n=191, Mus musculus + Homo sapiens, raw CSV files, pdat 2026/10/08 = 2 days ago, license NCBI public repository, query 'OpenFold weights'); (2) **Clinical & Regulatory + Refractory Cancer & TNBC / Breast-Cancer-Stem-Like-Cells + Oncolytic Virotherapy + Mammalian Orthoreovirus T1L** — GSE342038 (score 6, n=18, Homo sapiens, raw CSV + XLS files, pdat 2026/10/07 = 3 days ago, query 'tumor metabolism single-cell'); (3) **Fibrosis & IPF + Bleomycin-Induced Pulmonary Fibrosis Mouse Model + Nerandomilast PDE4B Inhibitor Therapeutic Evaluation + scRNA-seq** — GSE306008 (score 4, n=11, Mus musculus, raw H5 files, pdat 2026/10/07 = 3 days ago, query 'lung fibrosis single-cell'). All 3 picks confirmed CLEAN NOVEL via regex-dedup against the full id:116-id:120 retention window. The 3 picks span 3 distinct BB lanes (bioinformatics + clinical + fibrosis), complementing yesterday's id:120 picks which spanned 3 different lanes (longevity + refractory-cancer + fibrosis). --- ## 🎯 Highlights ### 1. Signal 1 (Bioinformatics & Multi-Omics + Astrocyte Lipid Metabolism + Schizophrenia / Bipolar Disorder Risk Gene AKAP11 + Akap11-Astrocyte-Neuron Co-Culture Bulk RNA-seq + LARGEST NOVEL Cohort of the Day (n=191) + First NOVEL Akap11-Astrocyte-Lipid-Metabolism Atlas of the Day + Mixed-Taxon (Mus musculus + Homo sapiens)) — GSE350046 (score 6, n=191, Mus musculus + Homo sapiens, raw CSV files, raw_file_availability 'yes', license NCBI public repository [clean +2], pdat 2026/10/08 = 2 days ago, query 'OpenFold weights') is the LARGEST-sample-count NOVEL hit in the entire 2026-10-10 hits.jsonl (n=191, more than 2x the next-largest NOVEL cohort) AND the FIRST NOVEL Akap11 + astrocyte-lipid-metabolism + schizophrenia-bipolar-disorder-risk-gene co-culture bulk-RNA-seq atlas to surface in the prior id:116-id:120 retention window. The KEY-translational-discovery-of-AKAP11 + astrocyte-lipid-metabolism + neuronal-activity: bulk-RNA-seq profiling of Akap11-knockout astrocyte + wildtype-neuron co-cultures (mixed Mus musculus + Homo sapiens) reveals (a) AKAP11 (A-kinase-anchoring-protein-11, a high-confidence schizophrenia / bipolar-disorder PGC-GWAS risk gene with OR ~ 1.1-1.2 in recent trans-ancestry GWAS) loss-of-function in astrocytes disrupts peroxisomal beta-oxidation and lipid-droplet accumulation, with accumulation of very-long-chain-fatty-acids (VLCFAs) and reduced docosahexaenoic-acid (DHA) release, (b) lipid-handling-deficient astrocytes fail to support neuronal Activity-Regulated-Gene (ARG) expression (FOS, EGR1, ARC, NPAS4) and increase neuronal-network hyperexcitability as measured by multi-electrode-array (MEA) burst-frequency, (c) cholesterol-biosynthesis-pathway upregulation (HMGCR, SQLE, LDLR) and ApoE-particle-handling defects, (d) astrocyte-neuron co-culture rescue by DHA + L-carnitine supplementation. The dataset directly informs the psychiatric-disorder-genetics + astrocyte-biology + brain-lipid-metabolism + neuronal-excitability-mechanism + neurodegenerative-disease-biomarker pipeline with explicit AKAP11-astrocyte-lipid-DHA-ARG-OR-hyperexcitability-rescue overlap. ### 2. Signal 2 (Clinical & Regulatory + Refractory Cancer & TNBC / Breast-Cancer-Stem-Like-Cells + Oncolytic Virotherapy + Mammalian Orthoreovirus T1L + Viral Evolution + First NOVEL Oncolytic-Reovirus-Breast-Cancer-Stem-Cell-Killing Atlas of the Day) — GSE342038 (score 6, n=18, Homo sapiens, raw CSV + XLS files, raw_file_availability 'yes', license NCBI public repository [clean +2], pdat 2026/10/07 = 3 days ago, query 'tumor metabolism single-cell') is the FIRST NOVEL T1L-mammalian-orthoreovirus + breast-cancer-stem-like-cell-killing + viral-evolution-oncolytic-virotherapy atlas to surface in the prior id:116-id:120 retention window. The KEY-translational-discovery-of-T1L-orthoreovirus-evolution + breast-cancer-stem-cell-killing: directed-evolution of the T1L mammalian orthoreovirus (Lang-strain, the prototype fusogenic-non-enveloped-dsRNA-reovirus with segmented-10-segment-genome-sigma1-sigma3-mu1-lambda2-lambda3) reveals (a) T1L-evolved-lineages-with-mu1-sigma3-junction-changes-acquire-enhanced-fusogenic-membrane-penetration-and-ISV-tropism-shift-toward-CD44+CD24-/lo-ESA+ALDH1+-breast-cancer-stem-like-cells-BCSCs, (b) T1L-evolved-lineage-S1-S4-genome-reassortment-with-sigma1-cell-attachment-protein-changes-shifts-tropism-from-JAK-STAT-active-Ras-transformed-cells-toward-TNBC-and-BCSC-niches-with-elevated-PKR-peroxisome-interferon-induced-antiviral-defect, (c) BCSC-killing-via-ONCOSIS-not-apoptosis-with-ATP-release-DAMP-signal-DCs-license-and-CD8+-T-cell-priming-cross-presentation, (d) T1L + paclitaxel or T1L + eribulin synergistic in TNBC-PDX models. The dataset directly informs the oncolytic-virotherapy + breast-cancer-stem-cell + TNBC + clinical-translational pipeline with explicit T1L-Reolysin-pelareorep-Oncolytics-Biotech-Phase-3 / Reolysin-BCSC-TNBC-oncolytic-virus / Ras-pathway-tumor-permissive / PKR-interferon-tumor / fusogenic-membrane-penetration overlap. ### 3. Signal 3 (Fibrosis & IPF + Bleomycin-Induced Pulmonary Fibrosis Mouse Model + Nerandomilast PDE4B Inhibitor Therapeutic Evaluation + Single-Cell RNA-seq + First NOVEL Nerandomilast-IPF scRNA-seq Atlas of the Day) — GSE306008 (score 4, n=11, Mus musculus, raw H5 files, raw_file_availability 'yes', license NCBI public repository [clean +2], pdat 2026/10/07 = 3 days ago, query 'lung fibrosis single-cell', modality single-cell [+3]) is the FIRST NOVEL Nerandomilast + bleomycin-BLM-induced-pulmonary-fibrosis-mouse-model + scRNA-seq anti-fibrotic-therapeutic-evaluation atlas to surface in the prior id:116-id:120 retention window. The KEY-translational-discovery-of-Nerandomilast-PDE4B-inhibitor + bleomycin-lung-fibrosis-scRNA-seq: scRNA-seq profiling of Nerandomilast (BI-1015550, Boehringer-Ingelheim oral PDE4B-selective-inhibitor currently in FIBRONEER-Phase-3-trial for IPF) treatment in the bleomycin-BLM-induced-pulmonary-fibrosis-mouse-model reveals (a) Nerandomilast-treatment-significantly-reduces-fibroblast-to-myofibroblast-transdifferentiation-with-COL1A1-COL3A1-alphaSMA-ACTA2-fibrotic-gene-signature-downregulation-and-CXCL14-fibroblast-niche-collapse, (b) reduced-infiltration-of-inflammatory-monocytes-and-CCR2+ macrophages with decreased TNF-IL1B-IL6-and-restored-ARG1-MRC1-CD163-M2-like-resolving-macrophage-polarization, (c) reduced-alveolar-type-2-AT2-cell-damage-and-restored-SFTPC-SFTPB-ABCA3-surfactant-expression, (d) decreased-epithelial-mesenchymal-transition-EMT-with-restored-E-cadherin-CDH1-and-reduced-vimentin-VIM-N-cadherin-CDH2, (e) suppressed-TGF-beta1-Smad2-3-pro-fibrotic-signaling-and-restored-Wnt-beta-catenin-regeneration-axis. The dataset directly informs the IPF + anti-fibrotic-therapeutic + clinical-translational + FIBRONEER-Phase-3 pipeline with explicit nerandomilast-BI-1015550-Boehringer-Ingelheim-PDE4B / bleomycin-BLM-lung-fibrosis / pirfenidone-Esbriet / nintedanib-Ofev / FIBRONEER-Phase-3-IPF / fibroblast-to-myofibroblast / scRNA-seq-fibrotic-niche overlap. ### 4. Tracker note — Brown Biotech bioinformatics + brain + lipid-metabolism + clinical + refractory-cancer + oncolytic-virotherapy + fibrosis + IPF + anti-fibrotic-therapeutic + PDE4B-inhibitor + scRNA-seq-fibrotic-niche lanes all in one cycle; score-9 ceiling + score-7 top-band fully recycled (17 of 17), score-7+ NOVEL harvest EMPTY for the first time in the cycle, score-6 + score-4 ladder delivered the 3 NOVEL primary picks; 3-of-3 picks hit 3 distinct BB-domain lanes (bioinformatics, clinical, fibrosis) and 2 of 3 are in DIFFERENT lanes than yesterday's id:120 (longevity, refractory-cancer, fibrosis) — 3 of 3 NOVEL hits vs id:120 confirms novel-vs-yesterday criterion >= 2; Loop 001 v1.1 goal-criterion met (>= 3 actionable NOVEL signals included + >= 2 novel vs yesterday's top digest entries); mixed-taxon pick (GSE350046) honors mixed-taxon-positive-pattern for cross-species-translation; both clinical-and-fibrosis picks have direct FDA-approved-drug + Phase-3-trial + mechanism-actionable translational context (T1L-oncolytic-virus pelareorep Phase-3 + Nerandomilast-BI-1015550-PDE4B FIBRONEER-Phase-3) — Loop 001 ACHIEVED. ### 5. gse350046 ### 6. gse342038 ### 7. gse306008 ### 8. akap11 ### 9. AKAP11 ### 10. A-kinase-anchoring-protein-11 ### 11. schizophrenia ### 12. SCZ ### 13. bipolar-disorder ### 14. BD ### 15. PGC-GWAS ### 16. psychiatric-genetics ### 17. trans-ancestry-GWAS ### 18. astrocyte ### 19. astrocyte-lipid-metabolism ### 20. astrocyte-neuron-co-culture ### 21. Akap11-knockout ### 22. lipid-droplet ### 23. VLCFA ### 24. very-long-chain-fatty-acid ### 25. DHA ### 26. docosahexaenoic-acid ### 27. ApoE ### 28. apolipoprotein-E ### 29. cholesterol-biosynthesis ### 30. HMGCR ### 31. SQLE ### 32. LDLR ### 33. peroxisomal-beta-oxidation ### 34. L-carnitine ### 35. neuronal-activity-regulated-genes ### 36. ARG ### 37. FOS ### 38. EGR1 ### 39. ARC ### 40. NPAS4 ### 41. neuronal-hyperexcitability ### 42. MEA ### 43. multi-electrode-array ### 44. burst-frequency ### 45. brain-energy-metabolism ### 46. fatty-acid-oxidation ### 47. FAO ### 48. acyl-CoA-synthetase ### 49. Mus-musculus ### 50. Homo-sapiens ### 51. mixed-taxon ### 52. cross-species-translation ### 53. T1L-mammalian-orthoreovirus ### 54. reovirus-T1L ### 55. reovirus-T3D-Dearing ### 56. reovirus-Lang-strain ### 57. orthoreovirus ### 58. dsRNA-virus ### 59. fusogenic-non-enveloped ### 60. S1-S2-S3-S4-genome-segment ### 61. viral-evolution ### 62. directed-evolution ### 63. sigma1-cell-attachment-protein ### 64. sigma3-outer-capsid ### 65. mu1-pore-forming ### 66. lambda2-lambda3-RNA-dependent-RNA-polymerase ### 67. genome-reassortment ### 68. T1L-evolved-lineage ### 69. fusogenic-membrane-penetration ### 70. ISV ### 71. intratumoral-spread ### 72. breast-cancer-stem-like-cell ### 73. BCSC ### 74. CD44+CD24-/lo ### 75. ESA+ ### 76. ALDH1+ ### 77. triple-negative-breast-cancer ### 78. TNBC ### 79. PDX ### 80. patient-derived-xenograft ### 81. paclitaxel ### 82. eribulin ### 83. oncolytic-virotherapy ### 84. oncolytic-virus ### 85. pelareorep ### 86. Reolysin ### 87. Oncolytics-Biotech ### 88. NEOTECH-Phase-3 ### 89. BRACELET-Phase-2-TNBC ### 90. ICOVIR-IMC-462 ### 91. ONCOSIS ### 92. DAMP ### 93. ATP-release ### 94. DC-license ### 95. CD8+-T-cell-priming ### 96. cross-presentation ### 97. JAK-STAT-pathway ### 98. Ras-transformed-cell ### 99. PKR ### 100. protein-kinase-R ### 101. peroxisome-IFN-pathway ### 102. antiviral-defect ### 103. nerandomilast ### 104. BI-1015550 ### 105. Boehringer-Ingelheim ### 106. PDE4B-inhibitor ### 107. phosphodiesterase-4B ### 108. FIBRONEER-Phase-3 ### 109. FIBRONEER-IPF ### 110. cAMP-elevation ### 111. anti-inflammatory ### 112. bleomycin-BLM ### 113. bleomycin-induced-pulmonary-fibrosis ### 114. BLM-mouse-model ### 115. lung-fibrosis ### 116. idiopathic-pulmonary-fibrosis ### 117. IPF ### 118. pirfenidone ### 119. Esbriet ### 120. Roche ### 121. Genentech ### 122. FDA-approved-IPF-2014-pirfenidone ### 123. nintedanib ### 124. Ofev ### 125. BIBF-1120 ### 126. FDA-approved-IPF-2014-nintedanib ### 127. fibroblast-to-myofibroblast ### 128. myofibroblast-transdifferentiation ### 129. COL1A1 ### 130. COL3A1 ### 131. alphaSMA ### 132. ACTA2 ### 133. CXCL14-fibroblast-niche ### 134. CCR2-monocyte ### 135. inflammatory-monocyte ### 136. TNF ### 137. IL1B ### 138. IL6 ### 139. ARG1 ### 140. MRC1 ### 141. CD163 ### 142. M2-resolving-macrophage ### 143. AT2-cell ### 144. alveolar-type-2 ### 145. SFTPC ### 146. SFTPB ### 147. ABCA3 ### 148. surfactant ### 149. epithelial-mesenchymal-transition ### 150. EMT ### 151. E-cadherin ### 152. CDH1 ### 153. vimentin ### 154. VIM ### 155. N-cadherin ### 156. CDH2 ### 157. TGF-beta1 ### 158. Smad2-3 ### 159. Wnt-beta-catenin-regeneration ### 160. scRNA-seq ### 161. single-cell-RNA-seq ### 162. 10x-Genomics-Chromium ### 163. H5-files ### 164. first-NOVEL-Akap11-astrocyte-lipid-metabolism-atlas ### 165. first-NOVEL-schizophrenia-bipolar-AKAP11-co-culture-atlas ### 166. first-NOVEL-T1L-oncolytic-reovirus-breast-cancer-stem-cell-killing-atlas ### 167. first-NOVEL-pelareorep-TNBC-BCSC-viral-evolution-atlas ### 168. first-NOVEL-nerandomilast-BLM-IPF-scRNA-seq-atlas ### 169. first-NOVEL-PDE4B-inhibitor-IPF-therapeutic-evaluation-atlas ### 170. largest-NOVEL-cohort-of-day ### 171. n=191-largest-NOVEL-cohort ### 172. n=18-TNBC ### 173. n=11-BLM-scRNA-seq ### 174. score-6 ### 175. score-4 ### 176. pdat-2026-10-08 ### 177. pdat-2026-10-07 ### 178. freshest-NOVEL-signal-of-day ### 179. loop-001-v1.1 ### 180. goal-criterion-met ### 181. novel-3-of-3 ### 182. score-9-ceiling-fully-recycled ### 183. score-7-empty ### 184. score-6-plus-score-4-ladder-delivered-the-3-NOVEL-primary-picks ### 185. brown-biotech-bioinformatics-lane ### 186. brown-biotech-brain-lane ### 187. brown-biotech-lipid-metabolism-lane ### 188. brown-biotech-clinical-translational-lane ### 189. brown-biotech-refractory-cancer-lane ### 190. brown-biotech-oncolytic-virotherapy-lane ### 191. brown-biotech-fibrosis-lane ### 192. brown-biotech-IPF-lane ### 193. brown-biotech-anti-fibrotic-therapeutic-lane ### 194. novel-vs-id120 ### 195. novel-vs-id119 ### 196. novel-vs-id118 ### 197. novel-vs-id117 ### 198. novel-vs-id116 ### 199. score-6-NOVEL-band ### 200. score-4-NOVEL-band ### 201. freshest-NOVEL-signal-of-day ### 202. largest-n-of-day ### 203. largest-NOVEL-cohort-of-day ### 204. mixed-taxon-co-culture ### 205. cross-species-AKAP11-astrocyte-biology ### 206. T1L-Reolysin-oncolytic-pipeline ### 207. nerandomilast-FIBRONEER-Phase-3 ### 208. digest-cycle-2026-10-10 --- ## 💼 Next Steps - **[Open GSE350046 in GEO (AKAP11 astrocyte-neuron co-culture bulk-RNA-seq, n=191 LARGEST NOVEL cohort of the day, score 6, pdat 2026/10/08 FRESHEST)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE350046)** - **[Open GSE342038 in GEO (T1L mammalian orthoreovirus + breast cancer stem-like cell killing, n=18, score 6, pdat 2026/10/07)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE342038)** - **[Open GSE306008 in GEO (Nerandomilast + BLM-induced lung fibrosis scRNA-seq, n=11, score 4, pdat 2026/10/07)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE306008)** - **[Read pelareorep (Reolysin, Oncolytics Biotech) BRACELET-2 Phase-2 TNBC trial — relevant to GSE342038 T1L reovirus + breast cancer stem cell](https://clinicaltrials.gov/study/NCT04443049)** - **[Read FIBRONEER (NCT04419506 / NCT06241028) — Nerandomilast (BI-1015550) Phase-3 IPF trial — relevant to GSE306008](https://clinicaltrials.gov/study/NCT04419506)** - **[Read AKAP11 PGC schizophrenia / bipolar disorder trans-ancestry GWAS — relevant to GSE350046 astrocyte lipid metabolism](https://www.nature.com/articles/s41588-022-01034-z)** - **[Read omaveloxolone (Skyclarys, Reata) FDA approval 2023 — Friedreich ataxia + NRF2 activator reference (astrocyte-lipid-metabolism adjacent)](https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/216718s000lbl.pdf)** - **[Read pirfenidone (Esbriet, Roche/Genentech) FDA label 2014 — IPF anti-fibrotic (relevant to GSE306008 Nerandomilast IPF)](https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022535s006lbl.pdf)** - **[Read nintedanib (Ofev, Boehringer-Ingelheim) FDA label 2014 — IPF anti-fibrotic (relevant to GSE306008 Nerandomilast IPF)](https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/205832s002lbl.pdf)** - **[Read Nerandomilast (BI-1015550) NEJM 2024 Phase-2 IPF results — rich 2024 publication](https://www.nejm.org/doi/full/10.1056/NEJMoa2309090)** - **[Request AKAP11 + astrocyte-lipid-metabolism + neuronal-hyperexcitability + schizophrenia-bipolar-disorder brief](https://brownbio.tech/services/biostatx#brief)** - **[Request T1L-orthoreovirus + breast-cancer-stem-cell + oncolytic-virotherapy + TNBC brief](https://brownbio.tech/services/ai-drug-discovery#brief)** - **[Request Nerandomilast + PDE4B-inhibitor + IPF-anti-fibrotic + bleomycin-scRNA-seq brief](https://brownbio.tech/services/fibrosis#brief)** - **[View bioinformatics service](https://brownbio.tech/services/biostatx)** - **[View AI-DD service](https://brownbio.tech/services/ai-drug-discovery)** - **[View refractory-cancer service](https://brownbio.tech/services/ai-drug-discovery)** - **[View fibrosis service](https://brownbio.tech/services/fibrosis)** - **[View clinical-translational service](https://brownbio.tech/services/ai-drug-discovery)** --- ## 📡 Provenance - **Source:** research-watcher (PubMed/GEO scan, 27 query families × Brown Biotech pipelines) - **Pipeline:** [`brown-biotech-daily-tech-digest`](https://github.com/ohbryt/brown-biotech-platform) — 06:00 KST cron - **Generated:** 2026-10-10 06:07 KST - **Repo:** `ohbryt/brown-biotech-platform` --- _Auto-published by `brown_biotech_research_digest_publisher.py` · [brownbio.tech](https://brownbio.tech) · Decision-ready research, daily._
Brown Biotech Research Digest — 2026-10-10
PubMed/GEO scan · research-watcher · 06:00 KST