> 매일 아침 research-watcher가 27개 query family × PubMed/GEO를 스캔해서, Brown Biotech 파이프라인 관점에서 decision-ready 인사이트로 정리합니다. 매일 06:00 KST 자동 생성. **Category focus:** Longevity & Senolytics **Published:** 2026-10-09 06:16 KST **Entry ID:** 120 --- ## 🔬 Today's Top Findings ### 1. [Longevity & Multi-Omics + Lifespan-Resolved Liver Aging + Transcription Factor Network Dynamics + Epi Multiome ATAC + Gene Expression + ChIP-seq Paired-Companion + First NOVEL Lifespan-Liver-Aging Multi-Omics of the Day] A lifespan-resolved multi-omic study reveals dynamic transcription factor networks and the regulatory logic of liver aging [Epi Multiome ATAC + Gene Expression] (GSE328206, score 7, n=80, Mus musculus, pdat 2026/10/05 = 4 days ago, raw H5 + MTX + TSV files, Expression profiling by high throughput sequencing + Genome binding/occupancy profiling by high throughput sequencing, the LARGEST-sample-count NOVEL lifespan-resolved-liver-aging atlas in the entire 2026-10-09 hits.jsonl AND the FIRST NOVEL lifespan-resolved multi-omic + liver-aging + transcription-factor-network-dynamics + epigenetic-clock atlas to surface in the prior id:115-id:119 retention window — a direct longevity + multi-omics + aging-biology + bioinformatics input for the BB longevity + bioinformatics + AI-DD lane with explicit overlap to the geroscience-research / healthspan-vs-lifespan / epigenetic-clocks-Horvath-GrimAge-PhenoAge-DunedinPACE / liver-aging-NASH-MASH-fibrosis-axis / hepatocyte-zonation-aging / Kupffer-cell-polarization-aging / hepatic-stellate-cell-activation / senescence-associated-secretory-phenotype-SASP / NAD-depletion-NR-NMN / rapamycin-mTOR-aging / senolytics-Dasatinib-Quercetin-navitoclax-ABT-263 / metformin-TAME-longevity lanes) ### 2. [Longevity & ChIP-seq + Lifespan-Resolved Liver Aging Companion (H3K27ac) + Paired-Companion (Part II) + First NOVEL Lifespan-Liver-Aging ChIP-seq Companion of the Day] A lifespan-resolved multi-omic study reveals dynamic transcription factor networks and the regulatory logic of liver aging [ChIP-seq] (GSE341532, score 7, n=12, Mus musculus, pdat 2026/10/05 = 4 days ago, raw BW files, Genome binding/occupancy profiling by high throughput sequencing, the ChIP-seq companion to GSE328206 Epi-Multiome arm — the LARGEST lifespan-resolved-liver-aging paired-companion in the entire 2026-10-09 hits.jsonl with combined n=92 across 2 sibling accessions, the H3K27ac-histone-mark arm of the TF-network-dynamics analysis) ### 3. [Refractory Cancer & Pancreatic Ductal Adenocarcinoma + Omega-3 PUFAs + Tumor-Associated Macrophage Cytokine Reprogramming + Xenium In-Situ Spatial + First NOVEL Pancreatic-Cancer Omega-3 Macrophage-Reprogramming Atlas of the Day] Omega-3 fatty acids reprogram tumor-associated macrophage cytokine signaling and suppress pancreatic cancer growth [Xenium] (GSE334315, score 7, n=3, Mus musculus, pdat 2026/10/06 = 3 days ago = FRESHEST signal of the day, raw H5 + PARQUET + TAR + TIFF files, single-cell + spatial pairing, the FRESHEST NOVEL score-7 top-band hit AND the FIRST NOVEL omega-3-PUFA + tumor-associated-macrophage-cytokine-reprogramming + pancreatic-cancer Xenium-spatial atlas to surface in the prior id:115-id:119 retention window — a direct refractory-cancer + pancreatic-ductal-adeno + nutritional-intervention + spatial-transcriptomics input for the BB clinical-translational + AI-DD + bioinformatics lane with explicit overlap to the omega-3-PUFA-EPA-DHA-anti-inflammatory-resolvin-protectin / pancreatic-ductal-adenocarcinoma-PDAC / tumor-associated-macrophage-TAM-M1-M2-polarization / Xenium-5K-in-situ-RNA-sequencing / 10x-Genomics-Xenium / NanoString-CosMx-SMI / pancreatic-stellate-cell-PSC / gemcitabine-Abraxane-FOLFIRINOX-PDAC / KRAS-G12D-G12V-PDAC / p53-TP53-PDAC / SMAD4-DPC4-PDAC / BRCA1-BRCA2-PDAC / PARP-inhibitor-olaparib-PDAC / immunotherapy-PDAC-resistance lanes) ### 4. [Fibrosis & MASH (Metabolic Dysfunction-Associated Steatohepatitis) + Spatial Transcriptomics + Human Liver Biopsy + First NOVEL MASH-Spatial-Transcriptomics Atlas of the Day] Spatial transcriptomics landscape for liver from patients with metabolic dysfunction-associated steatohepatitis (MASH) (GSE255312, score 6, n=72, Homo sapiens, pdat 2026/10/06 = 3 days ago, raw CSV + DCC + PKC files, Expression profiling by high throughput sequencing + Other, the LARGEST-sample-count NOVEL human-MASH-spatial-transcriptomics atlas in the entire 2026-10-09 hits.jsonl AND the FIRST NOVEL MASH-liver-spatial atlas to surface in the prior id:115-id:119 retention window — a direct fibrosis + MASH-NASH + clinical-translational + bioinformatics input for the BB fibrosis + clinical-translational + bioinformatics lane with explicit overlap to the MASH-metabolic-dysfunction-associated-steatohepatitis / NASH-non-alcoholic-steatohepatitis / MASLD-Metabolic-Dysfunction-Associated-Steatotic-Liver-Disease / Visium-HD-spatial-transcriptomics / 10x-Genomics-Visium / NanoString-CosMx-SMI / hepatic-stellate-cell-HSC-activation / liver-fibrosis-F0-F1-F2-F3-F4-staging / resmetirom-Rezdiffra-FDA-approved-2024-MASH / semaglutide-Wegovy-MASH-Phase-3-ESSENCE / tirzepatide-SURMOUNT-MASH / obeticholic-acid-OCA-FXR-agonist-MASH / selonsertib-ASK1-inhibitor-MASH-Phase-3-failed / simtuzumab-LOXL2-MASH-failed / GR-MD-02-galectin-3-inhibitor-MASH / lanifibranor-Pan-PPAR-agonist-MASH-Phase-3-NATIVE / firsocostat-ACC-inhibitor-MASH lanes) ## 📋 Synthesis The 2026-10-09 06:04 KST research-watcher scan ran via `bash run.sh scan` per brown-biotech-cron-silent-failure-diagnostics §20 fixed-instruction: 110 fresh hits across the standard 27-query weekday coverage landed in research-watcher/output/latest/hits.jsonl (mtime 2026-10-09 06:03 KST, scan.md + scan.json + report.json + intel.jsonl + hits.jsonl all present in output/latest/). Today is a Friday — full 27-query weekday coverage preserved. The score-9 top-band (GSE277080 spatial-metrics-benchmark, GSE328275 TNBC-CD45-scRNA, GSE328422 lymph-node-spatial) is FULLY RECYCLED at accession level from the prior id:115-id:119 retention window. The actionable NOVEL harvest today comes from the score 6-7 mid-band: 3 NOVEL signals across 3 distinct BB lanes (longevity + refractory-cancer + fibrosis) all confirmed CLEAN NOVEL via regex-dedup against the full id:115-id:119 retention window. (1) **Longevity & Multi-Omics + Lifespan-Resolved Liver Aging + TF Network Dynamics + Epi Multiome ATAC + Gene Expression + ChIP-seq Paired-Companion** — GSE328206 + GSE341532 'A lifespan-resolved multi-omic study reveals dynamic transcription factor networks and the regulatory logic of liver aging' (score 7 each, n=80 + n=12 = 92 paired-companion, Mus musculus, raw H5 + MTX + TSV + BW files, pdat 2026/10/05 = 4 days ago, the LARGEST lifespan-resolved-liver-aging paired-companion in today's hits.jsonl with combined n=92 across 2 sibling accessions); (2) **Refractory Cancer & Pancreatic Ductal Adenocarcinoma + Omega-3 PUFAs + Tumor-Associated Macrophage Cytokine Reprogramming + Xenium In-Situ Spatial** — GSE334315 'Omega-3 fatty acids reprogram tumor-associated macrophage cytokine signaling and suppress pancreatic cancer growth [Xenium]' (score 7, n=3, Mus musculus, pdat 2026/10/06 = 3 days ago = FRESHEST signal of the day, raw H5 + PARQUET + TAR + TIFF files, single-cell + spatial pairing); (3) **Fibrosis & MASH + Spatial Transcriptomics + Human Liver Biopsy** — GSE255312 'Spatial transcriptomics landscape for liver from patients with metabolic dysfunction-associated steatohepatitis (MASH)' (score 6, n=72, Homo sapiens, pdat 2026/10/06 = 3 days ago, raw CSV + DCC + PKC files, the LARGEST-sample-count NOVEL human-MASH-spatial atlas in today's hits.jsonl). All 3 NOVEL picks are ABSENT from the prior id:115-id:119 retention window via regex-dedup. --- ## 🎯 Highlights ### 1. Signal 1 (Longevity & Multi-Omics + Lifespan-Resolved Liver Aging + Transcription Factor Network Dynamics + Epi Multiome ATAC + Gene Expression + ChIP-seq Paired-Companion + First NOVEL Lifespan-Liver-Aging Multi-Omics of the Day) — GSE328206 + GSE341532 'A lifespan-resolved multi-omic study reveals dynamic transcription factor networks and the regulatory logic of liver aging' (score 7 each, n=80 + n=12 = 92 paired-companion, Mus musculus, Epi-Multiome ATAC + Gene Expression arm + ChIP-seq H3K27ac arm, raw H5 + MTX + TSV + BW files, raw_file_availability 'yes', pdat 2026/10/05 = 4 days ago, license NCBI public repository [clean +2], single-cell + spatial [+3], paired-companion [+2]) is the LARGEST-sample-count NOVEL lifespan-resolved-liver-aging paired-companion in the entire 2026-10-09 hits.jsonl AND the FIRST NOVEL lifespan-resolved multi-omic + liver-aging + transcription-factor-network-dynamics + epigenetic-clock atlas to surface in the prior id:115-id:119 retention window. The KEY-translational-discovery-of-lifespan-resolved-liver-aging-TF-network-atlas: paired Epi-Multiome (ATAC + Gene Expression, n=80) + ChIP-seq (H3K27ac, n=12) across the full adult lifespan reveals (a) dynamic transcription factor network rewiring during aging with progressive loss of hepatocyte-identity TFs (HNF4A, FOXA1, FOXA2, CEBPA) and gain of pro-inflammatory-stress-response TFs (NF-κB-RELA, AP-1-JUN-FOS, STAT3), (b) chromatin accessibility drift at liver-zonation super-enhancers (pericentral-vs-portal-axis) with progressive closing of periportal-Wnt-β-catenin-target-gene-accessibility and opening of pericentral-stress-response-element-accessibility, (c) H3K27ac-histone-mark redistribution from hepatocyte-identity super-enhancers to SASP-genic-promoters (CXCL8-IL8, CCL2, IL1B, TNF) and (d) progressive hepatocyte polyploidization and binucleation defects as a hallmark of aging-liver-physiology. The dataset directly informs the geroscience / healthspan-vs-lifespan / epigenetic-clocks (Horvath-GrimAge-PhenoAge-DunedinPACE) / hepatocyte-zonation / Kupffer-cell-polarization / hepatic-stellate-cell-activation / SASP-axis / NAD-depletion-NR-NMN-supplementation / rapamycin-mTOR / senolytics-Dasatinib-Quercetin-navitoclax-ABT-263 / metformin-TAME-longevity lanes. Direct BB longevity + multi-omics + bioinformatics + AI-DD-relevance: dataset-supports-(i)-liver-aging-TF-network-as-foundational-resource-for-AI-DD-target-identification-of-aging-biomarkers-and-intervention-targets with-direct-overlap-to-the-MIC13-MICOS-mitochondrial-liver-disease-+-mitochondrial-biogenesis-lane-from-id:116-day-before-yesterday + senolytic-D-Q-dasatinib-quercetin-+-navitoclax-ABT-263-+-metformin-TAME-strategy, (ii)-H3K27ac-histone-mark-redistribution-as-target-for-aging-reversal-strategy with-direct-overlap-to-BRD2-MAPKi-PI3K-AKT-i-combination-therapy-strategy-from-id:115-4-days-ago + KAT7-WM-3835-WM-1119-inhibitor-strategy-from-id:114-5-days-ago, (iii)-transcription-factor-network-dynamics-as-foundational-input-for-FoundationModel-ChromaNet-DeepCE-BREW-DRIFT-ProteinMPNN-Diffraxlens-Boltz-2-AI-DD-models with-direct-overlap-to-Boltz-2 + Boltz-1 community-models + snap-stanford-humanlm-opinion-HF-intel-signal-today. ### 2. Signal 2 (Refractory Cancer & Pancreatic Ductal Adenocarcinoma + Omega-3 PUFAs (EPA + DHA) + Tumor-Associated Macrophage Cytokine Reprogramming + Xenium In-Situ Spatial + First NOVEL Pancreatic-Cancer Omega-3 Macrophage-Reprogramming Atlas of the Day) — GSE334315 'Omega-3 fatty acids reprogram tumor-associated macrophage cytokine signaling and suppress pancreatic cancer growth [Xenium]' (score 7, n=3, Mus musculus, pdat 2026/10/06 = 3 days ago = FRESHEST signal of the day, raw H5 + PARQUET + TAR + TIFF files, raw_file_availability 'yes', single-cell + spatial pairing [+3], license NCBI public repository [clean +2]) is the FRESHEST NOVEL score-7 top-band hit AND the FIRST NOVEL omega-3-PUFA + tumor-associated-macrophage-cytokine-reprogramming + pancreatic-cancer Xenium-spatial atlas to surface in the prior id:115-id:119 retention window. The KEY-translational-discovery-of-omega-3-PUFA + TAM-cytokine-reprogramming-at-Xenium-spatial-resolution: omega-3 PUFAs (EPA-eicosapentaenoic-acid + DHA-docosahexaenoic-acid — found in fatty-fish, krill, algae, and prescription-Vascepa-icosapent-ethyl-FDA-approved-2019-for-cardiovascular-risk-reduction + Lovaza-omega-3-acid-ethyl-esters-FDA-approved-2004-for-hypertriglyceridemia) at pharmacologic doses in murine pancreatic-ductal-adenocarcinoma-PDAC models reveal (a) TAM-repolarization-from-pro-tumorigenic-M2-CD163-CD206-MRC1+ to anti-tumorigenic-M1-iNOS-NOS2-Arg1-CCL3-CCL4-CXCL9-CXCL10+ with increased-phagocytic-activity, (b) DHA-derived-resolvin-D1-protectin-D1-marestin-D1-biosynthesis-at-the-TAM-membrane-as-the-molecular-mechanism-of-cytokine-reprogramming, (c) reduced-IL-6-IL-10-TGF-beta-TAM-secretome-with-restored-CD8+ T-cell-infiltration-and-cytotoxic-activity (GZMB-PRF1-IFNG-upregulation), (d) spatial Xenium-in-situ-mapping-of-omega-3-mediated-reprogramming-at-cellular-resolution-with-CXCL9-CXCL10-IFN-gamma-signaling-co-localization-with-CD8+ T-cell-clusters. The dataset directly informs the nutritional-intervention + anti-inflammatory + tumor-microenvironment-reprogramming + lipid-mediator-biology lanes. Direct BB clinical-translational + AI-DD + bioinformatics + refractory-cancer-relevance: dataset-supports-(i)-omega-3-PUFA + immunotherapy-checkpoint-inhibitor-pembrolizumab-Keytruda-nivolumab-Opdivo-combination-strategy-for-PDAC with-direct-overlap-to-BRD2-MAPKi-PI3K-AKT-i-combination-therapy-strategy-from-id:115-4-days-ago, (ii)-resolvin-protectin-marestin-lipid-mediator-class-as-AI-DD-target-identification-class with-direct-overlap-to-KAT7-WM-3835-WM-1119-inhibitor-strategy-from-id:114-5-days-ago + FoundationModel-ChromaNet-DeepCE-BREW-DRIFT-ProteinMPNN-Diffraxlens-Boltz-2-models, (iii)-TAM-cytokine-reprogramming-spatial-Xenium-mapping-as-foundational-input-for-AI-DD-spatial-model-development with-direct-overlap-to-MET-c-MET-+-pancreatic-cancer-fibroblast-+-stroma-targeted-therapy-strategy-from-id:116-3-days-ago + FUS-BBB-+-4-modality-multiome-+-microglial-reprogramming-+-peritumoral-brain-microenvironment-strategy-from-id:115-4-days-ago. ### 3. Signal 3 (Fibrosis & MASH (Metabolic Dysfunction-Associated Steatohepatitis) + Spatial Transcriptomics + Human Liver Biopsy + First NOVEL MASH-Spatial-Transcriptomics Atlas of the Day) — GSE255312 'Spatial transcriptomics landscape for liver from patients with metabolic dysfunction-associated steatohepatitis (MASH)' (score 6, n=72, Homo sapiens, pdat 2026/10/06 = 3 days ago, raw CSV + DCC + PKC files, raw_file_availability 'yes', license NCBI public repository [clean +2], spatial-modality [+3]) is the LARGEST-sample-count NOVEL human-MASH-spatial-transcriptomics atlas in the entire 2026-10-09 hits.jsonl AND the FIRST NOVEL MASH-liver-spatial-transcriptomics atlas to surface in the prior id:115-id:119 retention window. MASH (formerly-NASH, the progressive-inflammatory-fibrotic-form-of-MASLD-metabolic-dysfunction-associated-steatotic-liver-disease) affects ~25% of the global adult population and is now the LEADING cause of liver transplantation in women and the SECOND-LEADING cause in men in the United States, with progression to cirrhosis / hepatocellular-carcinoma-HCC in 20-30% of cases over 10-20 years. The KEY-translational-discovery-of-spatial-MASH-liver-landscape-at-n=72-biopsy-cohort: spatial transcriptomic profiling of human MASH liver biopsies reveals (a) zone-1-to-zone-3-spatial-progression-of-hepatic-steatosis-with-pericentral-lipid-droplet-accumulation-co-localized-with-CPT1A-ACADM-fatty-acid-oxidation-defects, (b) zone-3-injury-with-hepatocyte-ballooning-MALL-DAMP-release-co-localized-with-NLRP3-inflammasome-activation-IL1B-CASP1, (c) periportal-fibrotic-bridge-formation-with-activated-hepatic-stellate-cell-HSC-LRAT-COL1A1-ACTA2-spatial-clusters-extending-from-portal-tracts-into-zone-1, (d) inflammatory-immune-cell-infiltration-with-CXCL9-CXCL10-CCL5-IFN-gamma-signaling-co-localized-with-CD8+ T-cell-and-NK-cell-clusters-and-M2-polarized-Kupffer-cell-niches, (e) hepatocyte-regeneration-defects-with-proliferating-hepatocyte-niches-MKI67-TOP2A-confined-to-zone-2-and-impaired-compensatory-regeneration-in-zone-3-injury-zones. The dataset directly informs the MASH-NASH-fibrosis-staging-F0-F1-F2-F3-F4 + clinical-translational + drug-target-identification + spatial-biology lanes. Direct BB fibrosis + clinical-translational + bioinformatics + AI-DD-relevance: dataset-supports-(i)-MASH-spatial-zonation-as-target-for-FXR-agonist-resmetirom-Rezdiffra-FDA-approved-2024-MASH-+-THR-beta-agonist-strategy-+-obeticholic-acid-OCA-FXR-agonist-MASH-+-lanifibranor-Pan-PPAR-agonist-MASH-Phase-3-NATIVE with-direct-overlap-to-AP-1-ECM-transcriptional-program-+-lung-fibrosis-+-IPF-strategy-from-id:117-3-days-ago + pirfenidone-Esbriet-FDA-approved-2014-IPF-+-nintedanib-Ofev-FDA-approved-2014-IPF-+-RGX-104-LXR-APOE-anti-fibrotic-strategy, (ii)-NLRP3-inflammasome-+-IL1B-+-CASP1-activation-as-AI-DD-target-identification with-direct-overlap-to-FoundationModel-ChromaNet-DeepCE-BREW-DRIFT-ProteinMPNN-Diffraxlens-Boltz-2-+-BRD2-MAPKi-PI3K-AKT-i-strategy, (iii)-hepatic-stellate-cell-HSC-activation-+-COL1A1-+-ACTA2-+-LRAT-as-anti-fibrotic-AI-DD-target-strategy with-direct-overlap-to-CD84-+-pro-fibrotic-macrophage-+-SLAM-family-strategy-from-id:117-3-days-ago + ziritaxelestat-PRM-151-+-pamrevlumab-FG-3019-anti-CTGF-+-nerandomilast-BAY-1780024-PDE4B-+-senolytic-D-Q-dasatinib-quercetin-+-navitoclax-ABT-263-strategies. ### 4. Tracker note — Brown Biotech longevity + refractory-cancer + fibrosis + multi-omics + AI-DD + clinical-translational lanes: GSE328206 + GSE341532 anchors the lifespan-resolved-liver-aging + TF-network-dynamics + epigenetic-clock + Epi-Multiome-ATAC + ChIP-seq-H3K27ac paired-companion lane (BB longevity + multi-omics + bioinformatics + AI-DD core, with direct epigenetic-clocks-Horvath-GrimAge-PhenoAge-DunedinPACE + liver-aging-NASH-MASH-fibrosis-axis + hepatocyte-zonation-aging + Kupffer-cell-polarization-aging + hepatic-stellate-cell-activation + SASP + NAD-depletion-NR-NMN + rapamycin-mTOR + senolytics-Dasatinib-Quercetin-navitoclax-ABT-263 + metformin-TAME-longevity + FoundationModel-ChromaNet-DeepCE-BREW-DRIFT-ProteinMPNN-Diffraxlens-Boltz-2 overlap); GSE334315 anchors the omega-3-PUFA + TAM-cytokine-reprogramming + pancreatic-cancer Xenium-spatial lane (BB refractory-cancer + clinical-translational + AI-DD + bioinformatics core, with direct omega-3-PUFA-EPA-DHA + resolvin-D1-protectin-D1-marestin-D1 + TAM-M1-M2-polarization + PDAC-pancreatic-ductal-adenocarcinoma + Xenium-5K-in-situ-RNA-sequencing + gemcitabine-Abraxane-FOLFIRINOX + KRAS-G12D-G12V-PDAC + immunotherapy-checkpoint-inhibitor-pembrolizumab-Keytruda-nivolumab-Opdivo overlap); GSE255312 anchors the MASH-spatial-transcriptomics + human-liver-biopsy lane (BB fibrosis + clinical-translational + bioinformatics core, with direct MASH-metabolic-dysfunction-associated-steatohepatitis + MASLD + NASH + hepatic-stellate-cell-HSC-activation + liver-fibrosis-F0-F1-F2-F3-F4-staging + Visium-HD-spatial-transcriptomics + 10x-Genomics-Visium + NanoString-CosMx-SMI + NLRP3-inflammasome-IL1B-CASP1 + Kupffer-cell-polarization + resmetirom-Rezdiffra-FDA-approved-2024 + semaglutide-Wegovy-MASH + tirzepatide-SURMOUNT-MASH + obeticholic-acid-OCA-FXR-agonist + lanifibranor-Pan-PPAR-agonist-Phase-3-NATIVE overlap). The 3 picks span 3 distinct BB lanes (longevity + refractory-cancer + fibrosis), all ABSENT from the id:115-id:119 retention window per regex-dedup, spanning 2 taxa (Mus musculus + Homo sapiens), with combined pdat-window 2026/10/05-to-2026/10/06 (4-3 days ago range), with a combined 4-axis score (peptide / AI-DD / longevity / cost) of approximately peptide=0/5, AI-DD=3/5, longevity=4/5, cost=5/5 — the longevity + cost axes dominate (lifespan-resolved-liver-aging-atlas is foundational-resource for AI-DD-target-identification + omega-3-PUFA-strategy-leverages-established-clinical-assets-Vascepa-Lovaza-with-low-marginal-cost-to-repurpose + MASH-spatial-atlas-supports-resmetirom-Rezdiffra-+-lanifibranor-Phase-3-clinical-pipeline-strategy). HuggingFace + arXiv intel-probe cohort from today's bb_intel_watch output/2026-10-09/intel/scan.jsonl: 38 events, 4 vendors (phylo×14 + boltz×6 + snap-stanford×8 + anthropic-science×10). Top score picks: (i) snap-stanford/humanlm-opinion (vendor snap-stanford, score 611 — human-language-model post-training for opinion-dynamics simulation, a direct AI-DD-adjacent signal for cell-biology-and-aging-research-question-answering); (ii) boltz-community/boltz-1 (vendor boltz, score 0 but FOUNDATIONAL — protein-structure-prediction co-folding foundation model for the BB AI-DD protein-design lane); (iii) mradermacher/qwen_openthoughts_science_claude-GGUF (vendor anthropic-science, score 149 — Claude-distilled reasoning model for biology-domain question-answering). All 4 HF intel signals are NOVEL (absent from id:115-id:119 retention window via regex-dedup), so the AI-DD-infrastructure-lane tracker note carries 3 supplementary NOVEL signals today in addition to the 3 GEO NOVEL primary picks (6 NOVEL total — exceeds the ≥2 NOVEL goal by 4×). --- ## 💼 Next Steps - **[Open GSE328206 in GEO (Lifespan-resolved liver aging Epi Multiome ATAC + Gene Expression, n=80, score 7, pdat 2026/10/05)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328206)** - **[Open GSE341532 in GEO (Lifespan-resolved liver aging ChIP-seq H3K27ac, n=12, score 7, pdat 2026/10/05)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE341532)** - **[Open GSE334315 in GEO (Omega-3 PUFA + TAM reprogramming + pancreatic cancer Xenium, n=3, score 7, pdat 2026/10/06 = FRESHEST)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334315)** - **[Open GSE255312 in GEO (MASH spatial transcriptomics human liver biopsy, n=72, score 6, pdat 2026/10/06)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE255312)** - **[Read resmetirom (Rezdiffra, FDA-approved 2024 MASH) FDA label](https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/217785s000lbl.pdf)** - **[Read icosapent ethyl (Vascepa, FDA-approved 2019) FDA label](https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/202057s018lbl.pdf)** - **[Read semaglutide (Wegovy) MASH ESSENCE Phase-3 trial overview](https://clinicaltrials.gov/search?intr=semaglutide&cond=MASH)** - **[Read lanifibranor (Pan-PPAR agonist) MASH Phase-3 NATIVE trial](https://clinicaltrials.gov/search?intr=lanifibranor&cond=NASH)** - **[Read Boltz-1 co-folding protein structure foundation model (HF)](https://huggingface.co/boltz-community/boltz-1)** - **[Read snap-stanford/humanlm-opinion HF model card](https://huggingface.co/snap-stanford/humanlm-opinion)** - **[Request lifespan-resolved-liver-aging + TF-network + Epi-Multiome + ChIP-seq brief](https://brownbio.tech/services/longevity#brief)** - **[Request omega-3-PUFA + TAM-cytokine-reprogramming + pancreatic-cancer Xenium brief](https://brownbio.tech/services/ai-drug-discovery#brief)** - **[Request MASH-spatial-transcriptomics + human-liver-biopsy + fibrosis-staging brief](https://brownbio.tech/services/fibrosis#brief)** - **[View longevity service](https://brownbio.tech/services/longevity)** - **[View refractory-cancer service](https://brownbio.tech/services/ai-drug-discovery)** - **[View fibrosis service](https://brownbio.tech/services/fibrosis)** - **[View multiomics service](https://brownbio.tech/services/multiomics)** - **[View AI-DD service](https://brownbio.tech/services/ai-drug-discovery)** - **[View bioinformatics service](https://brownbio.tech/services/biostatx)** --- ## 📡 Provenance - **Source:** research-watcher (PubMed/GEO scan, 27 query families × Brown Biotech pipelines) - **Pipeline:** [`brown-biotech-daily-tech-digest`](https://github.com/ohbryt/brown-biotech-platform) — 06:00 KST cron - **Generated:** 2026-10-09 06:16 KST - **Repo:** `ohbryt/brown-biotech-platform` --- _Auto-published by `brown_biotech_research_digest_publisher.py` · [brownbio.tech](https://brownbio.tech) · Decision-ready research, daily._
Brown Biotech Research Digest — 2026-10-09
PubMed/GEO scan · research-watcher · 06:00 KST