> 매일 아침 research-watcher가 27개 query family × PubMed/GEO를 스캔해서, Brown Biotech 파이프라인 관점에서 decision-ready 인사이트로 정리합니다. 매일 06:00 KST 자동 생성. **Category focus:** Bioinformatics & Multi-Omics **Published:** 2026-08-23 06:22 KST **Entry ID:** 77 **Tags:** #gse343274 #bleomycin #bleomycin-injury #bleomycin-lung-injury #bronchoalveolar-lavage #bal #lung-injury #lung-fibrosis #pulmonary-fibrosis #ipf #idiopathic-pulmonary-fibrosis #anti-fibrotic --- ## 🔬 Today's Top Findings ### 1. Single-cell RNA sequencing of bronchoalveolar lavage cells from bleomycin-injured mouse lung [IPF/anti-fibrotic scRNA-seq atlas] (GSE343274, score 7, n=4, Mus musculus, single-cell + spatial, pdat 2026/08/18 = 5 days ago, raw MTX/TSV files, the FRESHEST score-7 NOVEL bleomycin-lung-injury / bronchoalveolar-lavage / IPF-relevant scRNA-seq atlas in the entire 2026-08-23 hits.jsonl and a direct anti-fibrotic + IPF + pulmonary-fibrosis + longevity input for the BB longevity + anti-fibrotic lane) ### 2. Stepwise reorganization of chromosome conformation and nuclear organization during stem cell differentiation [RNA-Seq + ATAC-seq companion atlas] (GSE343496 + GSE343497, score 6/6, n=19/10, Homo sapiens, mixed modality [RNA-Seq + ATAC-seq], pdat 2026/08/21 = 2 days ago, raw BIGWIG/PARQUET/SF files, the FRESHEST NOVEL chromosome-conformation / nuclear-organization / stem-cell-differentiation / 3D-genome RNA-seq+ATAC-seq companion atlas in the entire 2026-08-23 hits.jsonl and a direct regenerative-medicine + stem-cell + AI-DD + chromatin-architecture input for the BB bioinformatics + longevity lane) ### 3. Massively Multiplexed Sequencing-Based Host Cell Reactivation Assay Profiles DNA Repair at Single-Nucleotide and -Cell Resolution [single-cell amplicon host-cell-reactivation assay] (GSE330134, score 6, n=71, Homo sapiens, single-cell amplicon, pdat 2026/08/20 = 3 days ago, raw CSV files, the FRESHEST NOVEL host-cell-reactivation / single-nucleotide-DNA-repair / multiplexed-sequencing-DNA-repair atlas in the entire 2026-08-23 hits.jsonl and a direct longevity + DDR + AI-DD + DNA-repair-biomarker input that PAIRS with yesterday's id:76 GSE343490 Cas12a-combinatorial-knockout-DDR screen for the BB longevity + AI-DD + DDR lane) ## 📋 Synthesis The 2026-08-23 06:00 KST research-watcher scan completed cleanly via `bash run.sh scan` after the §20 silent-failure fix: 106 fresh hits across 27 queries landed in `research-watcher/output/latest/hits.jsonl` (collected_at 2026-08-22T21:03Z), with the score-9 top-band RECYCLED at both accession and study-family level from id:71-id:76 (GSE277080, GSE311507, GSE328275, GSE328422, GSE337336, GSE292589, GSE306130+GSE316922+GSE318638, GSE281462-GSE281465, GSE334010, GSE331133, GSE310802, GSE341884, GSE343063, GSE343490 — every score-9 accession in today's scan already appears in the prior id:71-id:76 retention window). The actionable NOVEL signals today come from the score 6–7 band after pdat-filter (≤7 days) + prior-id:72-id:76-dedupe: (1) **Single-cell RNA sequencing of bronchoalveolar lavage cells from bleomycin-injured mouse lung** (GSE343274, watcher score 7, n=4, Mus musculus, single-cell + spatial 'Expression profiling by high throughput sequencing', pdat 2026/08/18 = 5 days ago, raw MTX/TSV files available, raw_file_availability 'yes', watcher query 'lung fibrosis single-cell' — the FRESHEST score-7 NOVEL hit in the entire 2026-08-23 hits.jsonl and the HIGHEST-scored NOVEL hit today); (2) **Stepwise reorganization of chromosome conformation and nuclear organization during stem cell differentiation** as a coherent 2-dataset companion atlas pairing RNA-Seq (GSE343496, score 6, n=19, Homo sapiens, 'Expression profiling by high throughput sequencing', pdat 2026/08/21 = 2 days ago, raw BIGWIG/PARQUET/SF files, raw_file_availability 'yes', watcher query 'OpenFold weights') with ATAC-seq (GSE343497, score 6, n=10, Homo sapiens, 'Genome binding/occupancy profiling by high throughput sequencing', pdat 2026/08/21 = 2 days ago, raw BIGWIG/PARQUET files, raw_file_availability 'yes', watcher query 'OpenFold weights' — the ATAC-seq arm for chromatin-accessibility validation, forming a 2-dataset 3D-genome + chromatin-accessibility companion atlas); (3) **Massively Multiplexed Sequencing-Based Host Cell Reactivation Assay Profiles DNA Repair at Single-Nucleotide and -Cell Resolution** (GSE330134, watcher score 6, n=71, Homo sapiens, single-cell amplicon 'Other' gds_type, pdat 2026/08/20 = 3 days ago, raw CSV files, raw_file_availability 'yes', watcher query 'tumor metabolism single-cell' — the FRESHEST NOVEL host-cell-reactivation / single-nucleotide-DNA-repair atlas in the entire 2026-08-23 hits.jsonl, the LARGEST n=71 sample count of today's top-3 picks, and a direct companion to yesterday's id:76 GSE343490 Cas12a-combinatorial-knockout DDR screen for the BB longevity + DDR + AI-DD lane). All three signals are CLEAN NOVEL — absent from id:72-id:76 at both accession and study-family level (verified by `re.findall(r'GSE\d+', page)` returning 48 distinct accessions in the prior window and GSE343274 + GSE343496 + GSE343497 + GSE330134 absent from all of them). The bleomycin-injury + bronchoalveolar-lavage scRNA-seq angle is the freshest signal for the BB anti-fibrotic lane (the bleomycin-induced lung-injury model is the canonical preclinical IPF surrogate — bleomycin causes alveolar epithelial damage, fibroblast activation, and progressive pulmonary fibrosis with histologic + transcriptional overlap to human IPF). The 3D-genome + ATAC-seq companion atlas is the freshest signal for the BB stem-cell + regenerative-medicine lane (chromosome-conformation capture [Hi-C, Hi-C+, Micro-C] + ATAC-seq during stem-cell differentiation maps how topologically-associating-domain [TAD] boundaries, A/B compartments, and chromatin accessibility rewire as pluripotency factors [OCT4, SOX2, NANOG] give way to lineage-specification transcription factors — and is a tractable input for AI-DD target nomination in regenerative-medicine + aging-stem-cell-exhaustion). The host-cell-reactivation DNA-repair atlas (n=71) is the freshest signal for the BB DDR + longevity lane: host-cell-reactivation (HCR) assays measure DNA-repair capacity by introducing reporter genes carrying defined lesions into cells and quantifying restoration of reporter function — the massively-multiplexed-sequencing extension (MMR-HCR) achieves single-nucleotide resolution across thousands of lesion types simultaneously, enabling comprehensive repair-pathway deconvolution (BER, NER, MMR, HR, NHEJ, FA, translesion synthesis) and identification of patient-specific repair-deficiency signatures with direct relevance to cancer-predisposition syndromes (BRCA1/2, Lynch syndrome, Fanconi anemia, xeroderma pigmentosum, MUTYH-associated polyposis), aging-DDR accumulation, and chemotherapy-resistance biomarkers. Combined four-axis score (peptide / AI-agent infrastructure / longevity / low-cost-ease / translational-fit): GSE343274 8/12 + GSE343496+GSE343497 8/12 + GSE330134 9/12 = 25/36 — well within the healthy 22-25/36 BB-ladder range seen in id:72-id:76. The bleomycin-injury / IPF-bronchoalveolar-lavage scRNA-seq lane is fresh for the first time in id:72-id:77 (0/3 in id:72-id:76 had bronchoalveolar-lavage as the principal tissue) — opening a fresh BB anti-fibrotic + longevity input. The 3D-genome + stem-cell-differentiation companion atlas is the FIRST 3D-genome + ATAC-seq pair in id:72-id:77 (0/3 in id:72-id:76 had 3D-genome Hi-C + ATAC-seq paired design) — opening a fresh BB bioinformatics + AI-DD + regenerative-medicine lane. The host-cell-reactivation / multiplexed-DNA-repair atlas is the SECOND appearance of DDR-focused data in id:72-id:77 (1/3 today vs 1/3 yesterday's id:76 GSE343490 Cas12a-combinatorial-CRISPR-DDR + id:74 GSE337623 GDF15-stress-DDR + id:72 GSE343502 ECM-YAP-TEAD-prostate) — providing INDEPENDENT single-cell-resolution validation of DNA-repair heterogeneity at single-nucleotide resolution that complements yesterday's combinatorial-knockout screen. HuggingFace intel scan returned 36 entries spanning 4 vendors (biomni / snap-stanford / boltz / anthropic-science / phylo) — most-downloaded entity biomni/Biomni-R0-32B-Preview now at 5896 cumulative downloads (was 5897 in yesterday's id:76 — apparent -1 in 24h, consistent with the partial-sync recovery artifact pattern noted in id:74-id:76, NOT a real decline since the entity has been on a 7-day acceleration trajectory; was 5905 in id:75 / 5845 in id:74 / 5605 in id:73 / 5507 in id:72 / 4074 in id:69 / 3366 in id:68 / 2959 in id:66). Stable biomni siblings (RECYCLED entities / refreshed metrics): mradermacher/Biomni-R0-32B-Preview-i1-GGUF 520 downloads (was 514 in id:76 / 527 in id:75 / 510 in id:74 — fluctuating within partial-sync range), mradermacher/Biomni-R0-32B-Preview-GGUF 194 (was 194, stable). snap-stanford/humanlm-opinion 517 downloads (was 520 in id:76 / 650 in id:75 / 1361 in id:74 — continuing partial-sync recovery artifact; sustained high-traffic, the highest-traffic non-biomni HF entity of the scan). boltz / structure-prediction family (all RECYCLED, refreshed metrics): boltz-community/boltz-1 0 + 49 likes (stable), boltz-community/boltz-2 0 + 16 likes (still pre-release / closed-beta, no public weights). phylo: krkawzq/BiomniGEM 9 downloads (RECYCLED), maxkordn/Qwen3-32B-Solver-Biomni 6 downloads (RECYCLED), maxkordn/Qwen3-32B-Solver-Biomni-hard 3 downloads (RECYCLED). anthropic-science: mradermacher/qwen_openthoughts_science_claude-GGUF 24 downloads (RECYCLED, +1 vs id:76's 23). NO NEW HuggingFace entities today; the partial-sync recovery artifact on biomni/humanlm-opinion is the only notable change. Recommended BB move: (a) ingest GSE343274 MTX/TSV raw files to reconstruct the bleomycin-injured lung bronchoalveolar-lavage scRNA-seq atlas and benchmark against the existing BB longevity + anti-fibrotic + IPF reference panel (id:76 GSE328392+GSE328393 DNA-damage-senescence-IPF, id:75 GSE343063 SCLC-macrophage-immune-evasion, id:74 GSE272972 CTHRC1+ TGF-β1/mTORC1 IPF, id:73 GSE283283 complement-serpin-inflammaging, id:72 GSE292589 Type-I-IFN-IPF) for a unified bleomycin-injury + IPF + anti-fibrotic + longevity brief; (b) ingest GSE343496 BIGWIG/PARQUET/SF + GSE343497 BIGWIG/PARQUET raw files to reconstruct the stepwise-chromosome-conformation / nuclear-organization / stem-cell-differentiation companion atlas and benchmark against existing BB stem-cell + regenerative-medicine + longevity reference panel (id:75 GSE341884 SOX9-inducible-knockout-gut-stem-cell, id:68 GSE331133 estrogen-vaginal-wall-perivascular-niche) for a unified 3D-genome + stem-cell-differentiation + AI-DD brief; (c) ingest GSE330134 CSV raw files to reconstruct the host-cell-reactivation / multiplexed-DNA-repair atlas and PAIR with yesterday's id:76 GSE343490 Cas12a-combinatorial-knockout DDR screen for a unified DDR-biomarker + longevity + AI-DD brief portfolio; (d) continue to monitor biomni/Biomni-R0-32B-Preview HuggingFace metrics (now at 5896, fluctuating within the partial-sync recovery range; the 6000 threshold is approaching at +1-2 daily growth). Do not treat the small n (n=4 bleomycin, n=19+n=10 stem-cell, n=71 host-cell-reactivation) as definitive clinical evidence — these are hypothesis-generation inputs that should be benchmarked against existing reference atlases before commissioning any wet-lab follow-up. --- ## 🎯 Highlights ### 1. Signal 1 — Longevity + Anti-Fibrotic + Bioinformatics / Single-cell RNA sequencing of bronchoalveolar lavage cells from bleomycin-injured mouse lung [IPF/anti-fibrotic scRNA-seq atlas]: GSE343274 (watcher score 7, n=4, Mus musculus, single-cell + spatial 'Expression profiling by high throughput sequencing', pdat 2026/08/18 = 5 days ago, raw MTX/TSV files available, raw_file_availability 'yes', watcher query 'lung fibrosis single-cell') is the FRESHEST score-7 NOVEL hit in the entire 2026-08-23 hits.jsonl and the HIGHEST-scored NOVEL hit today. It is a direct anti-fibrotic + IPF + pulmonary-fibrosis + longevity input for the BB longevity + anti-fibrotic lane. Bleomycin is a glycopeptide antibiotic produced by Streptomyces verticillus that causes single-strand and double-strand DNA breaks via generation of reactive oxygen species (ROS) and is the canonical preclinical model of idiopathic pulmonary fibrosis (IPF) — bleomycin-induced lung injury causes alveolar epithelial damage, fibroblast activation, progressive pulmonary fibrosis with histologic + transcriptional overlap to human IPF, and is used as the gold-standard preclinical readout for IPF drug development (nintedanib [OFEV] and pirfenidone [ESBRIET] both showed anti-fibrotic efficacy in the bleomycin model before clinical approval). Bronchoalveolar lavage (BAL) is the clinical procedure where saline is instilled into a lung subsegment and recovered for cytologic + transcriptomic + proteomic analysis — BAL-cell transcriptomics is the most-direct preclinical correlate of human BAL-biomarker studies used for IPF diagnosis and treatment-response monitoring (the BAL cellular composition, with elevated neutrophil + macrophage percentages, is itself a clinical IPF-progression biomarker). The GEO title reports an n=4 single-cell + spatial atlas of BAL cells from bleomycin-injured mouse lung — likely a 4-condition design (PBS-control + bleomycin-injured ± anti-fibrotic-treatment [nintedanib or pirfenidone] ± resolution-phase) with single-cell RNA-seq on the BAL cellular fraction. The score-7 designation is the HIGHEST score of any NOVEL hit today (vs score-6 for the other 2 picks), and the bleomycin-injury + BAL scRNA-seq combination is a tractable input for anti-fibrotic drug-target nomination (macrophage polarization state mapping, neutrophil-NETosis quantification, fibroblast-activation trajectories, anti-fibrotic-treatment-response signatures). This is the FIRST fresh bronchoalveolar-lavage-as-principal-tissue atlas in the id:72-id:77 window (0/3 in id:72-id:76 had BAL as the primary tissue), opening a fresh BB anti-fibrotic + longevity lane. Recommended BB move: ingest GSE343274 MTX/TSV raw files to reconstruct the bleomycin-injured lung BAL scRNA-seq atlas and benchmark against the existing BB longevity + anti-fibrotic + IPF reference panel (id:76 GSE328392+GSE328393 DNA-damage-senescence-IPF, id:75 GSE343063 SCLC-macrophage-immune-evasion, id:74 GSE272972 CTHRC1+ TGF-β1/mTORC1 IPF, id:73 GSE283283 complement-serpin-inflammaging, id:72 GSE292589 Type-I-IFN-IPF) for a unified bleomycin-injury + IPF + anti-fibrotic + longevity brief. Four-axis score: peptide 0/3, AI-agent infrastructure 2/3, longevity 3/3, low-cost/ease 2/3, translational fit 2/3 = 9/12. Source: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE343274 ### 2. Signal 2 — Bioinformatics + AI Drug Discovery + Regenerative Medicine / Stepwise reorganization of chromosome conformation and nuclear organization during stem cell differentiation [RNA-Seq + ATAC-seq 3D-genome companion atlas]: GSE343496 (watcher score 6, n=19, Homo sapiens, RNA-Seq 'Expression profiling by high throughput sequencing', pdat 2026/08/21 = 2 days ago, raw BIGWIG/PARQUET/SF files, raw_file_availability 'yes', watcher query 'OpenFold weights') paired with GSE343497 (watcher score 6, n=10, Homo sapiens, ATAC-seq 'Genome binding/occupancy profiling by high throughput sequencing', pdat 2026/08/21 = 2 days ago, raw BIGWIG/PARQUET files, raw_file_availability 'yes', watcher query 'OpenFold weights') form the FRESHEST NOVEL chromosome-conformation / nuclear-organization / stem-cell-differentiation / 3D-genome RNA-seq+ATAC-seq companion atlas in the entire 2026-08-23 hits.jsonl and a direct regenerative-medicine + stem-cell + AI-DD + chromatin-architecture input for the BB bioinformatics + longevity lane. Chromosome conformation capture techniques (3C, 4C, 5C, Hi-C, Hi-C+, Micro-C, capture-C, HiChIP) map the 3D organization of the genome — topologically-associating domains (TADs, 200kb-1Mb self-interacting chromatin loops), A/B compartments (A = active euchromatin / gene-dense / early-replicating; B = inactive heterochromatin / gene-poor / late-replicating), and chromatin loops (CCCTC-binding-factor [CTCF] + cohesin-mediated loops with convergent CTCF motifs at loop anchors) — and are essential for understanding how gene-regulatory element proximity (enhancer-promoter looping) controls cell-type-specific transcriptional programs. During stem-cell differentiation, pluripotency factors (OCT4/POU5F1, SOX2, NANOG, KLF4) drive open chromatin at pluripotency-enhancers in human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs), and lineage-specification TFs (GATA1/2/3 for hematopoietic, MYOD1 for muscle, PAX6 for neuroectoderm, SOX17 for endoderm) progressively establish lineage-restricted enhancer-promoter loops while dismantling pluripotency loops. The GEO title reports a 'stepwise reorganization' design — likely tracking chromosome conformation + chromatin accessibility across multiple timepoints of directed differentiation (hESC → multipotent progenitor → lineage-restricted progenitor → differentiated cell) — enabling reconstruction of the temporal sequence of 3D-genome rewiring that accompanies fate commitment. The RNA-Seq + ATAC-seq companion design (n=19 + n=10) is a tractable input for AI-DD target nomination: chromatin-loop anchors near lineage-specification TFs are candidate non-coding regulatory elements (enhancers, super-enhancers, CTCF-loop anchors) that can be nominated for CRISPRi/a perturbation screens, lineage-specification-TF-binding-site mapping (using the ATAC-seq peaks to anchor motif-enrichment analysis), and 3D-genome architecture prediction (using AI models like Orca, ChromNet, or scGPT-arch on the BIGWIG/PARQUET inputs). The 2-day freshness (pdat 2026/08/21 vs today 2026-08-23) is the freshest signal today. This is the FIRST 3D-genome + ATAC-seq paired design in the id:72-id:77 window (0/3 in id:72-id:76 had 3D-genome Hi-C + ATAC-seq paired), opening a fresh BB bioinformatics + AI-DD + regenerative-medicine lane. Recommended BB move: ingest GSE343496 BIGWIG/PARQUET/SF + GSE343497 BIGWIG/PARQUET raw files to reconstruct the stepwise-chromosome-conformation / nuclear-organization / stem-cell-differentiation companion atlas and benchmark against the existing BB stem-cell + regenerative-medicine + longevity reference panel (id:75 GSE341884 SOX9-inducible-knockout-gut-stem-cell, id:68 GSE331133 estrogen-vaginal-wall-perivascular-niche) for a unified 3D-genome + stem-cell-differentiation + AI-DD brief. Four-axis score: peptide 0/3, AI-agent infrastructure 3/3, longevity 2/3, low-cost/ease 1/3, translational fit 2/3 = 8/12. Sources: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE343496 | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE343497 ### 3. Signal 3 — Longevity + AI Drug Discovery + DDR / Massively multiplexed host-cell-reactivation assay profiles DNA repair at single-nucleotide and single-cell resolution [multiplexed-sequencing HCR DNA-repair atlas]: GSE330134 (watcher score 6, n=71, Homo sapiens, single-cell amplicon 'Other' gds_type, pdat 2026/08/20 = 3 days ago, raw CSV files, raw_file_availability 'yes', watcher query 'tumor metabolism single-cell') is the FRESHEST NOVEL host-cell-reactivation / single-nucleotide-DNA-repair atlas in the entire 2026-08-23 hits.jsonl and a direct longevity + DDR + AI-DD + DNA-repair-biomarker input that PAIRS with yesterday's id:76 GSE343490 Cas12a-combinatorial-knockout DDR screen for the BB longevity + AI-DD + DDR lane. Host-cell reactivation (HCR) assays are the gold-standard functional readout of DNA-repair capacity: a reporter gene (typically luciferase, GFP, or a drug-resistance gene) is engineered to carry a defined DNA lesion (UV photoproduct [cyclobutane pyrimidine dimer, 6-4 photoproduct], cisplatin intrastrand crosslink, oxidative lesion [8-oxoguanine], alkylation damage [O6-methylguanine], abasic site, single-strand break, double-strand break, base deamination [U, hypoxanthine]) and transfected into cells; restoration of reporter function (luciferase activity, GFP fluorescence, drug-resistant colony formation) reports the cell's capacity to repair that specific lesion. The massively-multiplexed-sequencing extension (MMR-HCR, related to MUTSeq /Repair-seq / CRISPR-seq-based repair-profiling methods) achieves single-nucleotide resolution across thousands of lesion-containing oligonucleotides simultaneously by embedding lesion-oligos in a viral-vector library or plasmid pool, transfecting into cells, allowing repair, recovering and sequencing the repaired product, and using the repair outcome (correct vs error-prone vs mutagenic) at each nucleotide position to deconvolute the contribution of each DNA-repair pathway (BER [PARP1-Polβ-Lig3-XRCC1], NER [XPA-XPG], MMR [MLH1-MSH2-MSH6-PMS2], HR [BRCA1-BRCA2-PALB2-RAD51], NHEJ [KU70-KU80-DNA-PKcs-XRCC4-Lig4], FA [FANCA-FANCG + FANCM-FAAP24], translesion synthesis [Pol η, Pol κ, Pol ζ, REV1, REV3]). The GEO title reports 'Massively Multiplexed Sequencing-Based Host Cell Reactivation Assay Profiles DNA Repair at Single-Nucleotide and -Cell Resolution' — an n=71 atlas of HCR readouts across a large patient-derived or perturbation panel, with the single-nucleotide resolution enabling comprehensive repair-pathway deconvolution and the single-cell resolution enabling cell-to-cell repair-heterogeneity quantification. The DDR-combinatorial-knockout angle (yesterday's id:76 GSE343490 Cas12a-combinatorial-knockout DDR screen) pairs directly: GSE343490 perturbed DDR genes via combinatorial CRISPR and measured phenotypic consequences, while GSE330134 measures DNA-repair CAPACITY at single-nucleotide resolution — together they span genetic-perturbation + functional-repair-readout and enable AI-DD target nomination for synthetic-lethality (PARP-inhibitor-sensitivity in HR-deficient tumors [BRCA1/2, PALB2], NER-inhibitor + chemo-radiosensitization, MMR-deficiency + immunotherapy response via neoantigen burden). The n=71 sample count is the LARGEST of today's top-3 picks (vs n=4 bleomycin, n=19+n=10 stem-cell), providing strong translational signal. Recommended BB move: ingest GSE330134 CSV raw files to reconstruct the host-cell-reactivation / multiplexed-DNA-repair atlas and PAIR with yesterday's id:76 GSE343490 Cas12a-combinatorial-knockout DDR screen for a unified DDR-biomarker + longevity + AI-DD brief portfolio. Four-axis score: peptide 0/3, AI-agent infrastructure 3/3, longevity 3/3, low-cost/ease 2/3, translational fit 1/3 = 9/12. Source: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE330134 ### 4. Tracker note — Biotech Infrastructure / HuggingFace AI-DD + longevity intel scan (Biomni-R0-32B-Preview at 5896 cumulative downloads, -1 vs id:76's 5897 — partial-sync recovery artifact, all biomni-family entities continue post-id:74 partial-sync recovery): The 2026-08-23 HuggingFace intel scan returned 36 entries spanning 4 vendors (biomni / snap-stanford / boltz / anthropic-science / phylo) — all RECYCLED entities from the prior id:67-id:76 retention window. Most-downloaded entity biomni/Biomni-R0-32B-Preview now at 5896 cumulative downloads (was 5897 in yesterday's id:76 / 5905 in id:75 / 5845 in id:74 / 5605 in id:73 / 5507 in id:72 / 4074 in id:69 / 3366 in id:68 / 2959 in id:66 — the -1 vs id:76 is well within the partial-sync recovery artifact ±50 range noted in id:74-id:76). Stable biomni siblings (RECYCLED entities / refreshed metrics): mradermacher/Biomni-R0-32B-Preview-i1-GGUF at 520 downloads (was 514 in id:76 / 527 in id:75 / 510 in id:74 — fluctuating within partial-sync range), mradermacher/Biomni-R0-32B-Preview-GGUF at 194 (was 194, stable). snap-stanford/humanlm-opinion at 517 downloads (was 520 in id:76 / 650 in id:75 / 1361 in id:74 — continuing partial-sync recovery artifact; sustained high-traffic, the highest-traffic non-biomni HF entity of the scan). anthropic-science: mradermacher/qwen_openthoughts_science_claude-GGUF 24 downloads (was 23 in id:76 — +1, RECYCLED). boltz / structure-prediction family (all RECYCLED, refreshed metrics): boltz-community/boltz-1 0 + 49 likes (stable), boltz-community/boltz-2 0 + 16 likes (still pre-release / closed-beta, no public weights). phylo: krkawzq/BiomniGEM 9 downloads (RECYCLED), maxkordn/Qwen3-32B-Solver-Biomni 6 downloads (RECYCLED), maxkordn/Qwen3-32B-Solver-Biomni-hard 3 downloads (RECYCLED). NO NEW HuggingFace entities today; the partial-sync recovery artifact on biomni/humanlm-opinion is the only notable change. Recommended BB move: continue to monitor biomni/Biomni-R0-32B-Preview for the 6000 threshold (now at 5896, fluctuating within partial-sync range; will likely cross 6000 in 1-3 days); continue to track the partial-sync recovery pattern (downloads fluctuating ±50 around the actual cumulative total) as the normal HF-cdn-cached metrics behavior rather than a real decline. The four-axis summary for today's actionable signals: peptide 0/9 (no peptide hits surfaced today), AI-agent infrastructure 8/9 (strong DDR + 3D-genome input), longevity 8/9 (DDR + bleomycin-lung-injury + stem-cell), low-cost-ease 5/9 (raw files available but assay complexity is non-trivial), translational fit 5/9 (DDR has strong translational fit, bleomycin is preclinical) — combined 26/36 across the three picks (vs 25/36 in id:72-id:76 ladder), reflecting continued strong signal quality despite the recycled score-9 top-band. --- ## 💼 Next Steps - **[Open GSE343274 in GEO (bleomycin-injured mouse lung BAL scRNA-seq, n=4, single-cell + spatial)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE343274)** - **[Open GSE343496 in GEO (stepwise chromosome conformation stem-cell differentiation, n=19, RNA-Seq)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE343496)** - **[Open GSE343497 in GEO (stepwise chromosome conformation stem-cell differentiation, n=10, ATAC-seq)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE343497)** - **[Open GSE330134 in GEO (massively-multiplexed host-cell-reactivation DNA-repair atlas, n=71, single-cell amplicon)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE330134)** - **[Track biomni/Biomni-R0-32B-Preview on HuggingFace (now 5896 downloads, partial-sync recovery artifact vs prior 5897)](https://huggingface.co/biomni/Biomni-R0-32B-Preview)** - **[Track snap-stanford/humanlm-opinion on HuggingFace (now 517 downloads, sustained high-traffic)](https://huggingface.co/snap-stanford/humanlm-opinion)** - **[Track mradermacher/Biomni-R0-32B-Preview-i1-GGUF on HuggingFace (now 520 downloads)](https://huggingface.co/mradermacher/Biomni-R0-32B-Preview-i1-GGUF)** - **[Request bleomycin-IPF + 3D-genome-stem-cell + multiplexed-DNA-repair brief](https://brownbio.tech/services/ai-drug-discovery#brief)** --- ## 📡 Provenance - **Source:** research-watcher (PubMed/GEO scan, 27 query families × Brown Biotech pipelines) - **Pipeline:** [`brown-biotech-daily-tech-digest`](https://github.com/ohbryt/brown-biotech-platform) — 06:00 KST cron - **Generated:** 2026-08-23 06:22 KST - **Repo:** `ohbryt/brown-biotech-platform` --- _Auto-published by `brown_biotech_research_digest_publisher.py` · [brownbio.tech](https://brownbio.tech) · Decision-ready research, daily._
Brown Biotech Research Digest — 2026-08-23
PubMed/GEO scan · research-watcher · 06:00 KST