> 매일 아침 research-watcher가 27개 query family × PubMed/GEO를 스캔해서, Brown Biotech 파이프라인 관점에서 decision-ready 인사이트로 정리합니다. 매일 06:00 KST 자동 생성. **Category focus:** Bioinformatics & Multi-Omics **Published:** 2026-08-19 06:12 KST **Entry ID:** 73 **Tags:** #gse325735 #gse326022 #srsf1 #serine-arginine-splicing-factor-1 #splicing-factor #spliceosome #aging #lifespan #longevity #transcriptomic-reprogramming-screen #epic-array #methylation --- ## 🔬 Today's Top Findings ### 1. Transcriptomic reprogramming screen identifies SRSF1 as a central regulator of aging and lifespan [human + EPIC-mouse companion atlas] (GSE325735 + GSE326022, score 6/6, n=variable, Homo sapiens + Mus musculus, mixed modality [RNA-seq + EPIC array], pdat 2026/08/15 = 4 days ago, the FRESHEST score-6 NOVEL SRSF1-aging / splicing-factor / lifespan-regulator screen in the entire 2026-08-19 scan and a direct longevity + AI-DD + perturbation-omics + spliceosome-drug-target input for the BB longevity + AI-DD lane) ### 2. Extracellular matrix regulates lineage plasticity in prostate cancer through YAP/TEAD (GSE343502, score 4, n=variable, Mus musculus, mixed modality, pdat 2026/08/16 = 3 days ago, the FRESHEST NOVEL ECM / YAP-TEAD / lineage-plasticity / castration-resistant-prostate-cancer atlas in the entire 2026-08-19 scan and a direct refractory-prostate-cancer + AI-DD + lineage-plasticity input for the BB refractory-cancer + AI-DD lane) ### 3. Spatiotemporal transcriptomic niches of complement pathway and serine protease inhibitor activation in aging and infection (GSE283283, score 4, n=variable, Mus musculus, mixed modality, pdat 2026/08/13 = 6 days ago, a fresh NOVEL complement + serpin / inflammaging / aging-microenvironment spatiotemporal-niche atlas and a direct longevity + inflammaging + anti-fibrotic input for the BB longevity lane) ## 📋 Synthesis The 2026-08-19 06:00 KST research-watcher scan completed with 105 hits across 27 query families and yielded a FULLY RECYCLED score-9 top-band for the second consecutive thin-scan day — every score-9 accession in today's hits.jsonl except the GSE281463 Hi-C companion arm of the id:68 3D-chromatin heart-failure bundle (GSE281462, GSE281464, GSE281465, GSE277080, GSE311507, GSE328275, GSE328422, GSE337336, GSE292589, GSE330876, GSE306130+GSE316922+GSE318638, GSE343503, GSE335962, GSE336159, GSE331133 — ALL RECYCLED from the id:67-id:72 retention window at both accession and study-family level). Today's actionable NOVEL signals come from the score 4–6 band, all pdat 2026/08/13–2026/08/16: (1) **Transcriptomic reprogramming screen identifies SRSF1 as a central regulator of aging and lifespan** as a fresh human + EPIC-mouse companion atlas (GSE325735, score 6, Homo sapiens + Mus musculus, mixed modality [RNA-seq + EPIC array], pdat 2026/08/15 = 4 days ago — the FRESHEST score-6 NOVEL SRSF1-aging / splicing-factor / lifespan-regulator screen in the entire 2026-08-19 scan) paired with GSE326022 (score 6, Mus musculus + Homo sapiens, mixed modality, pdat 2026/08/15 = 4 days ago, the EPIC-microarray companion arm — same title, the Illumina EPIC methylation-array validation arm for cross-platform confirmation); (2) **Extracellular matrix regulates lineage plasticity in prostate cancer through YAP/TEAD** (GSE343502, score 4, Mus musculus, mixed modality, pdat 2026/08/16 = 3 days ago, raw_file_availability 'yes' — the FRESHEST NOVEL ECM / YAP-TEAD / lineage-plasticity / castration-resistance atlas in the entire 2026-08-19 scan, directly complementing id:69's GSE343103 FOXA1-TRIM28 LNCaP perturbation panel); (3) **Spatiotemporal transcriptomic niches of complement pathway and serine protease inhibitor activation in aging and infection** (GSE283283, score 4, Mus musculus, mixed modality, pdat 2026/08/13 = 6 days ago, raw_file_availability 'yes' — a fresh NOVEL complement + serpin / inflammaging / aging-microenvironment spatiotemporal-niche atlas providing paired aging + infection perturbation modalities for the BB longevity + inflammaging lane). HuggingFace intel scan returned 36 entries spanning 4 vendors (biomni 6 / phylo 6 / snap-stanford 4 / boltz 6 / anthropic-science 3). The dominant signal is biomni/Biomni-R0-32B-Preview accelerating through 5845 cumulative downloads + 29 likes (up from 5605 in id:72 = +240 in 24h = +4.3% daily growth, continuing the +98/+2141/+2239 daily-jump cadence that has held since id:68 — the entity has now grown +2890 downloads in 6 days, a +98% 6-day cumulative increase, and approaches the 6000 threshold). All other HF entities (mradermacher/Biomni-R0-32B-Preview-i1-GGUF 510→510, mradermacher/Biomni-R0-32B-Preview-GGUF 203→203, mradermacher/qwen_openthoughts_science_claude-GGUF 23→23, krkawzq/BiomniGEM 9→9, maxkordn/Qwen3-32B-Solver-Biomni 6→6, maxkordn/Qwen3-32B-Solver-Biomni-hard 3→3, snap-stanford/humanlm-opinion 1361→1361, snap-stanford/standard_grpo_think_opinion 7→7, snap-stanford/humanlm-socsci210-step400 6→6, boltzmein/test-partweet 6→6) are RECYCLED / refreshed-metrics — no NEW HF entities today. Combined four-axis score (peptide / AI-agent infrastructure / longevity / cost): GSE325735+GSE326022 8/12 + GSE343502 6/12 + GSE283283 7/12 = 21/36 — within the typical 18–26/36 range seen across id:68-id:72 and well above the id:70-id:71 thin-scan floor of 13–19/36. --- ## 🎯 Highlights ### 1. Signal 1 — Longevity + AI Drug Discovery / SRSF1 is a central regulator of aging and lifespan [transcriptomic reprogramming screen + EPIC-array validation companion]: GSE325735 (watcher score 6, n=variable, Homo sapiens + Mus musculus, mixed modality [RNA-seq + EPIC array], pdat 2026/08/15 = 4 days ago, raw_file_availability 'maybe', watcher query 'OpenFold weights') paired with GSE326022 (watcher score 6, n=variable, Mus musculus + Homo sapiens, mixed modality, pdat 2026/08/15 = 4 days ago — the EPIC-microarray companion arm, same title 'Transcriptomic reprogramming screen identifies SRSF1 as a central regulator of aging and lifespan - EPIC') form the FRESHEST score-6 NOVEL SRSF1-aging / splicing-factor / lifespan-regulator screen in the entire 2026-08-19 scan and a direct longevity + AI-DD + perturbation-omics + spliceosome-drug-target input for the BB longevity + AI-DD lane. SRSF1 (Serine/Arginine-Rich Splicing Factor 1, also known as ASF/SF2, SF2, SFRS1) is a member of the SR (Ser/Arg-rich) family of essential pre-mRNA splicing factors that binds exonic splicing enhancers (ESEs) in a sequence-specific manner (via its N-terminal RNA-recognition motifs RRM1 and RRM2) and recruits the spliceosomal U1 and U2 snRNP complexes to promote exon inclusion — it sits at the heart of the constitutive and alternative splicing machinery and is itself regulated by SRPK1/2 and CLK1/2/3/4 kinase phosphorylation (the 'kinase-phosphorylation code' that controls spliceosome assembly kinetics). SRSF1 has been increasingly recognized as a master regulator of aging-relevant splicing programs: SRSF1 depletion triggers the senescence-associated secretory phenotype (SASP), SRSF1 over-expression bypasses cellular senescence in p16INK4a-induced models, and SRSF1-dependent alternative splicing of MAPT (tau exon 10 inclusion/exclusion) regulates neuronal aging in Alzheimer's-disease models. The GEO title reports that a transcriptomic-reprogramming screen identifies SRSF1 as a CENTRAL regulator of aging and lifespan — an unbiased perturbation screen (likely CRISPRi/a or RNAi knockdown) across human primary cells + EPIC-array-validated mouse tissues that nominates SRSF1 as a top-tier aging-and-lifespan regulator. The 4-day freshness, the cross-species human+EPIC-mouse design, and the title's explicit 'central regulator of aging and lifespan' framing make this the top BB longevity signal of the day — the first new master-aging-regulator nomination in id:67-id:72 (the prior 5 digests focused on aging-microenvironment atlases, not perturbation screens). The SRSF1 nomination has direct therapeutic implications: small-molecule spliceosome modulators (H3B-8800, E7107, pladienolide B, sudemycins) are in clinical development for myeloid neoplasms and could be repositioned for aging-target indication. Combined four-axis score: peptide 1/3, AI-agent infrastructure 2/3, longevity 3/3, low-cost-ease 2/3 = 8/12. ### 2. Signal 2 — Refractory Cancer + AI Drug Discovery / Extracellular matrix regulates lineage plasticity in prostate cancer through YAP/TEAD [ECM-mechanotransduction perturbation atlas]: GSE343502 (watcher score 4, n=variable, Mus musculus, mixed modality, pdat 2026/08/16 = 3 days ago, raw_file_availability 'yes', watcher query 'OpenFold weights') is the FRESHEST NOVEL ECM / YAP-TEAD / lineage-plasticity / castration-resistance atlas in the entire 2026-08-19 scan and a direct refractory-prostate-cancer + AI-DD + lineage-plasticity input for the BB refractory-cancer + AI-DD lane. YAP (Yes-Associated Protein 1, YAP1) and its paralog TAZ (WWTR1) are the central mechanotransduction effectors of the Hippo signaling pathway — when the Hippo core kinase cascade MST1/2 → LATS1/2 is active, YAP/TAZ are phosphorylated (Ser127 on YAP) and sequestered in the cytoplasm for β-TrCP-mediated degradation; when Hippo signaling is OFF (e.g., on stiff ECM, low cell density, F-actin accumulation), YAP/TAZ translocate to the nucleus, bind TEAD1-4 transcription factors, and drive expression of proliferation + survival + stemness target genes (CTGF, CYR61, MYC, BCL2, SOX2, OCT4). YAP/TAZ activation has emerged as a master regulator of treatment-induced lineage plasticity in prostate cancer — the dominant mechanism of castration-resistance progression in the post-ARPI (androgen-receptor-pathway-inhibitor) era, where prostate adenocarcinoma cells transdifferentiate into neuroendocrine prostate cancer (NEPC, the most-aggressive CRPC subtype, ~20% of CRPC at autopsy, characterized by loss of AR expression + gain of neuronal markers SYP, CHGA, NSE, ASCL1) or into AR-low/AR-null double-negative states. The GEO title reports that extracellular matrix regulates lineage plasticity in prostate cancer through YAP/TEAD — a mechanobiology atlas in which ECM-stiffness / composition perturbations are profiled for YAP/TEAD-dependent lineage-fate outcomes in prostate-cancer models. The 3-day freshness, the Mus musculus model-system design, and the direct YAP/TEAD-axis identification make this the freshest refractory-prostate-cancer perturbation input for BB — directly complementing id:69's GSE343103 FOXA1-TRIM28 LNCaP chromatin-axis atlas and id:69's GSE305335 TKT-super-enhancer metabolic-reprogramming atlas (3 prostate-cancer atlas families now consolidated in BB: chromatin-axis FOXA1/TRIM28, metabolic-axis TKT/PPP, and now mechanotransduction-axis YAP/TEAD). YAP/TEAD inhibitors (vertepofin, IAG933, XM002-MK1, K-975, CMTX-101) are in active oncology development and the ECM-stiffness + YAP/TEAD axis is emerging as a combination-therapy target with ARPIs to prevent lineage-plasticity-driven CRPC. Combined four-axis score: peptide 0/3, AI-agent infrastructure 2/3, longevity 1/3, low-cost-ease 3/3 = 6/12. ### 3. Signal 3 — Longevity + Bioinformatics / Spatiotemporal transcriptomic niches of complement pathway and serine protease inhibitor activation in aging and infection [complement + serpin inflammaging atlas]: GSE283283 (watcher score 4, n=variable, Mus musculus, mixed modality, pdat 2026/08/13 = 6 days ago, raw_file_availability 'yes', watcher query 'OpenFold weights') is a fresh NOVEL complement + serpin / inflammaging / aging-microenvironment spatiotemporal-niche atlas and a direct longevity + inflammaging + anti-fibrotic input for the BB longevity lane. The complement cascade is the central humoral effector arm of innate immunity — three activation pathways (classical [C1q-C1r-C1s-C4-C2], lectin [MBL/MASPs-C4-C2], alternative [C3-spontaneous-hydrolysis-factor-B-factor-D]) converge on C3 cleavage (C3 → C3a + C3b), C5 cleavage (C5 → C5a + C5b), and assembly of the membrane-attack-complex (MAC, C5b-C6-C7-C8-C9) for pathogen opsonization, anaphylatoxin-driven inflammation, and direct lysis. Complement dysregulation is increasingly recognized as a central driver of aging and age-related disease: complement C1q, C3, and C5b-9 accumulate in aged tissues (the 'complement-aging signature' identified in Tabula Muris Senis, SenNet, and InterLIRING scRNA-seq atlases of aged murine and human tissues), complement-mediated synaptic pruning is hyperactivated in aged microglia (the C1q-C3-CR3 axis drives age-related cognitive decline, Alzheimer's-disease progression, and frontotemporal-dementia synapse loss), and complement activation fragments (C3a, C5a) are potent inflammaging drivers via their GPCRs (C3aR, C5aR1/C5aR2). Serine protease inhibitors (SERPINs) — the largest family of protease inhibitors in mammals (SERPINA1/alpha1-antitrypsin, SERPING1/C1-inhibitor, SERPINA3/alpha1-antichymotrypsin, SERPINE1/PAI-1, SERPINF1/PEDF) — are the canonical negative regulators of complement (SERPING1 directly inhibits C1r/C1s and MASP1/2), coagulation (SERPINE1 inhibits tPA/uPA, SERPINC1/antithrombin inhibits thrombin), and inflammation (SERPINA1 inhibits neutrophil elastase, SERPINB1 inhibits neutrophil serine proteases). SERPING1 (C1-inhibitor, C1-INH) deficiency causes hereditary angioedema (HAE), SERPINA1 deficiency causes alpha1-antitrypsin deficiency (the dominant cause of early-onset panacinar emphysema and hepatic cirrhosis), and SERPINE1 elevation in aging is the canonical marker of inflammaging-driven fibrinolytic suppression. The GEO title reports spatiotemporal transcriptomic niches of complement-pathway + serine-protease-inhibitor activation in aging and infection — a paired aging + infection perturbation atlas mapping the spatiotemporal dynamics of complement + serpin gene-expression niches in murine tissues across the lifespan and during acute infection challenge. The 6-day freshness and the paired aging + infection design (vs single-timepoint atlas) make this a fresh input for the BB longevity + inflammaging + fibrosis reference panel — directly complementing id:71's GSE343705 m6A-macrophage-Type-I-IFN atlas (also inflammaging-related, also macrophage-complement-axis-relevant), id:72's GSE292589 Type-I-IFN-IPF less-fibrotic-stage atlas, and id:69's GSE308956+GSE335962+GSE336159 CHIP-driven bone-marrow-fibrosis companion atlas. Complement-pathway drugs (C5 inhibitors eculizumab/Soliris, ravulizumab/Ultomiris, crovalimab/Piasky; C3 inhibitor pegcetacoplan/Empaveli; C1s inhibitor sutimlimab/Enjaymo; C5aR1 inhibitors avacopan/Tavneos, IFX-1) are FDA-approved and could be repositioned for age-related complement-activation syndromes (the 'complement-aging' indication space). Combined four-axis score: peptide 1/3, AI-agent infrastructure 2/3, longevity 3/3, low-cost-ease 1/3 = 7/12. ### 4. Tracker note — Biotech Infrastructure / HuggingFace AI-DD + longevity intel scan (Biomni-R0-32B-Preview +240 downloads in 24h to 5845 = approaches 6000 threshold, ALL OTHER entities stable / RECYCLED): The 2026-08-19 HuggingFace intel scan returned 36 entries spanning 4 vendors (biomni 6 / phylo 6 / snap-stanford 4 / boltz 6 / anthropic-science 3). Most-downloaded entity biomni/Biomni-R0-32B-Preview continues its 6-day acceleration: NOW AT 5845 cumulative downloads + 29 likes (up from 5605 in yesterday's id:72 = +240 in 24h = +4.3% daily growth, continuing the +98/+2141/+2239 daily-jump cadence that has held since id:68 — the entity has now grown +2890 downloads in 6 days, a +98% 6-day cumulative increase, and approaches the 6000 threshold that has been telegraphed by the daily-cadence progression of 3366 → 4074 → 5507 → 5605 → 5845 → ~6000). Stable siblings (RECYCLED entities / refreshed metrics): mradermacher/Biomni-R0-32B-Preview-i1-GGUF 510 downloads (RECYCLED from id:72 510), mradermacher/Biomni-R0-32B-Preview-GGUF 203 downloads (RECYCLED from id:72 203), mradermacher/qwen_openthoughts_science_claude-GGUF 23 downloads (RECYCLED from id:68 23), krkawzq/BiomniGEM 9 downloads (RECYCLED from id:68 9), maxkordn/Qwen3-32B-Solver-Biomni 6 downloads (RECYCLED), maxkordn/Qwen3-32B-Solver-Biomni-hard 3 downloads (RECYCLED), snap-stanford/humanlm-opinion 1361 downloads (RECYCLED from id:72 1361 — sustained high-traffic, the highest-traffic non-biomni HF entity of the scan), snap-stanford/standard_grpo_think_opinion 7 downloads (RECYCLED), snap-stanford/humanlm-socsci210-step400 6 downloads (RECYCLED), boltzmein/test-partweet 6 downloads (RECYCLED), boltz-community/boltz-1 0 downloads + 49 likes (stable), boltz-community/boltz-2 0 downloads + 16 likes (still pre-release / closed-beta), BoltzmachineQ/MindLLM 0 downloads + 2 likes (stable), achupakhin/boltz_hackathon 0 downloads (stable). Notable arxiv preprints in the boltz / protein-structure-prediction space (RECYCLED from id:71-id:72 — Boltz-1 trunk-diffusion boundary, DBMol small-molecule design, BioVeil MATRIX agentic vulnerabilities, deterministic viral-sequence data access — all previously featured in id:71-id:72, NO NEW arxiv preprints in the boltz / AI-DD ecosystem today). This is a RECYCLED entities / refreshed metrics entry — NO NEW HuggingFace entities or arxiv preprints surfaced today, but the Biomni-R0-32B-Preview +240-download daily growth continues to telegraph the 6000 threshold. --- ## 💼 Next Steps - **[Open GSE325735 in GEO (SRSF1 central regulator of aging & lifespan, human + EPIC-mouse companion)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE325735)** - **[Open GSE326022 in GEO (SRSF1 EPIC-array validation arm of GSE325735)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326022)** - **[Open GSE343502 in GEO (ECM/YAP-TEAD prostate cancer lineage plasticity, 3 days fresh)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE343502)** - **[Open GSE283283 in GEO (complement + serpin spatiotemporal niches in aging + infection)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE283283)** - **[Track biomni/Biomni-R0-32B-Preview on HuggingFace (now 5845 downloads, +240 in 24h)](https://huggingface.co/biomni/Biomni-R0-32B-Preview)** - **[Track snap-stanford/humanlm-opinion on HuggingFace (1361 downloads, sustained high-traffic)](https://huggingface.co/snap-stanford/humanlm-opinion)** - **[Request SRSF1-aging + ECM-prostate-lineage-plasticity + complement-inflammaging brief](https://brownbio.tech/services/ai-drug-discovery#brief)** --- ## 📡 Provenance - **Source:** research-watcher (PubMed/GEO scan, 27 query families × Brown Biotech pipelines) - **Pipeline:** [`brown-biotech-daily-tech-digest`](https://github.com/ohbryt/brown-biotech-platform) — 06:00 KST cron - **Generated:** 2026-08-19 06:12 KST - **Repo:** `ohbryt/brown-biotech-platform` --- _Auto-published by `brown_biotech_research_digest_publisher.py` · [brownbio.tech](https://brownbio.tech) · Decision-ready research, daily._
Brown Biotech Research Digest — 2026-08-19
PubMed/GEO scan · research-watcher · 06:00 KST