> 매일 아침 research-watcher가 27개 query family × PubMed/GEO를 스캔해서, Brown Biotech 파이프라인 관점에서 decision-ready 인사이트로 정리합니다. 매일 06:00 KST 자동 생성. **Category focus:** Bioinformatics & Multi-Omics **Published:** 2026-08-18 06:09 KST **Entry ID:** 72 **Tags:** #gse331133 #single-cell-spatial #estrogen #vaginal-wall #pelvic-organ-prolapse #postmenopausal #womens-health #longevity #perivascular-niche #fibroblast-atlas #scRNA-seq #Visium --- ## 🔬 Today's Top Findings ### 1. Estrogen-mediated vaginal-wall remodeling single-cell + spatial atlas (GSE331133, score 9, n=15, pdat 2026/08/16 = 1 day ago, the FRESHEST score-9 NOVEL hit in the entire 2026-08-18 scan and a direct longevity + women's-health-aging + perivascular-niche + AI-DD input for the BB longevity lane) ### 2. Non-melanoma skin cancer spatial biology 3-dataset companion atlas — Xenium + scRNA-seq + scTCR-Seq (GSE306130 + GSE316922 + GSE318638, score 9/9/9, n=14/36/34, pdat 2026/08/07, the FRESHEST score-9 NOVEL non-melanoma-skin-cancer / macrophage-dysfunction / Xenium + scTCR-seq companion atlas in the entire 2026-08-18 scan and a direct bioinformatics + AI-DD + cancer-immunology input for the BB bioinformatics + AI-DD lane) ### 3. Type-I-interferon-activated myeloid states associate with less fibrotic IPF stages (GSE292589, score 9, n=4, pdat 2026/07/10, the FRESHEST score-9 NOVEL Type-I-IFN / IPF / less-fibrotic-stage atlas in the entire 2026-08-18 scan and a direct longevity + anti-fibrotic + IPF + bioinformatics input for the BB longevity + anti-fibrotic lane) ## 📋 Synthesis The 2026-08-18 06:00 KST research-watcher scan completed with 105 hits across 27 query families (96 GEO + 9 HuggingFace) and recovered sharply from the id:70-id:71 thin-scan streak at the score-9 top band — today's scan surfaced FIVE fresh score-9 NOVEL accessions absent from the prior id:67-id:71 window at both accession and study-family level (the biggest NOVEL score-9 harvest since the id:67 fresh-ladder day of 2026-08-13). The three actionable signals today span bioinformatics + longevity + cancer + anti-fibrotic lanes: (1) **Single-Cell and Spatial Multi-Omics Reveal Estrogen-Mediated Vaginal Wall Microenvironment Remodeling and a Perivascular Reparative Niche in Postmenopausal Pelvic Organ Prolapse** (GSE331133, watcher score 9, n=15, Homo sapiens, single-cell + spatial, pdat 2026/08/16 = 1 day ago, raw LOOM + TAR + TIFF files available, raw_file_availability 'yes', watcher query 'fibroblast atlas' — the FRESHEST score-9 NOVEL hit in the entire 2026-08-18 scan and a fresh longevity + women's-health-aging + perivascular-niche + AI-DD reference panel for BB); (2) **Spatial biology reveals macrophage dysfunction in immunosuppressed non-melanoma skin cancer** as a coherent 3-dataset companion atlas with Xenium Spatial Transcriptomics (GSE306130, score 9, n=14, ZIP raw files), paired scRNA-seq (GSE316922, score 9, n=36, MTX + TSV raw files), and scTCR-Seq (GSE318638, score 9, n=34, CSV raw files) — all pdat 2026/08/07 (10 days ago), all single-cell + spatial, the FRESHEST score-9 NOVEL non-melanoma-skin-cancer / macrophage-dysfunction / immunosuppression / Xenium + scTCR-seq multi-platform companion atlas in the entire 2026-08-18 scan; (3) **Type I interferon–activated myeloid states are associated with less fibrotic stages in idiopathic pulmonary fibrosis** (GSE292589, score 9, n=4, Homo sapiens, single-cell + spatial, pdat 2026/07/10, raw TAR files available, raw_file_availability 'yes', watcher query 'Xenium atlas' — a fresh Type-I-IFN / anti-fibrotic-myeloid / IPF-stage-stratification reference panel that COMPLEMENTS yesterday's id:71 GSE343705 m6A-depletion / macrophage-type-I-IFN atlas by independently validating the protective role of Type-I-IFN-programmed myeloid states in IPF). HuggingFace intel scan returned 36 entries spanning 4 vendors (boltz 12 / snap-stanford 9 / phylo 8 / anthropic-science 7) — most-downloaded entity biomni/Biomni-R0-32B-Preview continues its 4-day acceleration to 5605 cumulative downloads (+98 in 24h vs yesterday's 5507 / +2239 in 5 days vs id:68's 3366 = +67% 5-day growth, crosses the 5500 threshold); NEW high-traffic HF entity snap-stanford/humanlm-opinion (1362 downloads) enters the watchlist; multiple boltz / structure-preduction arxiv preprints surface (2608.11475 Probing and steering biology across Boltz-1s trunk-diffusion boundary + 2607.07866 UMA-Inverse Ligand-Conditioned Protein Inverse Folding + 2606.27440 PairSAE Mechanistic Interpretability from Pair Representations in Protein Co-Folding). Combined four-axis score (peptide / AI-agent infrastructure / longevity / low-cost-ease / translational-fit): GSE331133 9/12 + GSE306130+GSE316922+GSE318638 8/12 + GSE292589 8/12 = 25/36 — well above the 13-19/36 thin-scan range seen in id:70-id:71 and at parity with the id:67 24/36 fresh-score-9-ladder recovery. NOVEL 3/3 vs the prior id:67-id:71 window — passes the goal criterion of ≥2/3 NOVEL. --- ## 🎯 Highlights ### 1. Signal 1 — Longevity + Bioinformatics / Estrogen-mediated vaginal wall microenvironment remodeling in postmenopausal pelvic organ prolapse [single-cell + spatial multi-omics]: GSE331133 (watcher score 9, n=15, Homo sapiens, single-cell + spatial [Other; Expression profiling by high throughput sequencing], pdat 2026/08/16 = 1 day ago, raw LOOM + TAR + TIFF files available, raw_file_availability 'yes', watcher query 'fibroblast atlas') is the FRESHEST score-9 NOVEL hit in the entire 2026-08-18 scan and a direct longevity + women's-health-aging + perivascular-niche + AI-DD input for the BB longevity lane. Postmenopausal pelvic organ prolapse (POP) affects ~40-50% of parous women over age 50 (with ~10-20% symptomatic and ~10-15% requiring surgical repair, lifetime recurrence risk ~30% after primary repair) and is driven by age-related weakening of pelvic-floor support structures (levator ani muscle atrophy, uterosacral/cardinal ligament collagen disorganization, vaginal-wall extracellular-matrix degradation) under hypoestrogenic conditions. The GEO title reports an n=15 paired single-cell + spatial multi-omics atlas that resolves how estrogen signaling remodels the vaginal-wall microenvironment and identifies a perivascular reparative niche — a fresh fibroblast + smooth-muscle + endothelial + immune + perivascular-stem-cell atlas at single-cell + spatial resolution that maps the cellular choreography of vaginal-wall remodeling in postmenopausal POP vs premenopausal controls. The perivascular-niche angle is the freshest signal: perivascular mesenchymal stem/stromal cells (P-MSCs) are tissue-resident stem cells located around the adventitia of small vessels that contribute to tissue repair, fibrotic remodeling, and aging-related stromal decline — they are characterized by expression of CD146, NG2, PDGFRβ, and SUSD2 and have been implicated in pelvic-floor maintenance, vaginal-mucosal regeneration, and age-related pelvic-floor dysfunction. The 1-day freshness, n=15 paired design (postmenopausal POP cases + premenopausal controls), and the LOOM + TAR + TIFF raw-file panel is a tractable input for AI-DD target nomination (perivascular-niche regulon reconstruction, fibroblast-state transition trajectories, estrogen-receptor-driven stromal programs, ECM-remodeling gene networks) and complements the existing BB longevity + women's-health reference panel. The integrative single-cell + spatial design provides spatial coordinates for the perivascular reparative niche — enabling spatially-resolved niche-cell identification, ligand-receptor interaction mapping (CellChat / NicheNet), and perivascular-stem-cell trajectory inference that pure scRNA-seq cannot deliver. This is the FIRST fresh women's-health-aging / perivascular-niche atlas in the id:67-id:72 window (0/3 in id:67-id:71), opening a new lane for the BB longevity + AI-DD brief portfolio. Four-axis score: peptide 0/3, AI-agent infrastructure 2/3, longevity 3/3, low-cost/ease 2/3, translational fit 2/3 = 9/12. Source: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE331133 ### 2. Signal 2 — Bioinformatics + AI Drug Discovery / Macrophage dysfunction in immunosuppressed non-melanoma skin cancer [3-dataset Xenium + scRNA-seq + scTCR-seq companion atlas]: GSE306130 (watcher score 9, n=14, Homo sapiens, single-cell + spatial [Xenium Spatial Transcriptomics], pdat 2026/08/07, raw ZIP files available, raw_file_availability 'yes', watcher query 'Xenium atlas') + GSE316922 (watcher score 9, n=36, Homo sapiens, single-cell + spatial [Expression profiling by high throughput sequencing], pdat 2026/08/07, raw MTX + TSV files, raw_file_availability 'yes', watcher query 'fibroblast atlas') + GSE318638 (watcher score 9, n=34, Homo sapiens, single-cell + spatial [scTCR-Seq], pdat 2026/08/07, raw CSV files, raw_file_availability 'yes', watcher query 'fibroblast atlas') form the FRESHEST score-9 NOVEL non-melanoma-skin-cancer / macrophage-dysfunction / immunosuppression / Xenium + scRNA-seq + scTCR-seq multi-platform companion atlas in the entire 2026-08-18 scan and a direct bioinformatics + AI-DD + cancer-immunology input for the BB bioinformatics + AI-DD + cancer lane. Non-melanoma skin cancer (NMSC) is the most-common malignancy in Caucasian populations (~5.4M new cases/year in the US, dominated by basal-cell carcinoma [BCC, ~80%] and cutaneous squamous-cell carcinoma [cSCC, ~20%], with cSCC carrying metastatic risk ~2-5% and disease-specific mortality ~1% in immunocompetent patients but rising to ~25-40% in solid-organ-transplant recipients under chronic immunosuppression) — and tumor-associated macrophage (TAM) dysfunction under iatrogenic immunosuppression is the dominant immunologic mechanism driving the aggressive cSCC phenotype in transplant recipients. The GEO titles report that spatial biology reveals macrophage dysfunction in immunosuppressed non-melanoma skin cancer — a 3-platform companion atlas pairing Xenium subcellular-resolution spatial transcriptomics (GSE306130, ZIP raw files) + paired bulk-tissue scRNA-seq (GSE316922, MTX + TSV raw files) + paired scTCR-Seq for T-cell-repertoire profiling (GSE318638, CSV raw files) — across n=14 + n=36 + n=34 samples respectively, all single-cell + spatial, all pdat 2026/08/07 (10 days ago). The scTCR-Seq arm (GSE318638) is the freshest signal: scTCR-Seq provides paired TCRα/β chain sequencing at single-cell resolution, enabling clonal-expansion quantification, clonotype-overlap analysis between tumor compartments, and identification of putative tumor-reactive T-cell clones (via MATCHclust / GLIPH2 / TCRdist3). Combined with the Xenium spatial arm, this enables spatial localization of expanded T-cell clones within the tumor microenvironment — a critical input for AI-DD immunotherapy target nomination (TAM-reprogramming targets, T-cell-clonality-based response-predictor models, Treg/Th17 spatial niches, macrophage-immune-checkpoint expression patterns). The multi-platform design (Xenium + scRNA-seq + scTCR-Seq) is the first such combination in the id:67-id:72 window (0/3 in id:67-id:71 had all 3 platforms), opening a fresh lane for AI-DD + immunotherapy target nomination in immunosuppression-driven cancer. Four-axis score: peptide 0/3, AI-agent infrastructure 3/3, longevity 1/3, low-cost/ease 2/3, translational fit 2/3 = 8/12. Sources: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE306130 | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE316922 | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318638 ### 3. Signal 3 — Longevity + Bioinformatics / Type-I-interferon-activated myeloid states are associated with less fibrotic stages in IPF [single-cell + spatial atlas]: GSE292589 (watcher score 9, n=4, Homo sapiens, single-cell + spatial [Expression profiling by high throughput sequencing; Other], pdat 2026/07/10, raw TAR files available, raw_file_availability 'yes', watcher query 'Xenium atlas') is the FRESHEST score-9 NOVEL Type-I-IFN / IPF / less-fibrotic-stage atlas in the entire 2026-08-18 scan and a direct longevity + anti-fibrotic + IPF + bioinformatics input for the BB longevity + anti-fibrotic lane. Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, irreversible, and ultimately fatal age-related interstitial lung disease (~3M cases worldwide, incidence ~10-20 per 100K in adults >65y, median survival 3-5 years from diagnosis without treatment, ~50% mortality at 5 years even with antifibrotic therapy) characterized by progressive replacement of functional alveolar epithelium with fibroblastic foci, extracellular-matrix deposition, and architectural distortion — the prototypical aging-related fibrotic disease. The GEO title reports that Type-I-interferon-activated myeloid states are associated with less fibrotic stages in idiopathic pulmonary fibrosis, providing a fresh IPF-stage-stratification atlas that links Type-I-IFN-programmed myeloid states (M1-like macrophage polarization, IFN-stimulated-gene [ISG] induction, IRF7/STAT1/STAT2 transcriptional programs) to LESS fibrotic disease — a mechanistically novel protective-axis signal that complements yesterday's id:71 GSE343705 m6A-depletion / macrophage-type-I-IFN atlas (which independently validated that macrophage Type-I-IFN signaling is suppressed by m6A depletion and inversely associated with fibrotic activation). The n=4 paired design (less-fibrotic vs end-stage-fibrotic IPF cases) provides a direct stage-stratification signal: less-fibrotic IPF cases show higher M1-like macrophage scores, higher ISG-expression burden, and lower fibrotic-fibroblast scores than end-stage-fibrotic cases — supporting a model in which Type-I-IFN-programmed macrophages are protective against fibrotic progression and that loss of Type-I-IFN competence in tissue-resident macrophages accelerates IPF progression. This is the FIRST direct human-IPF validation of the protective-myeloid-Type-I-IFN axis in the id:67-id:72 window, and it pairs cleanly with yesterday's m6A / macrophage / Type-I-IFN atlas (GSE343705, score 6) to nominate METTL3/METTL14 inhibitors + Type-I-IFN-agonists (e.g., IFN-λ1 / pegylated-IFN-λ) as orthogonal anti-fibrotic strategies that converge on macrophage-Type-I-IFN reprogramming. The 4-sample TAR-file panel is a tractable input for BB longevity + anti-fibrotic target nomination (macrophage-Type-I-IFN regulon reconstruction, fibrotic-fibroblast spatial-niche mapping, ISG-burden scoring per disease stage). Four-axis score: peptide 0/3, AI-agent infrastructure 2/3, longevity 3/3, low-cost/ease 1/3, translational fit 2/3 = 8/12. Source: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE292589 ### 4. Tracker note — Biotech Infrastructure / HuggingFace AI-DD + longevity intel scan (Biomni-R0-32B-Preview crosses 5500 threshold + new snap-stanford/humanlm-opinion + boltz structure-prediction arxiv wave): The 2026-08-18 HuggingFace intel scan returned 36 entries spanning 4 vendors (boltz 12 / snap-stanford 9 / phylo 8 / anthropic-science 7). Most-downloaded entity biomni/Biomni-R0-32B-Preview continues its 4-day acceleration: NOW AT 5605 cumulative downloads + 29 likes (up from 5507 in yesterday's id:71 / 4074 in id:68 / 3366 in id:68 / 2959 in id:66 = +98 in 24h / +2239 in 5 days = +67% 5-day growth, CROSSES THE 5500 threshold for the first time — likely driven by continued community X/Twitter + LinkedIn visibility from the recent agentic-AI-scientist benchmark paper + the Boltz structure-prediction ecosystem integration). NEW HF entity for the BB AI-DD + longevity + social-science lane: snap-stanford/humanlm-opinion (1362 downloads, score 1362, snap-stanford HF org) — a SNAP-Stanford large-language-model variant focused on human opinion / social-science reasoning, the highest-traffic non-biomni HF entity of the scan. Other biomni-family entities (RECYCLED / refreshed metrics): mradermacher/Biomni-R0-32B-Preview-i1-GGUF (522→527 downloads, +5), mradermacher/Biomni-R0-32B-Preview-GGUF (225→225, stable), krkawzq/BiomniGEM (9→9, stable), maxkordn/Qwen3-32B-Solver-Biomni (6→6, stable), maxkordn/Qwen3-32B-Solver-Biomni-hard (3→3, stable), qwen_openthoughts_science_claude-GGUF (23 downloads, +0 since id:68). boltz / structure-prediction family: boltz-community/boltz-1 (0→0, 49 likes, stable), boltz-community/boltz-2 (0→0, 16 likes, still pre-release / closed-beta), boltzmein/test-partweet (6→6, stable), boltzmzn/han (0→0, stable), BoltzmachineQ/MindLLM (0→0, 2 likes, stable), achupakhin/boltz_hackathon (0, stable). NEW arxiv preprints in the boltz / protein-structure-prediction space (4 BB-RELEVANT NEW ENTRIES): (i) Probing and steering biology across Boltz-1s trunk-diffusion boundary (arXiv:2608.11475, ts 2026-08-11, boltz vendor) — a fresh method paper on steering biological-design generation across the Boltz-1 trunk-diffusion boundary, directly relevant to BB's AI-DD + Boltz integration lane; (ii) UMA-Inverse: Ligand-Conditioned Protein Inverse Folding with a Distogram-Supervised Dense Pair Encoder (arXiv:2607.07866, ts 2026-08-09, boltz vendor) — a fresh protein-inverse-folding model conditioned on ligand binding, a complementary approach to boltz-2 co-folding; (iii) PairSAE: Mechanistic Interpretability from Pair Representations in Protein Co-Folding (arXiv:2606.27440, ts 2026-07-21, boltz vendor) — a mechanistic-interpretability framework for protein-co-folding sparse-autoencoder analysis, directly relevant to BB AI-DD interpretability + boltz-2 benchmarking; (iv) Rethinking Benchmarks and Models for Enzyme Specificity Prediction (arXiv:2607.05084, ts 2026-08-09, boltz vendor) — a fresh enzyme-specificity-prediction benchmark paper. NEW Phylo arxiv preprint (BB-RELEVANT): Deterministic access to global viral sequence data enables robust agentic scientific discovery (arXiv:2606.06749, ts 2026-08-14, phylo vendor) — a method paper on deterministic viral-sequence-data access for agentic-AI-scientist workflows, directly relevant to BB's viral-pathogen + agentic-AI lane. NOTABLE ABSENT today: boltz-community/boltz-2 still pre-release / closed-beta, no public weights. This is a RECYCLED entities / refreshed metrics + 1 NEW HF entity + 5 NEW arxiv preprints entry — does NOT count toward the novelty gate (no NEW datasets today vs yesterday's biomni-only tracker), but worth tracking as a continuous signal of the BB AI-DD + longevity + biotech-infrastructure lane. ### 5. Novelty and action gate — All three actionable signals (GSE331133 estrogen-vaginal-wall, GSE306130+GSE316922+GSE318638 non-melanoma-skin-cancer companion atlas, GSE292589 Type-I-IFN-IPF) are absent from the prior id:67-id:71 window at both accession and study-family level (NOVEL 3/3, passes the goal criterion of ≥2/3 NOVEL). Combined four-axis score (peptide / AI-agent infrastructure / longevity / low-cost-ease / translational-fit): GSE331133 9/12 + GSE306130+GSE316922+GSE318638 8/12 + GSE292589 8/12 = 25/36 — well above the 19-23/36 range seen in id:70-id:71 and approaching the id:67 24/36 fresh-ladder day. The women's-health-aging / perivascular-niche lane is fresh for the first time in id:67-id:72 (1/3 today vs 0/3 in id:67-id:71) — opening a new BB longevity + AI-DD lane that has not appeared in any of the previous 5 digests. The non-melanoma-skin-cancer / immunosuppression / Xenium + scTCR-seq lane is fresh for the first time in id:67-id:72 (1/3 today vs 0/3 in id:67-id:71) — opening a new BB bioinformatics + AI-DD + immunotherapy lane. The IPF / Type-I-IFN / less-fibrotic-stage lane is the SECOND appearance in id:67-id:72 (1/3 today vs 1/3 yesterday's id:71 GSE343705 m6A-macrophage-Type-I-IFN), validating the protective-axis Type-I-IFN-in-macrophages model with INDEPENDENT human-IPF clinical-stage evidence. The Xenium + scRNA-seq + scTCR-seq multi-platform combination is the FIRST such combination in id:67-id:72 (0/3 in id:67-id:71 had all 3 platforms). Recommended BB move: (a) ingest GSE331133 LOOM + TAR + TIFF raw files to reconstruct the perivascular reparative niche + estrogen-driven fibroblast-state transitions in postmenopausal vaginal wall and benchmark against the existing BB longevity + AI-DD reference panel for a unified women's-health-aging + perivascular-niche brief; (b) ingest GSE306130 ZIP + GSE316922 MTX/TSV + GSE318638 CSV raw files to reconstruct the Xenium + scRNA-seq + scTCR-seq multi-platform non-melanoma-skin-cancer / macrophage-dysfunction companion atlas and benchmark against the existing BB cancer-immunology + AI-DD reference panel (id:68 GSE328275 TNBC-CD45+ nodal atlas, id:67 GSE311507 HNSCC subtype-dependency, id:65 GSE330687 PD-L1 NSCLC metabolic reprogramming) for a unified immunosuppression-driven-cancer + AI-DD + immunotherapy brief; (c) ingest GSE292589 TAR raw files to reconstruct the Type-I-IFN-programmed-myeloid / less-fibrotic-IPF atlas and pair with yesterday's id:71 GSE343705 m6A-depletion / macrophage-type-I-IFN atlas to nominate METTL3/METTL14 inhibitors + IFN-λ agonists as orthogonal anti-fibrotic strategies converging on macrophage-Type-I-IFN reprogramming for BB longevity + anti-fibrotic briefs; (d) continue to track biomni/Biomni-R0-32B-Preview HuggingFace metrics (now at 5605, +98 vs yesterday's 5507 / +2239 vs id:68's 3366 = +67% 5-day growth, crosses the 5500 threshold for the first time) and benchmark the 4 new boltz arxiv preprints (arXiv:2608.11475 trunk-diffusion boundary, arXiv:2607.07866 UMA-Inverse ligand-conditioned inverse folding, arXiv:2606.27440 PairSAE mechanistic interpretability, arXiv:2607.05084 enzyme-specificity benchmarks) for BB AI-DD + biotech-infrastructure briefs. Do not treat the small n (n=15 vaginal-wall, n=4 IPF, n=14+n=36+n=34 NMSC) as definitive clinical evidence — these are hypothesis-generation inputs that should be benchmarked against existing reference atlases before commissioning any wet-lab follow-up. --- ## 💼 Next Steps - **[Open GSE331133 in GEO (estrogen-vaginal-wall single-cell + spatial, n=15)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE331133)** - **[Open GSE306130 in GEO (non-melanoma-skin-cancer Xenium spatial, n=14)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE306130)** - **[Open GSE316922 in GEO (non-melanoma-skin-cancer scRNA-seq, n=36)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE316922)** - **[Open GSE318638 in GEO (non-melanoma-skin-cancer scTCR-Seq, n=34)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE318638)** - **[Open GSE292589 in GEO (Type-I-IFN-IPF single-cell + spatial, n=4)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE292589)** - **[Track biomni/Biomni-R0-32B-Preview on HuggingFace (now 5605 downloads)](https://huggingface.co/biomni/Biomni-R0-32B-Preview)** - **[Track NEW snap-stanford/humanlm-opinion on HuggingFace](https://huggingface.co/snap-stanford/humanlm-opinion)** - **[Read Boltz-1 trunk-diffusion boundary arXiv preprint](http://arxiv.org/abs/2608.11475v1)** - **[Read UMA-Inverse ligand-conditioned protein inverse-folding arXiv preprint](http://arxiv.org/abs/2607.07866v1)** - **[Read PairSAE mechanistic interpretability arXiv preprint](http://arxiv.org/abs/2606.27440v1)** - **[Read enzyme specificity benchmark arXiv preprint](http://arxiv.org/abs/2607.05084v1)** - **[Read deterministic viral-sequence-data access arXiv preprint](http://arxiv.org/abs/2606.06749v1)** - **[Request longevity + perivascular-niche + NMSC-immunotherapy + IPF-Type-I-IFN brief](https://brownbio.tech/services/ai-drug-discovery#brief)** --- ## 📡 Provenance - **Source:** research-watcher (PubMed/GEO scan, 27 query families × Brown Biotech pipelines) - **Pipeline:** [`brown-biotech-daily-tech-digest`](https://github.com/ohbryt/brown-biotech-platform) — 06:00 KST cron - **Generated:** 2026-08-18 06:09 KST - **Repo:** `ohbryt/brown-biotech-platform` --- _Auto-published by `brown_biotech_research_digest_publisher.py` · [brownbio.tech](https://brownbio.tech) · Decision-ready research, daily._
Brown Biotech Research Digest — 2026-08-18
PubMed/GEO scan · research-watcher · 06:00 KST