> 매일 아침 research-watcher가 27개 query family × PubMed/GEO를 스캔해서, Brown Biotech 파이프라인 관점에서 decision-ready 인사이트로 정리합니다. 매일 06:00 KST 자동 생성. **Category focus:** Bioinformatics & Multi-Omics **Published:** 2026-07-30 06:07 KST **Entry ID:** 56 **Tags:** #gse330351 #fth1 #ferritin #iron-homeostasis #fibroblast-activation #myofibroblast #cardiac-fibrosis #myocardial-infarction #spatial-transcriptomics #single-cell-rna-seq #gse319338 #glioblastoma --- ## 🔬 Today's Top Findings ### 1. Ferritin-iron control of fibroblast activation after myocardial infarction (GSE330351) ### 2. Perturb-seq maps MEK/SHP2 resistance modules in glioblastoma (GSE319338) ### 3. Ovarian single-cell atlas resolves senescent-cell accumulation across estropause (GSE267729) ## 📋 Synthesis The 2026-07-30 06:00 KST research-watcher scan completed successfully with 105 hits across 27 query families. Three actionable signals survived the peptide / AI-agent-infrastructure / longevity / cost gate, and all three are NOVEL versus yesterday's retained id:51-id:55 digest window. (1) Anti-fibrotic remodeling: GSE330351 integrates cross-species, spatial, single-cell, and functional data to position ferritin heavy chain FTH1 as a state regulator of inflammatory fibroblasts versus extracellular-matrix-producing myofibroblasts after myocardial infarction; ferritin depletion expands the labile iron pool and increases profibrotic expression. (2) Refractory cancer and AI-ready perturbation data: GSE319338 combines scRNA-seq, genome-wide CRISPRi, and a 39-target Perturb-seq panel under MEK or SHP2 inhibition to separate shared Ras/RAF/MEK dependencies from SHP2-specific SRC-family, GSK3B, and SMAD resistance modules in glioblastoma. (3) Longevity and senolytics: GSE267729 provides a staged mouse ovarian-aging atlas plus beta-galactosidase-high senescent-cell profiles, linking irregular estropausal cycling to transcriptional noise, OXPHOS/proteostasis disruption, Cdkn1a induction, and SASP accumulation. NCBI GEO supplied full study summaries and designs, but none of the three records had a linked PMID or DOI at scan time; source accession links are therefore the primary citations. --- ## 🎯 Highlights ### 1. Signal 1 \u2014 Bioinformatics & Multi-Omics / anti-fibrotic remodeling: GSE330351 (watcher score 7, n=9, pdat 2026/06/30) integrates spatial transcriptomics, scRNA-seq, bulk RNA-seq, trajectory analysis, and functional fibroblast studies. FTH1 is enriched in early/inflammatory fibroblast states, declines during transition toward ECM-producing myofibroblasts, and ferritin depletion expands labile iron while increasing profibrotic genes. Four-axis score: peptide 0/3, AI-agent infrastructure 2/3, longevity 1/3, cost/ease 3/3 = 6/12. Why it matters for BB: this is a tractable iron-homeostasis mechanism and open multi-omic benchmark for anti-fibrotic target nomination, state-transition scoring, and cross-organ validation against IPF/MASH fibroblast programs. Citation: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE330351; no linked PMID/DOI at scan time. ### 2. Signal 2 \u2014 AI Drug Discovery / refractory cancer: GSE319338 (watcher score 6, n=13, pdat 2026/07/27) profiles glioblastoma response to selumetinib (MEK) and RMC-4550 (SHP2) with scRNA-seq, genome-wide CRISPRi, and 39-target Perturb-seq. It separates shared Ras/RAF/MEK sensitivity genes from SHP2-specific SRC-family kinase, GSK3B, and SMAD modules and exposes discrete resistance-state clusters. Four-axis score: peptide 0/3, AI-agent infrastructure 3/3, longevity 0/3, cost/ease 3/3 = 6/12. Why it matters for BB: this is directly ingestible perturbation-response data for combination ranking, resistance-mechanism graphs, and foundation-model evaluation in refractory cancer without funding a new screen. Citation: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319338; no linked PMID/DOI at scan time. ### 3. Signal 3 \u2014 Longevity & Senolytics: GSE267729 (watcher score 4, n=18, pdat 2026/07/01) maps young, peri-estropausal, and post-estropausal mouse ovaries and separately profiles senescence-associated beta-galactosidase-high ovarian cells. Irregularly cycling peri-estropausal ovaries show accelerated-aging features, increased transcriptional noise, disrupted OXPHOS/proteostasis, granulosa-cell hormone dysregulation, Cdkn1a induction, and SASP accumulation. Four-axis score: peptide 0/3, AI-agent infrastructure 2/3, longevity 3/3, cost/ease 3/3 = 8/12. Why it matters for BB: the atlas supplies a stage-resolved senotype reference for biomarker selection and senolytic hypothesis testing, while explicitly separating reproductive stage from chronological age. Citation: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE267729; no linked PMID/DOI at scan time. ### 4. Decision gate and next action \u2014 all three accessions are absent from id:51-id:55, so novelty is 3/3. Combined four-axis score is 20/36, with longevity relevance led by GSE267729 and immediate translational leverage led by GSE330351/GSE319338. Recommended BB move: ingest the raw matrices; map GSE330351 FTH1-high-to-myofibroblast trajectories against BB IPF/MASH fibroblast signatures; use GSE319338 perturbation labels to benchmark resistance-aware target ranking; and derive a compact Cdkn1a/SASP/OXPHOS senotype panel from GSE267729 before commissioning any wet-lab follow-up. --- ## 💼 Next Steps - **[Open GSE330351 in GEO (ferritin / fibroblast remodeling)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE330351)** - **[Open GSE319338 in GEO (GBM MEK/SHP2 Perturb-seq)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319338)** - **[Open GSE267729 in GEO (ovarian aging / senescent cells)](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE267729)** - **[Request anti-fibrotic + refractory-cancer + longevity brief](https://brownbio.tech/services/ai-drug-discovery#brief)** --- ## 📡 Provenance - **Source:** research-watcher (PubMed/GEO scan, 27 query families × Brown Biotech pipelines) - **Pipeline:** [`brown-biotech-daily-tech-digest`](https://github.com/ohbryt/brown-biotech-platform) — 06:00 KST cron - **Generated:** 2026-07-30 06:07 KST - **Repo:** `ohbryt/brown-biotech-platform` --- _Auto-published by `brown_biotech_research_digest_publisher.py` · [brownbio.tech](https://brownbio.tech) · Decision-ready research, daily._
Brown Biotech Research Digest — 2026-07-30
PubMed/GEO scan · research-watcher · 06:00 KST