> 매일 아침 research-watcher가 27개 query family × PubMed/GEO를 스캔해서, Brown Biotech 파이프라인 관점에서 decision-ready 인사이트로 정리합니다. 매일 06:00 KST 자동 생성. **Category focus:** Bioinformatics & Multi-Omics **Published:** 2026-07-26 06:03 KST **Entry ID:** 53 **Tags:** #research-watcher #novel signal #open science #multi-omics #Brown Biotech #GSE328275 #Single-cell #RNA #sequencing #CD45+ #immune #cells --- ## 🔬 Today's Top Findings ### 1. Single-cell RNA sequencing of CD45+ immune cells across primary tumor, sentinel tumor-draining lymph node, and axillary lymph node in treatment-naive triple-negative breast cancer (GSE328275, score 9, n=not stated, Homo sapiens, pdat 2026/06/27) ### 2. Systematic benchmarking of imaging spatial transcriptomics platforms in FFPE tissues - Xenium Data (GSE308148, score 9, n=not stated, Homo sapiens, pdat 2025/10/03) ### 3. Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets (GSE277080, score 9, n=not stated, Homo sapiens, pdat 2025/07/28) ## 📋 Synthesis Fresh 2026-07-26 watcher scan produced 105 hits across 27 queries. This entry promotes three previously unmentioned accessions after accession-level novelty screening against yesterday and the other retained digests. GSE328275: Single-cell RNA sequencing of CD45+ immune cells across primary tumor, sentinel tumor-draining lymph node, and axillary lymph node in treatment-naive triple-negative breast cancer; GSE308148: Systematic benchmarking of imaging spatial transcriptomics platforms in FFPE tissues - Xenium Data; GSE277080: Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets. Why it matters for Brown Biotech: the combined set expands reusable evidence for multi-omics briefs, translational target prioritization, and client-ready research synthesis; each signal should be validated at source before downstream claims or model training. --- ## 🎯 Highlights ### 1. 1. GSE328275 — Single-cell RNA sequencing of CD45+ immune cells across primary tumor, sentinel tumor-draining lymph node, and axillary lymph node in treatment-naive triple-negative breast cancer; watcher score 9, sample count not stated, pdat 2026/06/27. Novel versus all five retained digest entries and suitable for BB evidence triage. ### 2. 2. GSE308148 — Systematic benchmarking of imaging spatial transcriptomics platforms in FFPE tissues - Xenium Data; watcher score 9, sample count not stated, pdat 2025/10/03. Novel versus all five retained digest entries and suitable for BB evidence triage. ### 3. 3. GSE277080 — Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets; watcher score 9, sample count not stated, pdat 2025/07/28. Novel versus all five retained digest entries and suitable for BB evidence triage. --- ## 💼 Next Steps - **[Open GSE328275 in GEO](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328275)** - **[Open GSE308148 in GEO](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE308148)** - **[Open GSE277080 in GEO](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE277080)** - **[Request a multi-omics brief](https://brownbio.tech/multiomics#brief)** --- ## 📡 Provenance - **Source:** research-watcher (PubMed/GEO scan, 27 query families × Brown Biotech pipelines) - **Pipeline:** [`brown-biotech-daily-tech-digest`](https://github.com/ohbryt/brown-biotech-platform) — 06:00 KST cron - **Generated:** 2026-07-26 06:03 KST - **Repo:** `ohbryt/brown-biotech-platform` --- _Auto-published by `brown_biotech_research_digest_publisher.py` · [brownbio.tech](https://brownbio.tech) · Decision-ready research, daily._
Brown Biotech Research Digest — 2026-07-26
PubMed/GEO scan · research-watcher · 06:00 KST