> 매일 아침 research-watcher가 27개 query family × PubMed/GEO를 스캔해서, Brown Biotech 파이프라인 관점에서 decision-ready 인사이트로 정리합니다. 매일 06:00 KST 자동 생성. **Category focus:** AI Drug Discovery **Published:** 2026-07-22 06:17 KST **Entry ID:** 50 **Tags:** #ZFP36L2 #ZFP36 family #TIS11D #BRF2 #zinc finger protein 36-like 2 #AU-rich element #ARE-binding protein #RNA-binding protein #RBP #post-transcriptional regulation #mRNA decay #mRNA deadenylation --- ## 🔬 Today's Top Findings ### 1. ZFP36L2 orchestrates stress-adaptive plasticity in intestinal regeneration and colorectal cancer metastasis (GSE336781, score 6, n=93, Homo sapiens, expression profiling by high throughput sequencing, pdat 2026/07/20 = 2 days ago, the FRESHEST score-6 RNA-binding-protein / post-transcriptional-regulation / intestinal-regeneration / colorectal-cancer-metastasis hit in the 2026-07-22 scan and the largest n=93 RBOME-style dataset surfaced this cycle) ### 2. Subtype-Specific Dependencies and Drug Vulnerabilities Enable Precision Therapeutics in Head and Neck Cancer (GSE311507, score 9, n=16, Homo sapiens, expression profiling by high throughput sequencing, pdat 2026/06/01 = 51 days ago, the FRESHEST score-9 head-and-neck-cancer precision-oncology / CRISPR-style dependency-mapping hit in the scan and the only score-9 HNC vulnerability dataset surfaced this cycle) ### 3. Ferritin-mediated iron homeostasis regulates fibroblast activation and shapes post-infarction cardiac remodeling (GSE330351, score 7, n=9, Mus musculus, expression profiling by high throughput sequencing, pdat 2026/06/30 = 22 days ago, the FRESHEST score-7 ferritin / iron-handling / ferroptosis-axis / post-MI-cardiac-fibrosis single-cell + spatial hit in the scan) ## 📋 Synthesis The 2026-07-22 06:00 KST research-watcher scan completed successfully with 105 hits across 27 queries. Three actionable signals survived the peptide / AI-infrastructure / longevity / cost screen, and all three are NOVEL versus yesterday's id:49 digest (GSE337521 BTKi+anti-CD20 MZL + GSE262166 Claudin-1 CCA + GSE312779 DMD steroid multiomics) and absent from the retained id:46-id:49 window. (1) Refractory GI cancer + post-transcriptional regulation: GSE336781 deposits a freshly released (pdat 2026/07/20) n=93 RNA-seq dataset nominating ZFP36L2 (zinc finger protein 36-like 2, also known as TIS11D / BRF2, an AU-rich-element-binding RNA-binding protein of the ZFP36 family that drives 3'-UTR mRNA deadenylation and decay of cytokine + immediate-early + growth-factor transcripts) as a stress-adaptive regulator of intestinal regeneration and colorectal cancer metastasis. The dataset's n=93 design is unusually large for a post-transcriptional-regulation therapeutic entry and supports both regenerative-biology and metastasis-suppressor angles for the BB refractory-CRC lane. Caveat: raw-file availability is listed as 'maybe' in the watcher output, so any chemistry claim must await supplementary file confirmation. (2) Refractory HNC + precision oncology: GSE311507 is a score-9, perturbation-positive, n=16 head-and-neck-cancer dependency-mapping dataset that connects subtype-specific lineage dependencies to drug vulnerability. HNC remains an underrepresented refractory-cancer lane in the retained id:46-id:49 window (only CRC + CCA + MZL + DMD-adjacent + tRCC + NSD2-MM + TNBC + IPF were featured) and a score-9 perturbation dataset gives the BB precision-oncology + AI-drug-discovery lane a tractable nominated-target slate for HNC subtype stratification. (3) Fibrosis + longevity + cardiac aging: GSE330351 is a score-7, single-cell + spatial, n=9 dataset nominating ferritin-mediated iron homeostasis as a regulator of fibroblast activation in post-infarction cardiac remodeling. The ferritin/iron-handling / ferroptosis axis is a fresh anti-fibrotic angle not covered in the IPF-T-cell-multiomic (id:45), IPF-IFN-myeloid (id:46), TGF-beta-SMAD/YAP-ChIP-seq (id:48), or DeepSAS-senotype (id:48) entries, and the cardiac-aging angle complements yesterday's DMD-steroid multiomics (id:49) and earlier exercise-trained-muscle-aging (id:47) datasets with a different tissue (heart vs skeletal muscle) and different mechanism (iron handling vs contractile / OXPHOS). Why this matters for Brown Biotech: together these three datasets define a reusable pipeline from post-transcriptional target nomination (GSE336781), through subtype-specific dependency mapping (GSE311507), to iron-handling-driven anti-fibrotic nomination (GSE330351) for refractory-cancer + fibrosis + longevity programs. --- ## 🎯 Highlights ### 1. Refractory GI cancer + post-transcriptional regulation — GSE336781 (score 6, n=93 Homo sapiens expression profiling by high throughput sequencing, pdat 2026/07/20 = 2 days ago, raw_file_availability 'maybe') nominates ZFP36L2 (zinc finger protein 36-like 2, TIS11D, BRF2, an AU-rich-element-binding RNA-binding protein of the ZFP36 family that drives 3'-UTR mRNA deadenylation and decay of cytokine + immediate-early + growth-factor transcripts including TNF-alpha, IL-2, IL-3, GM-CSF, c-Fos, c-Myc, COX-2, and VEGF) as a stress-adaptive regulator of intestinal regeneration and colorectal cancer metastasis. Why it matters for BB: ZFP36 family members are validated post-transcriptional tumor-suppressor candidates across multiple cancer lineages (ZFP36 / TTP loss drives MYC-driven lymphomas and pancreatic-cancer chemoresistance; ZFP36L1 loss drives B-cell and T-cell malignancies; ZFP36L2 mutations are enriched in hematologic malignancies and colorectal neoplasia), and the n=93 RNA-seq design is unusually large for a ZFP36-family therapeutic entry. Caveat: raw files are 'maybe' in the watcher — supplementary file confirmation is required before any chemistry claim. Source: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE336781. GEO lists no linked PMID or DOI as of scan time. ### 2. Refractory HNC + precision oncology — GSE311507 (score 9, n=16 Homo sapiens expression profiling by high throughput sequencing, pdat 2026/06/01 = 51 days ago, raw_file_availability 'yes') is the only score-9 head-and-neck-cancer precision-oncology / CRISPR-style dependency-mapping hit in the entire 2026-07-22 scan and a direct AI-drug-discovery + refractory-cancer + target-nomination input for the BB precision-oncology lane. Head and neck cancer (HNC, ~900,000 new cases/year globally, ~450,000 deaths/year, 6th-most-common cancer worldwide) is dominated by head and neck squamous cell carcinoma (HNSCC, ~90% of HNC) with two clinically actionable axes — HPV-positive vs HPV-negative disease — and limited targeted-therapy options beyond cetuximab (anti-EGFR mAb) + pembrolizumab/nivolumab (anti-PD-1) + a small subset of FGFR inhibitors; the n=16 perturbation design (likely paired subtype-stratified dependency-mapping across HPV-positive vs HPV-negative HNSCC lines with or without lineage-dependency stratification) delivers direct nomination of subtype-specific dependencies that can be matched against existing clinical-stage targeted-therapy candidates. Why it matters for BB: HNC is underrepresented in the retained id:46-id:49 window (only CRC + CCA + MZL + DMD-adjacent + tRCC + NSD2-MM + TNBC + IPF were featured), and a score-9 perturbation dataset is a direct AI-drug-discovery nomination input. Source: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE311507. GEO lists no linked PMID or DOI as of scan time. ### 3. Fibrosis + longevity + cardiac aging — GSE330351 (score 7, n=9 Mus musculus expression profiling, pdat 2026/06/30 = 22 days ago, single-cell + spatial pairing, raw_file_availability 'yes') is the FRESHEST score-7 ferritin / iron-handling / ferroptosis-axis / post-MI-cardiac-fibrosis single-cell + spatial hit in the entire 2026-07-22 scan and a direct bioinformatics + fibrosis + longevity + cardiac-aging input for the BB anti-fibrotic + iron-handling lane. Ferritin (a 24-subunit nanocage protein composed of FTH1 / ferritin heavy chain with ferroxidase activity + FTL / ferritin light chain with nucleation activity) is the canonical cellular iron-storage protein and the gatekeeper of the labile iron pool (LIP); FTH1 loss or ferritinophagy (NCOA4-mediated ferritin degradation) elevates LIP, drives Fenton-chemistry reactive oxygen species (ROS) generation, and primes cells for ferroptosis (an iron-dependent regulated necrosis driven by lipid peroxidation and executed via GPX4 inactivation + ACSL4-driven lipid peroxide accumulation); the post-myocardial-infarction (post-MI) cardiac-remodeling context couples ferroptosis sensitivity to fibroblast activation and cardiac-fibrosis progression, and a single-cell + spatial mouse dataset at n=9 with raw files is a tractable input for both target-nomination (FTH1 stabilizers, NCOA4 inhibitors, GPX4 inducers) and biomarker-stratification (ferritin-heavy-chain expression, lipid-peroxide load) work. Why it matters for BB: this is a fresh iron-handling anti-fibrotic angle that complements the IPF T-cell-multiomic (id:45), IPF IFN-I-myeloid (id:46), TGF-beta-SMAD/YAP-ChIP-seq (id:48), and DeepSAS-senotype (id:48) entries; the cardiac-aging axis also complements yesterday's DMD-steroid multiomics (id:49) and earlier exercise-trained-muscle-aging (id:47) with a different tissue (heart vs skeletal muscle) and different mechanism (iron handling vs contractile / OXPHOS). Source: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE330351. GEO lists no linked PMID or DOI as of scan time. ### 4. Four-axis decision gate — ZFP36L2 / CRC metastasis: peptide 0/3, AI infrastructure 2/3, longevity 1/3 (intestinal regeneration overlaps tissue-rejuvenation), low-cost/ease 2/3 (n=93 but raw files 'maybe'), translational fit 3/3 = 8/15; HNC subtype vulnerabilities: peptide 0/3, AI infrastructure 3/3 (perturbation + score 9), longevity 0/3, low-cost/ease 2/3, translational fit 3/3 = 8/15; Ferritin / post-MI cardiac fibrosis: peptide 0/3, AI infrastructure 1/3, longevity 2/3 (cardiac aging + iron-driven inflammaging axis), low-cost/ease 3/3 (raw files available), translational fit 2/3 = 8/15. Combined 24/45. All three are first-time primary features today and absent from id:46-id:49. Next action: reproduce ZFP36L2 stress-adaptive plasticity calls across external CRC cohorts and confirm raw-file availability on GSE336781 before chemistry claims; benchmark HNC subtype-specific dependencies against existing DepMap HNC lines; intersect ferritin / iron-handling signatures with CTHRC1+ fibroblast regulons from id:48 DeepSAS and with GSE292589 (id:46) IFN-I myeloid signatures to define a ferroptosis-vs-myocardial-fibrosis axis. --- ## 💼 Next Steps - **[View ZFP36L2 / CRC intestinal regeneration dataset](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE336781)** - **[View HNC subtype-specific dependency dataset](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE311507)** - **[View ferritin / post-MI cardiac fibroblast dataset](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE330351)** - **[Request integrated refractory-cancer + fibrosis brief](https://brownbio.tech/services/ai-drug-discovery#brief)** --- ## 📡 Provenance - **Source:** research-watcher (PubMed/GEO scan, 27 query families × Brown Biotech pipelines) - **Pipeline:** [`brown-biotech-daily-tech-digest`](https://github.com/ohbryt/brown-biotech-platform) — 06:00 KST cron - **Generated:** 2026-07-22 06:17 KST - **Repo:** `ohbryt/brown-biotech-platform` --- _Auto-published by `brown_biotech_research_digest_publisher.py` · [brownbio.tech](https://brownbio.tech) · Decision-ready research, daily._
Brown Biotech Research Digest — 2026-07-22
PubMed/GEO scan · research-watcher · 06:00 KST