> 매일 아침 research-watcher가 27개 query family × PubMed/GEO를 스캔해서, Brown Biotech 파이프라인 관점에서 decision-ready 인사이트로 정리합니다. 매일 06:00 KST 자동 생성. **Category focus:** AI Drug Discovery **Published:** 2026-07-15 06:18 KST **Entry ID:** 43 **Tags:** #ferroptosis #PGK1 #SLC7A11 #FP-01 #competing peptide #GSE317428 #SLC40A1 #tumor-associated macrophage #PD-1 #immunotherapy resistance #GSE302068 #PIEZO1 --- ## 🔬 Today's Top Findings ### 1. PGK1–SLC7A11 interface yields a competing peptide ferroptosis strategy (GSE317428, score 6, n=6, pdat 2026/07/12) ### 2. SLC40A1+ macrophages link ferroptosis resistance to PD-1 nonresponse (GSE302068, score 6, n=9) ### 3. Endothelial PIEZO1–CAPN2–STAT3–IL-33 signaling drives pulmonary fibrosis (GSE314943, score 4, n=18) ## 📋 Synthesis The 2026-07-15 06:00 KST watcher scan returned 106 hits. Three actionable signals were selected after a four-axis screen (peptide fit, AI-drug-discovery value, longevity/fibrosis relevance, and analysis cost). All three are novel versus yesterday's id:42 digest and absent from the retained id:39-id:42 window. Together they connect Brown Biotech's peptide and refractory-cancer lanes to a low-cost fibrosis target-validation path: disrupt a protein interface to trigger ferroptosis, stratify immunotherapy resistance by macrophage state, and test a mechanosensitive endothelial axis in pulmonary fibrosis. --- ## 🎯 Highlights ### 1. Peptide / AI drug discovery — GSE317428 reports PGK1 as a non-catalytic ferroptosis gatekeeper: it stabilizes SLC7A11, preserves glutathione/redox balance, and supports tumor growth independently of glycolytic kinase activity. A designed competing peptide, SLC7A11₄₇₁–₅₀₁ (FP-01), disrupts the PGK1–SLC7A11 interface, depletes SLC7A11/GSH, and suppresses tumor progression in vivo. Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE317428. ### 2. Refractory-cancer / immunotherapy — GSE302068 profiles SLC40A1/ferroportin perturbation in THP-1-derived macrophages and supports a model in which metabolically reprogrammed SLC40A1+ tumor-associated macrophages are ferroptosis-resistant, immunosuppressive, and enriched in patients who fail PD-1 blockade. Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE302068. ### 3. Fibrosis / target nomination — GSE314943 identifies an endothelial PIEZO1–CAPN2–STAT3–IL-33 axis in pulmonary fibrosis; endothelial-specific Piezo1 loss attenuated bleomycin fibrosis in the reported model. The 18-sample multi-omics design is a tractable low-cost re-analysis candidate for Brown Biotech's anti-fibrotic/IPF lane, but the mouse model requires human validation before therapeutic claims. Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE314943. ### 4. Cost and next action — all three are public GEO datasets with raw or semi-raw files available; GSE317428 is the freshest (pdat 2026/07/12) and most directly peptide-actionable, while GSE302068 and GSE314943 are smaller perturbation datasets suitable for QC-first triage. Run QC, reproduce the ferroptosis/immune-state contrasts, then prioritize FP-01 interface optimization and PIEZO1-axis cross-cohort validation; no DOI or PMID is listed for these GEO records. --- ## 💼 Next Steps - **[Request peptide / PGK1–SLC7A11 FP-01 brief](https://brownbio.tech/services/peptide#brief)** - **[Request refractory-cancer / macrophage ferroptosis brief](https://brownbio.tech/multiomics#brief)** - **[Request fibrosis / PIEZO1–IL-33 target brief](https://brownbio.tech/multiomics#brief)** - **[Request AI drug discovery / interface-optimization brief](https://brownbio.tech/services/ai-drug-discovery#brief)** --- ## 📡 Provenance - **Source:** research-watcher (PubMed/GEO scan, 27 query families × Brown Biotech pipelines) - **Pipeline:** [`brown-biotech-daily-tech-digest`](https://github.com/ohbryt/brown-biotech-platform) — 06:00 KST cron - **Generated:** 2026-07-15 06:18 KST - **Repo:** `ohbryt/brown-biotech-platform` --- _Auto-published by `brown_biotech_research_digest_publisher.py` · [brownbio.tech](https://brownbio.tech) · Decision-ready research, daily._
Brown Biotech Research Digest — 2026-07-15
PubMed/GEO scan · research-watcher · 06:00 KST