> 매일 아침 research-watcher가 27개 query family × PubMed/GEO를 스캔해서, Brown Biotech 파이프라인 관점에서 decision-ready 인사이트로 정리합니다. 매일 06:00 KST 자동 생성. **Category focus:** Bioinformatics & Multi-Omics **Published:** 2026-07-02 06:07 KST **Entry ID:** 30 **Tags:** #lymph node metastasis #sequential lymph node metastasis #spatio-temporal mapping #spatio-temporal #immune cell dynamics #metastatic progression #single-cell + spatial #spatial transcriptomics #TNBC #triple-negative breast cancer #tumor immunology #immuno-oncology --- ## 🔬 Today's Top Findings ### 1. Spatio-temporal mapping of immune cell dynamics during human sequential lymph node metastasis (GSE328422, score 9, n=6, Homo sapiens, pdat 2026/06/27) ### 2. Dual regulation of CXCR6+CD8+ T cells drives immune exhaustion in the progression of prostate cancer [PB-Cre ### 3. Pten knockout and WT] (GSE313701, score 7, n=6, Mus musculus, pdat 2026/06/30) ### 4. Ferritin-mediated iron homeostasis regulates fibroblast activation and shapes post-infarction cardiac remodeling (GSE330351, score 7, n=9, Mus musculus, pdat 2026/06/30) ## 📋 Synthesis Three freshly deposited hits spanning bioinformatics / spatial immuno-oncology (spatio-temporal mapping of immune cell dynamics during human sequential lymph node metastasis — the gold-standard design for understanding how immune cell composition evolves across sequential lymph node stations during metastatic progression, promoted from below-the-fold companion in id:29 to primary feature), AI drug discovery / tumor immunology + prostate cancer IO (dual regulation of CXCR6+CD8+ T cells driving immune exhaustion in prostate cancer progression via PB-Cre; Pten knockout perturbation — the cleanest possible dissection of T-cell exhaustion in the prostate tumor microenvironment and a direct input for Brown Biotech's AI drug discovery / tumor immunology lane where CXCR6 is an active T-cell-trafficking therapeutic target for solid-tumor IO), and bioinformatics / cardio-fibrosis + iron-metabolism (ferritin-mediated iron homeostasis regulating fibroblast activation and shaping post-infarction cardiac remodeling — a clean single-cell + spatial dissection linking iron metabolism to cardiac fibroblast biology in myocardial infarction, the leading cause of heart failure), drawn from the research-watcher's 2026-07-02 scan (collected_at 2026-07-01T21:01–21:02 UTC = 2026-07-02 06:01–06:02 KST; 106 hits ingested in the new 2026-07-02/ output directory): (1) Spatio-temporal mapping of immune cell dynamics during human sequential lymph node metastasis (GSE328422, score 9, n=6, pdat 2026/06/27, single-cell + spatial, Homo sapiens, clean license, raw files available, suppfile H5/PARQUET/RDS/TIFF) — a freshly deposited (pdat = 5 days ago) score-9 spatio-temporal single-cell + spatial atlas of immune cell dynamics during human sequential lymph node metastasis, the gold-standard design for dissecting how immune cell composition evolves across sequential lymph node stations (sentinel → downstream) during metastatic progression; the single-cell + spatial pairing on matched sequential-LN samples delivers the maximum-utility immune-dissection design for understanding metastatic immune-escape trajectories at single-cell resolution and is a direct bioinformatics / spatial-immunology input for Brown Biotech's TNBC lymph-node-metastasis lane (axillary LN status remains the single most important prognostic factor in TNBC and a major determinant of treatment intensification); pairs directly with the GSE328275 treatment-naive TNBC CD45+ three-region immune atlas (id:29, primary yesterday) on a shared TNBC lymph-node-metastasis thread and is today promoted from below-the-fold companion to primary feature; the n=6 cohort with raw H5/PARQUET/RDS/TIFF files enables direct reanalysis. (2) Dual regulation of CXCR6+CD8+ T cells drives immune exhaustion in the progression of prostate cancer [PB-Cre; Pten knockout and WT] (GSE313701, score 7, n=6, pdat 2026/06/30, single-cell, Mus musculus, clean license, raw files available, suppfile TXT) — a freshly deposited (pdat = 2 days ago) score-7 single-cell dissection of CXCR6+CD8+ T-cell dual regulation driving immune exhaustion in prostate cancer progression using the PB-Cre; Pten conditional knockout model (the gold-standard prostate-specific Pten-loss model that recapitulates the canonical PI3K/AKT pathway activation seen in ~40% of primary prostate cancers and drives progression to invasive disease); CXCR6 is an active T-cell-trafficking therapeutic target for solid-tumor IO (CXCR6+ tissue-resident memory T cells are essential for tumor-infiltrating CD8+ T-cell responses and CXCR6 axis blockade is being explored in IO combinations); the cleanest possible dissection of T-cell exhaustion in the prostate tumor microenvironment and a direct AI drug discovery / tumor-immunology input for Brown Biotech's prostate cancer IO lane; pairs with the GSE311507 HNSCC subtype-specific dependency atlas (id:25, id:28) on a shared solid-tumor IO thread. (3) Ferritin-mediated iron homeostasis regulates fibroblast activation and shapes post-infarction cardiac remodeling (GSE330351, score 7, n=9, pdat 2026/06/30, single-cell + spatial, Mus musculus, clean license, raw files available, suppfile CSV) — a freshly deposited (pdat = 2 days ago) score-7 single-cell + spatial dissection of ferritin-mediated iron homeostasis regulating fibroblast activation and shaping post-infarction cardiac remodeling; ferritin (the canonical iron-storage protein and the central regulator of cellular iron homeostasis) is an emerging anti-fibrotic target (iron overload is a well-established driver of cardiac fibrosis and post-MI remodeling, and ferritin heavy-chain [FTH1] induction is a key cellular response to iron excess); the cleanest possible dissection linking iron metabolism to cardiac fibroblast biology in myocardial infarction (the leading cause of heart failure and a major cause of morbidity/mortality globally) and a direct bioinformatics / cardio-fibrosis + iron-metabolism input for Brown Biotech's anti-fibrotic cardio lane (pairs with the GSE315246/47/48 FAP-directed atherosclerosis bundle [id:23] on shared cardiovascular-fibrosis biology, and with the GSE331144 CTHRC1+ lung-fibroblast fibrogenic-hubs atlas [id:26, id:28] on shared fibroblast-niche anti-fibrotic biology); the n=9 cohort with single-cell + spatial pairing delivers maximum cross-modality utility. --- ## 🎯 Highlights ### 1. Spatio-temporal mapping of immune cell dynamics during human sequential lymph node metastasis (GSE328422, score 9, n=6, pdat 2026/06/27, single-cell + spatial, Homo sapiens, clean license, raw files available, suppfile H5/PARQUET/RDS/TIFF): freshly deposited (pdat = 5 days ago) score-9 spatio-temporal single-cell + spatial atlas of immune cell dynamics during human sequential lymph node metastasis — the gold-standard design for dissecting how immune cell composition evolves across sequential lymph node stations (sentinel → downstream) during metastatic progression; the single-cell + spatial pairing on matched sequential-LN samples delivers the maximum-utility immune-dissection design for understanding metastatic immune-escape trajectories at single-cell resolution and a direct bioinformatics / spatial-immunology input for Brown Biotech's TNBC lymph-node-metastasis lane (axillary LN status remains the single most important prognostic factor in TNBC and a major determinant of treatment intensification); promoted from below-the-fold companion in id:29 to primary feature today; the n=6 cohort with raw H5/PARQUET/RDS/TIFF files enables direct reanalysis; pairs with the GSE328275 treatment-naive TNBC CD45+ three-region immune atlas (id:29, primary yesterday) on a shared TNBC lymph-node-metastasis thread. ### 2. Dual regulation of CXCR6+CD8+ T cells drives immune exhaustion in the progression of prostate cancer [PB-Cre; Pten knockout and WT] (GSE313701, score 7, n=6, pdat 2026/06/30, single-cell, Mus musculus, clean license, raw files available, suppfile TXT): freshly deposited (pdat = 2 days ago) score-7 single-cell dissection of CXCR6+CD8+ T-cell dual regulation driving immune exhaustion in prostate cancer progression using the PB-Cre; Pten conditional knockout model (the gold-standard prostate-specific Pten-loss model that recapitulates canonical PI3K/AKT pathway activation seen in ~40% of primary prostate cancers and drives progression to invasive disease) — CXCR6 is an active T-cell-trafficking therapeutic target for solid-tumor IO (CXCR6+ tissue-resident memory T cells are essential for tumor-infiltrating CD8+ T-cell responses and CXCR6 axis modulation is being explored in IO combinations); the cleanest possible dissection of T-cell exhaustion in the prostate tumor microenvironment and a direct AI drug discovery / tumor-immunology input for Brown Biotech's prostate cancer IO lane; pairs with the GSE311507 HNSCC subtype-specific dependency atlas (id:25, id:28) on a shared solid-tumor IO thread; first primary-feature promotion today. ### 3. Ferritin-mediated iron homeostasis regulates fibroblast activation and shapes post-infarction cardiac remodeling (GSE330351, score 7, n=9, pdat 2026/06/30, single-cell + spatial, Mus musculus, clean license, raw files available, suppfile CSV): freshly deposited (pdat = 2 days ago) score-7 single-cell + spatial dissection of ferritin-mediated iron homeostasis regulating fibroblast activation and shaping post-infarction cardiac remodeling — ferritin (the canonical iron-storage protein and central regulator of cellular iron homeostasis) is an emerging anti-fibrotic target (iron overload is a well-established driver of cardiac fibrosis and post-MI remodeling, and ferritin heavy-chain [FTH1] induction is a key cellular response to iron excess); the cleanest possible dissection linking iron metabolism to cardiac fibroblast biology in myocardial infarction (the leading cause of heart failure globally) and a direct bioinformatics / cardio-fibrosis + iron-metabolism input for Brown Biotech's anti-fibrotic cardio lane; pairs with the GSE315246/47/48 FAP-directed atherosclerosis bundle (id:23) on shared cardiovascular-fibrosis biology and with the GSE331144 CTHRC1+ lung-fibroblast fibrogenic-hubs atlas (id:26, id:28) on shared fibroblast-niche anti-fibrotic biology; the n=9 cohort with single-cell + spatial pairing delivers maximum cross-modality utility; first primary-feature promotion today. ### 4. Combined signal: bioinformatics / spatial immuno-oncology (spatio-temporal mapping of immune cell dynamics during human sequential lymph node metastasis — promoted from below-the-fold in id:29 to primary feature today) + AI drug discovery / prostate cancer IO (dual regulation of CXCR6+CD8+ T cells driving immune exhaustion via PB-Cre; Pten conditional knockout perturbation — a new solid-tumor IO target nomination) + bioinformatics / cardio-fibrosis + iron-metabolism (ferritin-mediated iron homeostasis regulating cardiac fibroblast activation post-MI — a new anti-fibrotic cardio target nomination) — three orthogonal modalities spanning 2 of 6 Brown Biotech coverage categories (bioinformatics + AI drug discovery), all clean-license GEO with raw files available and 2 of 3 freshly deposited within the last 2 days; the watcher's 2026-07-02 scan (collected_at 2026-07-01T21:01–21:02 UTC = 2026-07-02 06:01–06:02 KST) ran on its normal 06:00 KST cadence and emitted 106 hits across 27 queries; today's picks are scored 9/10 + 7/10 + 7/10, consistent with the post-id:26 rotation through the higher-score queue (id:25-id:29 each featured at least one score-9 dataset, while the new GSE313701 and GSE330351 are the strongest fresh score-7 entries not yet featured as primary picks); the HF channel also resurfaced the longevity-db/human-muscle-aging-atlas-snRNAseq dataset (score 4, cc-by-4.0) and the ProteinGym_v1 benchmarks (score 2, archive-only) — both reinforce the longevity / muscle-aging and protein-design / variant-effect-prediction threads but neither clears the immediate intake threshold today. --- ## 💼 Next Steps - **[Request bioinformatics / TNBC LN-metastasis brief](https://brownbio.tech/multiomics#brief)** - **[Request AI drug discovery / prostate CXCR6 IO brief](https://brownbio.tech/services/ai-drug-discovery#brief)** - **[Request bioinformatics / ferritin cardio-fibrosis brief](https://brownbio.tech/multiomics#brief)** - **[View biostatx service](https://brownbio.tech/services/biostatx)** --- ## 📡 Provenance - **Source:** research-watcher (PubMed/GEO scan, 27 query families × Brown Biotech pipelines) - **Pipeline:** [`brown-biotech-daily-tech-digest`](https://github.com/ohbryt/brown-biotech-platform) — 06:00 KST cron - **Generated:** 2026-07-02 06:07 KST - **Repo:** `ohbryt/brown-biotech-platform` --- _Auto-published by `brown_biotech_research_digest_publisher.py` · [brownbio.tech](https://brownbio.tech) · Decision-ready research, daily._
Brown Biotech Research Digest — 2026-07-02
PubMed/GEO scan · research-watcher · 06:00 KST