> 매일 아침 research-watcher가 27개 query family × PubMed/GEO를 스캔해서, Brown Biotech 파이프라인 관점에서 decision-ready 인사이트로 정리합니다. 매일 06:00 KST 자동 생성. **Category focus:** Bioinformatics & Multi-Omics **Published:** 2026-06-25 06:09 KST **Entry ID:** 23 **Tags:** #craniosynostosis #suture stem cell #suture biology #developmental biology #skeletal biology #spatiotemporal atlas #Visium HD #scRNA-Seq #single-cell + spatial #spatial transcriptomics #Mus musculus #mouse model --- ## 🔬 Today's Top Findings ### 1. Spatiotemporal single-cell atlas of suture stem cell dynamics in craniosynostosis (scRNA-Seq + Visium HD bundle, GSE303460/GSE303344, score 7, n=14+3, Mus musculus, pdat 2026/05/20) ### 2. Targeting Modulated Vascular Smooth Muscle Cells in Atherosclerosis via FAP-Directed Immunotherapy (Xenium in situ + Visium + Human_CITEseq bundle, GSE315246/GSE314851/GSE314596, score 6, n=17+16+58, Homo sapiens, pdat 2026/02/02) ### 3. Spatially resolved maternal and fetal cell contributions to severe Preeclampsia (GSE319236, score 6, n=152, Homo sapiens, pdat 2026/06/11) ## 📋 Synthesis Three fresh score-7/score-6 high-impact hits spanning bioinformatics/multi-omics (craniosynostosis suture stem cell spatiotemporal atlas), AI drug discovery (FAP-directed atherosclerosis immunotherapy bundle across Xenium/Visium/CITE-seq), and clinical/obstetrics spatial (large n=152 maternal-fetal preeclampsia spatial atlas), drawn from the research-watcher's 2026-06-25 run (watcher ran today on its normal 06:00 KST cadence; hits.jsonl re-archived at 06:01 KST; 103 hits ingested in the latest/ output directory; ~70 unique non-digested accessions after de-duplicating against id:18–id:22): (1) Spatiotemporal single-cell atlas of suture stem cell dynamics in craniosynostosis [scRNA-Seq] (GSE303460, score 7, n=14, pdat 2026/05/20, single-cell + spatial, Mus musculus, clean license, raw files, no risk signals) + Spatiotemporal single-cell atlas of suture stem cell dynamics in craniosynostosis [Visium HD] (GSE303344, score 7, n=3, pdat 2026/05/20, single-cell + spatial, Mus musculus, clean license, raw files, no risk signals, suppfile H5/ZIP) — a freshly indexed score-7 paired scRNA-Seq + Visium HD bundle dissecting suture-stem-cell dynamics across the developmental trajectory of craniosynostosis (the premature fusion of cranial sutures, the most common human craniofacial birth defect); the scRNA-Seq + Visium HD pairing is the gold-standard single-cell + spatial design for developmental-biology atlases and a direct input for Brown Biotech's developmental-biology / skeletal-biology bioinformatics lane; pairs conceptually with the GSE298379 cross-model osteopontin PKD atlas (id:20) on a shared mesenchymal-niche thread. (2) Targeting Modulated Vascular Smooth Muscle Cells in Atherosclerosis via FAP-Directed Immunotherapy [Xenium in situ] (GSE315246, score 6, n=17, pdat 2026/02/02, protein-design / spatial, Homo sapiens, clean license, raw files, no risk signals, suppfile MTX/PARQUET/RDS/TIFF/TSV) + [Visium] (GSE314851, score 6, n=16, pdat 2026/02/02, protein-design / spatial, Homo sapiens, clean license, raw files, no risk signals, suppfile CSV/JPG/JSON/MTX/PNG/RDS/TSV) + [Human_CITEseq] (GSE314596, score 6, n=58, pdat 2026/02/02, protein-design / CITE-seq, Homo sapiens, clean license, raw files, no risk signals, suppfile CSV/RDS) — a score-6 three-modality FAP-directed atherosclerosis immunotherapy bundle (Xenium in situ + Visium + CITE-seq) targeting modulated vascular smooth muscle cells (vSMCs) that drive atherosclerotic plaque instability; direct AI drug discovery input for the Brown Biotech cardiovascular / antibody-therapy lane and clean CMap-repurposing input for next-generation FAP-directed immunotherapies against atherosclerotic cardiovascular disease (CVD, the leading global cause of mortality); the FAP (fibroblast activation protein) angle pairs with the broader FAP-spatial-transcriptomics thread (an extension of the GSE331144 CTHRC1+ fibroblast-fibrosis hit, id:19); the Xenium + Visium + CITE-seq three-modality design is the modern standard for target-validation atlases and complements the GSE308146/GSE308147/GSE308148 three-platform FFPE spatial benchmark bundle (id:22). (3) Spatially resolved maternal and fetal cell contributions to severe Preeclampsia (GSE319236, score 6, n=152, pdat 2026/06/11, spatial, Homo sapiens, clean license, raw files, no risk signals, suppfile CSV/JPG/MTX/TIFF/TSV) — a freshly deposited (pdat = 14 days ago) score-6 large n=152 spatial atlas dissecting the maternal-vs-fetal cellular contributions to severe preeclampsia (the pregnancy-specific hypertensive disorder affecting 2-8% of pregnancies globally and a leading cause of maternal/fetal morbidity and mortality); direct clinical/obstetrics input for Brown Biotech's clinical/translational service and clean reference for the reproductive-medicine brief; pairs with the broader spatial-cohort QC infrastructure thread (GSE277080 standardized-metrics spatial-transcriptomics hit, id:18) on a shared reproducibility / cross-platform-harmonization angle. --- ## 🎯 Highlights ### 1. Spatiotemporal single-cell atlas of suture stem cells in craniosynostosis — scRNA-Seq (GSE303460, score 7, n=14, pdat 2026/05/20, single-cell + spatial, Mus musculus, clean license, raw files, no risk signals) + Visium HD (GSE303344, score 7, n=3, pdat 2026/05/20, single-cell + spatial, Mus musculus, clean license, raw files, no risk signals, suppfile H5/ZIP): freshly indexed score-7 paired scRNA-Seq + Visium HD bundle dissecting suture-stem-cell dynamics across the developmental trajectory of craniosynostosis (the most common human craniofacial birth defect) — gold-standard single-cell + spatial design for developmental-biology atlases and direct input for Brown Biotech's developmental-biology / skeletal-biology bioinformatics lane; pairs with the GSE298379 cross-model osteopontin PKD atlas (id:20) on shared mesenchymal-niche biology ### 2. FAP-directed atherosclerosis immunotherapy three-modality bundle — Xenium in situ (GSE315246, score 6, n=17, pdat 2026/02/02, protein-design/spatial, Homo sapiens, clean license, raw files, no risk signals, suppfile MTX/PARQUET/RDS/TIFF/TSV) + Visium (GSE314851, score 6, n=16, pdat 2026/02/02, protein-design/spatial, Homo sapiens, clean license, raw files, no risk signals, suppfile CSV/JPG/JSON/MTX/PNG/RDS/TSV) + Human_CITEseq (GSE314596, score 6, n=58, pdat 2026/02/02, protein-design/CITE-seq, Homo sapiens, clean license, raw files, no risk signals, suppfile CSV/RDS): score-6 three-modality (Xenium + Visium + CITE-seq) target-validation atlas for FAP-directed atherosclerosis immunotherapy — direct AI drug discovery input for the Brown Biotech cardiovascular / antibody-therapy lane and clean CMap-repurposing input for next-generation FAP-directed CVD immunotherapies (CVD = the leading global cause of mortality); the three-modality Xenium + Visium + CITE-seq design complements the GSE308146/47/48 three-platform FFPE benchmark bundle (id:22) ### 3. Spatially resolved maternal-fetal preeclampsia atlas (GSE319236, score 6, n=152, pdat 2026/06/11, spatial, Homo sapiens, clean license, raw files, no risk signals, suppfile CSV/JPG/MTX/TIFF/TSV): freshly deposited (pdat = 2026-06-11) score-6 large n=152 spatial atlas of maternal-vs-fetal cellular contributions to severe preeclampsia (the pregnancy-specific hypertensive disorder affecting 2-8% of pregnancies globally) — direct clinical/obstetrics input for Brown Biotech's clinical/translational service and clean reference for the reproductive-medicine brief; the spatial single-cell + spatial design (H5/ZIP + MTX/TSV) is the cleanest possible maternal-fetal-interface dissection; pairs with the GSE277080 standardized-metrics spatial-transcriptomics hit (id:18) on shared reproducibility / cross-platform-harmonization ### 4. Combined signal: bioinformatics / multi-omics developmental biology (craniosynostosis suture stem cell atlas) + AI drug discovery cardiovascular immunotherapy (FAP-directed atherosclerosis bundle across Xenium/Visium/CITE-seq) + clinical obstetrics spatial (large n=152 maternal-fetal preeclampsia atlas) — three orthogonal modalities spanning bioinformatics, AI drug discovery, and clinical categories, all clean-license GEO with raw files available; the watcher's 2026-06-25 run completed today on its normal 06:00 KST cadence (latest hits.jsonl archived at 2026-06-25 06:01 KST); ~70 unique non-digested accessions remain in the queue after de-duplicating against id:18–id:22 --- ## 💼 Next Steps - **[Request bioinformatics / craniosynostosis brief](https://brownbio.tech/multiomics#brief)** - **[Request AI drug discovery / FAP-CVD brief](https://brownbio.tech/services/ai-drug-discovery#brief)** - **[Request clinical / preeclampsia brief](https://brownbio.tech/services/biostatx#brief)** - **[View biostatx service](https://brownbio.tech/services/biostatx)** --- ## 📡 Provenance - **Source:** research-watcher (PubMed/GEO scan, 27 query families × Brown Biotech pipelines) - **Pipeline:** [`brown-biotech-daily-tech-digest`](https://github.com/ohbryt/brown-biotech-platform) — 06:00 KST cron - **Generated:** 2026-06-25 06:09 KST - **Repo:** `ohbryt/brown-biotech-platform` --- _Auto-published by `brown_biotech_research_digest_publisher.py` · [brownbio.tech](https://brownbio.tech) · Decision-ready research, daily._
Brown Biotech Research Digest — 2026-06-25
PubMed/GEO scan · research-watcher · 06:00 KST