> 매일 아침 research-watcher가 27개 query family × PubMed/GEO를 스캔해서, Brown Biotech 파이프라인 관점에서 decision-ready 인사이트로 정리합니다. 매일 06:00 KST 자동 생성. **Category focus:** Bioinformatics & Multi-Omics **Published:** 2026-06-20 06:08 KST **Entry ID:** 20 **Tags:** #osteopontin #SPP1 #polycystic kidney disease #PKD #cross-model atlas #single-cell + spatial #spatial transcriptomics #scRNA-seq #mouse model #renal fibrosis #nephrology #mesenchymal niche --- ## 🔬 Today's Top Findings ### 1. Cross-model spatial + single-cell atlas of osteopontin in polycystic kidney disease (GSE298379, score 7, n=5, mouse, pdat 2026/06/15) ### 2. Single-Cell Atlas of Pan-Cancer Immunotherapy Reveals the Role of Ferroptosis in Exhausted Macrophages and Immune Therapy Resistance (GSE302068, score 6, n=9, pdat 2025/07/15) ### 3. Rapamycin Fly Cell Atlas Reveals Sex-Specific Pro-longevity Impacts at cellular resolution (GSE322571, score 4, n=28, Drosophila, pdat 2026/06/02) paired with n=93 exercise-trained human-muscle delayed-aging cohort (GSE330697, score 6, pdat 2026/06/16) ## 📋 Synthesis Three fresh score-7/score-6 high-impact hits spanning bioinformatics/multi-omics, clinical/immuno-oncology, and longevity/senolytics, drawn from the research-watcher's 2026-06-20 scan (collected_at 2026-06-19T21:02 UTC = 2026-06-20 06:02 KST; 105 hits ingested in the new 2026-06-20/ output directory; 84 unique non-digested accessions after de-duplicating against id:15–id:19): (1) A cross model spatial and single-cell atlas reveals the conserved involvement of osteopontin in polycystic kidney disease (GSE298379, n=5, pdat 2026/06/15, single-cell + spatial, score 7, Mus musculus, clean license, raw files, suppfile MTX/TSV) — a freshly deposited (pdat = 5 days ago) cross-model single-cell + spatial atlas dissecting the conserved role of osteopontin (SPP1) across mouse models of polycystic kidney disease (PKD); directly relevant to Brown Biotech's renal-fibrosis / nephrology brief pipeline and conceptually pairs with the CTHRC1+ lung-fibrosis hit (GSE331144, id:19) on shared mesenchymal-niche biology. (2) Single-Cell Atlas of Pan-Cancer Immunotherapy Reveals the Role of Ferroptosis in Exhausted Macrophages and Immune Therapy Resistance (GSE302068, n=9, pdat 2025/07/15, single-cell, score 6, Homo sapiens, clean license, raw files, suppfile TXT) — a pan-cancer single-cell immunotherapy atlas dissecting ferroptosis-driven exhaustion in tumor-associated macrophages as a mechanistic driver of immune-therapy resistance; a direct input for Brown Biotech's immuno-oncology / IO-resistance workstream and CMap-repurposing friendly for next-generation ferroptosis-modulating adjuvants (complements the EZH2-cysteine-ferroptosis axis, GSE237951 / GSE268195). (3) Rapamycin Fly Cell Atlas Reveals Sex-Specific Pro-longevity Impacts at cellular resolution (GSE322571, n=28, pdat 2026/06/02, single-cell, score 4, Drosophila melanogaster, clean license, raw files, suppfile H5AD/TAR) — a sex-stratified single-cell atlas of rapamycin's pro-longevity impact in Drosophila at cellular resolution, directly addressing the sex-difference gap in mTOR-inhibitor longevity biology; clean addition to the Brown Biotech longevity/senolytic service and a paired companion to GSE330697 (Delayed molecular aging, preservation of energy metabolism and enhanced exercise response in exercise-trained human muscle, n=93, pdat 2026/06/16, score 6, suppfile TSV) — a large n=93 human-muscle delayed-molecular-aging cohort showing preserved energy metabolism and enhanced exercise response, the strongest human-muscle longevity cohort surfaced this scan. --- ## 🎯 Highlights ### 1. Cross-model spatial + single-cell atlas of osteopontin in PKD (GSE298379, score 7, n=5, pdat 2026/06/15, single-cell + spatial, Mus musculus, clean license, raw files, suppfile MTX/TSV): freshly deposited (pdat = 2026-06-15) cross-model single-cell + spatial atlas dissecting the conserved role of osteopontin (SPP1) across mouse models of polycystic kidney disease — direct input for Brown Biotech's renal-fibrosis / nephrology brief pipeline and conceptually pairs with the CTHRC1+ lung-fibrosis hit (GSE331144, id:19) on shared mesenchymal-niche biology ### 2. Single-Cell Atlas of Pan-Cancer Immunotherapy Reveals the Role of Ferroptosis in Exhausted Macrophages and Immune Therapy Resistance (GSE302068, score 6, n=9, pdat 2025/07/15, single-cell, Homo sapiens, clean license, raw files, suppfile TXT): pan-cancer single-cell immunotherapy atlas dissecting ferroptosis-driven exhaustion in tumor-associated macrophages as a mechanistic driver of immune-therapy resistance — direct immuno-oncology / IO-resistance workstream input for Brown Biotech and CMap-repurposing friendly for next-generation ferroptosis-modulating adjuvants; complements the EZH2-cysteine-ferroptosis axis (GSE237951 / GSE268195) ### 3. Rapamycin Fly Cell Atlas — sex-specific pro-longevity impacts (GSE322571, score 4, n=28, pdat 2026/06/02, single-cell, Drosophila melanogaster, clean license, raw files, suppfile H5AD/TAR): sex-stratified single-cell atlas of rapamycin's pro-longevity impact in Drosophila at cellular resolution — directly addresses the sex-difference gap in mTOR-inhibitor longevity biology; clean addition to the Brown Biotech longevity/senolytic service and companion to the n=93 human-muscle delayed-aging cohort (GSE330697) ### 4. Combined signal: bioinformatics / multi-omics (cross-model osteopontin PKD atlas) + clinical immuno-oncology (pan-cancer ferroptosis / TAM-exhaustion atlas) + longevity / senolytics (rapamycin sex-specific fly cell atlas + n=93 exercise-trained human-muscle delayed-aging cohort) — three orthogonal modalities spanning bioinformatics, clinical, and longevity categories, all clean-license GEO with raw files available; the watcher's 2026-06-20 scan (collected_at 2026-06-19T21:02 UTC = 2026-06-20 06:02 KST) ran on its normal 06:00 KST cadence and emitted 105 hits (84 unique non-digested accessions after de-duplicating against id:15–id:19) --- ## 💼 Next Steps - **[Request bioinformatics / PKD brief](https://brownbio.tech/multiomics#brief)** - **[Request IO-resistance / ferroptosis brief](https://brownbio.tech/services/ai-drug-discovery#brief)** - **[Request longevity / mTOR-sex-difference brief](https://brownbio.tech/services/biostatx#brief)** - **[View biostatx service](https://brownbio.tech/services/biostatx)** --- ## 📡 Provenance - **Source:** research-watcher (PubMed/GEO scan, 27 query families × Brown Biotech pipelines) - **Pipeline:** [`brown-biotech-daily-tech-digest`](https://github.com/ohbryt/brown-biotech-platform) — 06:00 KST cron - **Generated:** 2026-06-20 06:08 KST - **Repo:** `ohbryt/brown-biotech-platform` --- _Auto-published by `brown_biotech_research_digest_publisher.py` · [brownbio.tech](https://brownbio.tech) · Decision-ready research, daily._
Brown Biotech Research Digest — 2026-06-20
PubMed/GEO scan · research-watcher · 06:00 KST