> 매일 아침 research-watcher가 27개 query family × PubMed/GEO를 스캔해서, Brown Biotech 파이프라인 관점에서 decision-ready 인사이트로 정리합니다. 매일 06:00 KST 자동 생성. **Category focus:** Bioinformatics & Multi-Omics **Published:** 2026-06-19 06:38 KST **Entry ID:** 19 **Tags:** #vtRNA #vault RNA #vault particle #non-coding RNA #HEK293T #knockout #perturbation #RNA-seq #CMap repurposing #AI drug discovery #chronic antibody-mediated rejection #cABMR --- ## 🔬 Today's Top Findings ### 1. RNA sequencing of vtRNA-knockout HEK293T cell lines (n=36, score 9, perturbation) ### 2. single-cell + spatial immune atlas of chronic antibody-mediated rejection reveals a CXCL12-CXCR4 fibroblast-immune niche (score 9, pdat 2026/06/10) ### 3. transcriptional and spatial profiling of human lung fibroblasts highlights CTHRC1+ cells as fibrogenic signaling hubs (n=9, score 9, pdat 2026/05/29) ## 📋 Synthesis Three fresh score-9 high-impact hits spanning AI drug discovery (vtRNA perturbation), clinical/transplantation bioinformatics (chronic antibody-mediated rejection single-cell + spatial atlas), and pulmonary-fibrosis/longevity (CTHRC1+ lung-fibroblast fibrogenic hubs), drawn from the research-watcher's 2026-06-19 scan (collected_at 2026-06-18T21:02:39 UTC = 2026-06-19 06:02 KST; 103 hits ingested in the new 2026-06-19/ output directory; 76 unique non-digested accessions after de-duplicating against id:14–id:18): (1) RNA sequencing of vtRNA-knockout HEK293T cell lines (GSE335700, n=36, pdat 2026/06/17, mixed modality — RNA-seq + Other, score 9, clean license, raw files, perturbation signal, no risk signals, suppfile TXT) — a freshly deposited (pdat = 2 days ago) score-9 KO transcriptomic profiling of vault RNA (vtRNA) in HEK293T, the cleanest possible perturbation design for a still-under-explored non-coding-RNA class (vtRNAs are the RNA component of the vault particle and have rising interest in drug-efflux regulation, apoptosis, and innate immunity); direct AI drug discovery input for the Brown Biotech vtRNA / vault-particle drug-target lane and CMap-repurposing friendly for next-generation non-coding-RNA therapeutics. (2) A single-cell and spatial immune atlas of chronic antibody-mediated rejection reveals autoimmune-shared immune states and a CXCL12-CXCR4 fibroblast-immune niche (GSE328870, pdat 2026/06/10, single-cell + spatial, score 9, clean license, raw files, no risk signals, suppfile RDS/TXT/XLSX) — a score-9 transplantation-immunology atlas dissecting chronic antibody-mediated rejection (cABMR, the leading cause of long-term solid-organ allograft loss) and surfacing a CXCL12-CXCR4 fibroblast-immune niche that mirrors autoimmune-shared immune states; direct input for Brown Biotech's clinical/translational service and a clean reference for the transplant-immunology brief, conceptually paired with the GSE331144 CTHRC1+ fibroblast-fibrosis hit (shared fibroblast-niche angle). (3) Transcriptional and spatial profiling of fibroblasts from human lungs highlights CTHRC1+ cells as fibrogenic signaling hubs in fibrosis (GSE331144, n=9, pdat 2026/05/29, single-cell + spatial, score 9, clean license, raw files, no risk signals, suppfile TXT) — a score-9 single-cell + spatial dissection of CTHRC1+ fibroblasts as fibrogenic signaling hubs in human lung fibrosis, a direct input for the Brown Biotech anti-fibrotic / pulmonary-fibrosis pipeline and a clean CMap-repurposing input for next-generation CTHRC1 / TGF-β-axis inhibitors; complements the CTHRC1+ lung-fibrosis biology already touched in id:12 and the FALD spatial transcriptomics of human fibrotic livers (GSE306111, id:14). --- ## 🎯 Highlights ### 1. vtRNA-knockout HEK293T RNA-seq (GSE335700, score 9, n=36, pdat 2026/06/17, mixed, clean license, raw files, perturbation signal, suppfile TXT): freshly deposited (pdat = 2026-06-17) score-9 KO transcriptomic profiling of vault RNA (vtRNA) in HEK293T — clean perturbation design for an under-explored non-coding-RNA class with rising interest in drug-efflux regulation, apoptosis, and innate immunity; direct AI drug discovery input for the Brown Biotech vtRNA / vault-particle drug-target lane and CMap-repurposing friendly for next-generation non-coding-RNA therapeutics ### 2. Single-cell + spatial immune atlas of chronic antibody-mediated rejection (GSE328870, score 9, pdat 2026/06/10, single-cell + spatial, clean license, raw files, suppfile RDS/TXT/XLSX): score-9 transplantation-immunology atlas dissecting cABMR (the leading cause of long-term solid-organ allograft loss) and surfacing a CXCL12-CXCR4 fibroblast-immune niche that mirrors autoimmune-shared immune states — direct input for Brown Biotech's clinical/translational service and clean reference for the transplant-immunology brief; conceptually paired with the GSE331144 CTHRC1+ fibroblast-fibrosis hit (shared fibroblast-niche angle) ### 3. CTHRC1+ fibroblasts as fibrogenic signaling hubs in human lung fibrosis (GSE331144, score 9, n=9, pdat 2026/05/29, single-cell + spatial, clean license, raw files, suppfile TXT): score-9 single-cell + spatial dissection of CTHRC1+ fibroblasts as fibrogenic signaling hubs in human lung fibrosis — direct input for the Brown Biotech anti-fibrotic / pulmonary-fibrosis pipeline and clean CMap-repurposing input for next-generation CTHRC1 / TGF-β-axis inhibitors; complements the CTHRC1+ lung-fibrosis biology touched in id:12 and the FALD spatial transcriptomics of human fibrotic livers (GSE306111, id:14) ### 4. Combined signal: AI drug discovery non-coding-RNA perturbation (vtRNA) + clinical/transplantation bioinformatics single-cell + spatial atlas (cABMR CXCL12-CXCR4 niche) + pulmonary-fibrosis/longevity single-cell + spatial (CTHRC1+ fibroblast hubs) — three orthogonal modalities spanning AI drug discovery, clinical, and longevity categories, all clean-license GEO with raw files available; the watcher's 2026-06-19 scan (collected_at 2026-06-18T21:02:39 UTC = 2026-06-19 06:02 KST) ran on its normal 06:00 KST cadence and emitted 103 hits (76 unique non-digested accessions after de-duplicating against id:14–id:18) --- ## 💼 Next Steps - **[Request AI drug discovery / vtRNA brief](https://brownbio.tech/services/ai-drug-discovery#brief)** - **[Request transplant immunology / cABMR brief](https://brownbio.tech/services/biostatx#brief)** - **[Request anti-fibrotic / lung fibrosis brief](https://brownbio.tech/services/biostatx#brief)** - **[View biostatx service](https://brownbio.tech/services/biostatx)** --- ## 📡 Provenance - **Source:** research-watcher (PubMed/GEO scan, 27 query families × Brown Biotech pipelines) - **Pipeline:** [`brown-biotech-daily-tech-digest`](https://github.com/ohbryt/brown-biotech-platform) — 06:00 KST cron - **Generated:** 2026-06-19 06:38 KST - **Repo:** `ohbryt/brown-biotech-platform` --- _Auto-published by `brown_biotech_research_digest_publisher.py` · [brownbio.tech](https://brownbio.tech) · Decision-ready research, daily._
Brown Biotech Research Digest — 2026-06-19
PubMed/GEO scan · research-watcher · 06:00 KST